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CellBioNews<a href="https://scientificnetwork.de/tags/Mitochondria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mitochondria</a> are flinging their <a href="https://scientificnetwork.de/tags/DNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNA</a> into our <a href="https://scientificnetwork.de/tags/brain_cells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain_cells</a>, study shows.<a href="https://scientificnetwork.de/tags/mtDNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mtDNA</a> <a href="https://scientificnetwork.de/tags/genome_transfer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#genome_transfer</a> <a href="https://scientificnetwork.de/tags/insertions" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#insertions</a> <a href="https://scientificnetwork.de/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a><a href="https://phys.org/news/2024-08-mitochondria-dna-brain-cells.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://phys.org/news/2024-08-mitochondria-dna-brain-cells.html</a>

Matt WillemsenCancer Cells Give Orders <a href="https://www.the-scientist.com/cancer-cells-give-orders-71792" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.the-scientist.com/cancer-cells-give-orders-71792</a> <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> <a href="https://mastodon.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> <a href="https://mastodon.social/tags/progression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#progression</a> <a href="https://mastodon.social/tags/CAF" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CAF</a> <a href="https://mastodon.social/tags/EndothelialCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EndothelialCells</a>

Matt WillemsenRegular Erections May Be Vital For Erectile Function <a href="https://www.sciencealert.com/regular-erections-may-be-vital-for-erectile-function" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencealert.com/regular-erections-may-be-vital-for-erectile-function</a> <a href="https://mastodon.social/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#health</a> <a href="https://mastodon.social/tags/male" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#male</a> <a href="https://mastodon.social/tags/erections" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#erections</a> <a href="https://mastodon.social/tags/ErectileFunction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ErectileFunction</a> <a href="https://mastodon.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> <a href="https://mastodon.social/tags/increased" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#increased</a> <a href="https://mastodon.social/tags/frequency" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#frequency</a>

Matt WillemsenViagra alternatives? Study of mouse erections hints at new ways to treat erectile dysfunction <a href="https://www.livescience.com/health/sex/viagra-alternatives-study-of-mouse-erections-hints-at-new-ways-to-treat-erectile-dysfunction" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.livescience.com/health/sex/viagra-alternatives-study-of-mouse-erections-hints-at-new-ways-to-treat-erectile-dysfunction</a> <a href="https://mastodon.social/tags/Viagra" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Viagra</a> <a href="https://mastodon.social/tags/alternatives" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alternatives</a> <a href="https://mastodon.social/tags/mice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mice</a> <a href="https://mastodon.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> <a href="https://mastodon.social/tags/NotchSignalingPathway" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NotchSignalingPathway</a>

Julien DelpierreNew <a href="https://biologists.social/tags/mechanobiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mechanobiology</a> paper on <a href="https://biologists.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> <a href="https://biologists.social/tags/microenvironment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microenvironment</a>. The authors show that cancer-associated <a href="https://biologists.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> (CAFs) compress tumors with actomyosin supracellular contractility supported by <a href="https://biologists.social/tags/fibronectin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibronectin</a> deposition. This induces <a href="https://biologists.social/tags/YAP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#YAP</a> nuclear exit in cancer cells, limits cancer growth, and induces tumor reorganization.<a href="https://www.nature.com/articles/s41467-023-42382-4" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41467-023-42382-4</a>

Scientific FrontlineResearchers have found that <a href="https://mastodon.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> – scar-forming <a href="https://mastodon.social/tags/cells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cells</a> that reside in the <a href="https://mastodon.social/tags/scar" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#scar</a> tissue of an injured heart -- directly play a role in promoting a disturbance of the <a href="https://mastodon.social/tags/heart" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#heart</a> rhythm, otherwise known as an <a href="https://mastodon.social/tags/arrhythmia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#arrhythmia</a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2023/09/med09282302.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2023/09/med09282302.html</a>

katch wreck`Tail blastema, but not limb, <a href="https://mastodon.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> express sulf1 and form <a href="https://mastodon.social/tags/cartilage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cartilage</a> under Hedgehog signaling regulation. Depletion of phagocytes inhibits blastema formation, but treatment with pericytic phagocyte-conditioned media rescues blastema chondrogenesis and cartilage formation in amputated limbs... These properties..indicate potential actionable targets for inducing <a href="https://mastodon.social/tags/regeneration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#regeneration</a> in other species, including humans` <a href="https://www.nature.com/articles/s41467-023-40206-z" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41467-023-40206-z</a>

The EMBO JournalHigh-resolution <a href="https://sciencemastodon.com/tags/transcriptomic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcriptomic</a> and <a href="https://sciencemastodon.com/tags/epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetic</a> profiling identifies novel regulators of chronic obstructive pulmonary disease <a href="https://sciencemastodon.com/tags/COPD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COPD</a> Multi-omics resource of primary human lung <a href="https://sciencemastodon.com/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> across COPD stages by Renata Jurkowska and coworkers at Cardiff University<a href="https://www.embopress.org/doi/10.15252/embj.2022111272" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/10.15252/embj.2022111272</a>

PLOS BiologyFibroblasts were traditionally seen as structural cells, but technological advances have revealed important roles in immune function. @arthritisbham @ColesBuckleyLab &co from @KirOxford look at why <a href="https://fediscience.org/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> matters for health and disease. <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3JI5Cwp" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3JI5Cwp</a>

