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#hematology

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"We analyzed cancer-related gene sequences in the blood of patients with solid tumors to better understand the relationship between clonal hematopoiesis and hematologic malignancy in this population. We found that mutations in JAK2 were strongly associated with subsequent MPN, RUNX1 mutations with subsequent therapy-related myeloid neoplasms (MDS/AML), and XPO1 mutations with subsequent chronic lymphocytic leukemia."
#Hematology

ashpublications.org/bloodadvan

American Society of HematologyHigh-risk and silent clonal hematopoietic genotypes in patients with nonhematologic cancerHigh-risk CH mutations in JAK2, RUNX1, and XPO1 anticipate hematologic malignancy in patients with cancer.Functionally neutral silent CH variants are significan

Magrolimab is an anti-CD47

'Gilead Sciences, Inc. today announced it has discontinued the Phase 3 ENHANCE-3 study of magrolimab in AML and that the (FDA) placed all magrolimab studies in myelodysplastic syndromes and AML, including related expanded access programs, on full clinical hold'
#Leukemia #ClinicalTrial #CD47 #Hematology

gilead.com/news-and-press/comp

www.gilead.comGilead Statement on Discontinuation of Phase 3 ENHANCE-3 Study in AML