Søren Grubb<a href="https://mas.to/tags/Collagen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Collagen</a> is mainly synthesized by <a href="https://mas.to/tags/Fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Fibroblasts</a>, strengthening <a href="https://mas.to/tags/Arteriole" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Arteriole</a> and <a href="https://mas.to/tags/Capillary" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Capillary</a> vessel wall. <a href="https://mas.to/tags/Ultrastructure" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Ultrastructure</a> shows <a href="https://mas.to/tags/fibripositors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibripositors</a> where <a href="https://mas.to/tags/collagenfibril" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#collagenfibril</a> <a href="https://mas.to/tags/tripelhelixes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tripelhelixes</a> are made and <a href="https://mas.to/tags/fibrils" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibrils</a> that reach across the <a href="https://mas.to/tags/PerivascularSpace" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PerivascularSpace</a> (8/15)

haven4booksRNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms <a href="https://www.mdpi.com/2073-4409/11/24/4040" rel="nofollow noopener noreferrer" target="_blank">https://www.mdpi.com/2073-4409/11/24/4040</a>"Over the last years, our group contributed to this current view by demonstrating that dermal fibroblasts from hEDS and HSD patients share a common cellular phenotype [19,20], which is not present in other EDS types and HCTDs"<a href="https://weirder.earth/tags/EDS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EDS</a> <a href="https://weirder.earth/tags/hEDS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hEDS</a> <a href="https://weirder.earth/tags/HSD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HSD</a> <a href="https://weirder.earth/tags/hypermobility" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hypermobility</a> <a href="https://weirder.earth/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> <a href="https://weirder.earth/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> <a href="https://weirder.earth/tags/MedMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MedMastodon</a> <a href="https://weirder.earth/tags/NEISvoid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NEISvoid</a> <a href="https://weirder.earth/tags/ConnectiveTissue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ConnectiveTissue</a>

Alice DentonGreetings mastadoners (is that a word here?) I have joined the great migration. I’m here for <a href="https://mastodon.au/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> <a href="https://mastodon.au/tags/vaccines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vaccines</a> <a href="https://mastodon.au/tags/germinalcentres" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#germinalcentres</a> <a href="https://mastodon.au/tags/ageing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ageing</a> and tbh <a href="https://mastodon.au/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> in general. 👩‍🔬🧪🧫 Also cats please 🐈 🐈‍⬛

haven4books<a href="https://weirder.earth/tags/hEDS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hEDS</a> up <a href="https://weirder.earth/tags/NEISvoid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NEISvoid</a>You can listen or read the <a href="https://weirder.earth/tags/transcript" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcript</a> of this episode below, which includes a take-down of the <a href="https://weirder.earth/tags/BeightonScore" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BeightonScore</a> used for diagnosing (and denying diagnosis of) <a href="https://weirder.earth/tags/EhlersDanlosSyndrome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EhlersDanlosSyndrome</a>, a discussion of both the 2017 criteria and the new revisions under discussion, as well as <a href="https://weirder.earth/tags/CurrentResearch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CurrentResearch</a> into <a href="https://weirder.earth/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a>.The guest is Sabeeha Malek, a PhD student doing biomedical <a href="https://weirder.earth/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> into <a href="https://weirder.earth/tags/EDS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EDS</a> who also has EDS.<a href="https://weirder.earth/tags/PatientLed" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PatientLed</a> ***What happens when diagnostic criteria aren’t fit for purpose | The Rest Room <a href="https://weirder.earth/tags/podcast" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#podcast</a>🔗 <a href="http://natashalipman.com/what-happens-when-diagnostic-criteria-arent-fit-for-purpose/" rel="nofollow noopener noreferrer" target="_blank">http://natashalipman.com/what-happens-when-diagnostic-criteria-arent-fit-for-purpose/</a>"EDS isn’t necesarily a Hypermobility disorder, it’s a connective tissue disorder. And Hypermobility is just one manifestation of the connective tissue disorder."<a href="https://a.gup.pe/u/chronicillness" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@chronicillness</a>

Aled ParryI'm really quite excited to see this <a href="https://genomic.social/tags/published" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#published</a>.The Knowles lab in <a href="https://genomic.social/tags/Cambridge" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cambridge</a> (led by Hongjia Zhu and Lianne Roode) developed a cool method of producing <a href="https://genomic.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> spheroids within microgels.Co-cultures of cancer cells with <a href="https://genomic.social/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a> +/- <a href="https://genomic.social/tags/Notch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Notch</a> signalling (one of my first loves when I was in the Narita Lab!) grow at different rates within these microgels - and we saw the same effect in vivo! A really cool tool, congrats to all involved :rna: :agar_plate: <a href="https://doi.org/10.1002/anbr.202200138" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1002/anbr.202200138</a>

Ute JungwirthAn introduction - I am an Assistant Professor @ University of Bath (UK) with a <a href="https://mstdn.science/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#research</a> team focusing on how tumour cells interact with its surrounding non-cancerous cells (we love <a href="https://mstdn.science/tags/fibroblasts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#fibroblasts</a>, and sometimes we hate them). These interactions can impact tumour progression, <a href="https://mstdn.science/tags/metastasis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#metastasis</a> & therapy response. We also test novel anticancer compounds from our medicinal/biological chemistry colleagues. Furthermore, I teach the next generation in <a href="https://mstdn.science/tags/pharmacology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pharmacology</a>, <a href="https://mstdn.science/tags/toxicology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#toxicology</a>, <a href="https://mstdn.science/tags/cancerresearch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancerresearch</a>.

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