In the most recent episode of the Epigenetics Podcast, we talked with Sarah Teichmann from the University of Cambridge about the Human Cell Atlas. #podcast #epigenetics #chromatin
Listen here: https://www.activemotif.com/podcasts-sarah-teichmann
In the most recent episode of the Epigenetics Podcast, we talked with Sarah Teichmann from the University of Cambridge about the Human Cell Atlas. #podcast #epigenetics #chromatin
Listen here: https://www.activemotif.com/podcasts-sarah-teichmann
https://www.europesays.com/uk/263330/ Top AI medical scientists Roland Eils and Irina Lehmann leave Germany for China #AI #AIInMedicine #ArtificialIntelligence #Berlin #BIH #CharitéUniversityOfMedicine #China #Chinese #ComputationalBiologist #Covid19Pandemic #DeepLearning #Eils #Epigenetics #EU #Europe #FudanUniversity #german #Germany #IntelligentMedicine #IrinaLehmann #LargeLanguageModel #LLM #MedicalAI #MolecularEpidemiology #Research #Science #Shanghai #SmartMedicine #UniversityOfHeidelberg
“When IDO1 is blocked, however, macrophages regain their ability to absorb cholesterol.This suggests that reducing IDO1 activity could offer a new way to help prevent heart disease by keeping cholesterol levels in check.” #DNA #isogg #epigenetics #cholesterol #geneadons
In this episode of the Epigenetics Podcast, we talked with Sarah Teichmann from the University of Cambridge about the Human Cell Atlas. #podcast #epigenetics #chromatin
Listen here: https://www.activemotif.com/podcasts-sarah-teichmann
"In humans, early-life conditions similarly shape development. A child raised in an unsafe setting may develop heightened vigilance or stress sensitivity – traits that help in danger but can persist as anxiety or chronic stress in times of safety. This is known as environmental mismatch.
Across generations, plasticity becomes more complicated.
(. . .)
Epigenetics often reflect environmental exposures – such as stress, trauma, nutrition or caregiving. But they’re not necessarily permanent 'scars'. Many are dynamic and can shift with changing environments – especially early in life.
Studies show that epigenetic patterns linked to early childhood adversity vary depending on later environments such as family stability and social support. This suggests the biological imprint of early stress is shaped by what happens next.
It’s tempting to treat epigenetics as the key to explaining inherited trauma – but that’s too narrow. Trauma can influence the next generation through altered hormones, immune function or in utero conditions – all of which shape brain development and stress reactivity.
Genetic variation also plays a major role. It doesn’t encode trauma itself, but it shapes traits such as sensitivity to threat or emotional regulation. These traits aren’t chosen – they arise from a web of biological and social influences beyond our control.
But how they unfold, and whether they’re amplified or softened, depends on the systems that surround us.
Connection to culture plays an important role too.
In Aotearoa New Zealand, Māori-led initiatives that centre land, language and whakapapa (ancestral lineage) have shown promise in restoring wellbeing after generations of colonisation-related trauma.
For Holocaust survivors and descendants, connection to cultural identity through ritual and shared narrative can reduce the psychological burden of transmitted trauma.
But not all trauma is collective or institutional. Interventions such as trauma-informed parenting and early relational therapies have been shown to improve outcomes in the next generation.
These psychological supports affect biology. Feeling safe in our relationships, having stable routines and a sense of meaning can reduce stress hormones, modulate immune function, and buffer against long-term disease risk.
In this way, culture, caregiving and connection are all biological interventions. When they soften the effects of earlier stress, they may help interrupt its transmission."
Las técnicas de reproducción asistida podrían afectar el perfil epigenético sanguíneo materno, con consecuencias obstétricas desfavorables:
https://www.rbmojournal.com/article/S1472-6483(25)00337-2/fulltext
#bianorbiotech #epigenetics #obstetrics #ART #miRNA
“These findings identify a light-responsive cell-intrinsic timer that controls time-of-day variations in antibacterial activity.” #isogg #DNA #epigenetics #circadian #geneadons
This shift was mirrored in chromatin accessibility.
scATAC-seq revealed stage-specific enhancer activation, with late-born cells opening distinct regulatory elements — especially in distal regions. A dynamic change in the regulatory landscape.
#NewsMayerlab #Chromatin #Epigenetics #scATACseq
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Tabaco y efectos en la fertilidad masculina. Esta revisión analiza el efecto en la descendencia a través de la alteración de marcas epigenéticas en el espermatozoide.
https://www.spandidos-publications.com/10.3892/br.2025.2024
#bianorbiotech #smoking #MaleFertility #epigenetics #offspring
“Addressing sleep disturbance and deficiency may have a positive impact on risk for incident dementia and all-cause mortality among older adults.”
#isogg #epigenetics #geneadons #dementia #alzheimers https://pubmed.ncbi.nlm.nih.gov/33570509/
Interest in the idea of transgenerational trauma has recently surged. For example, earlier this year, National Geographic magazine asked whether genes carry past family trauma.
Hello
@MarkHoltom
“”We’ve got ours, pull up the gangplank #gangplankmentality
On a related note - -
@ MrSlanderer
{1 month ago:
Fun fact: Wild pigs that are introduced to a domesticated herd become tame within a couple weeks, whereas domesticated pigs that escape and join feral herds, become feral within a couple weeks, including developing oversized incisors
¿\https://youtube.com/watch?v=41PVbvsx6ps #BeyondFraming
#PlanetBee
http://www.oocities.org/etearthmission/BSTI.htm #rise
“This innovative strategy could potentially revolutionize our ability to address genetic hearing impairments, offering hope for more effective and durable treatments for individuals across a wider age range and at various stages of hearing loss progression.” #isogg #DNA #epigenetics #hearingloss #geneadons
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1511938/full
Job - Alert
Doctoral Researcher in Functional Cancer Biology (m/f/d)
Deadline: 2025-07-26
Location: Germany, Frankfurt, Hessen
Apply: https://www.academiceurope.com/ads/doctoral-researcher-in-functional-cancer-biology-m-f-d/
Experiments with cultured cells equivalent to human epidermis find that vitamin C promotes the proliferation of skin cells, specifically keratin-containing cells, leading to increases in skin thickness and strength. The mechanism is evidently demethylation of DNA, reactivating genes that control cell proliferation.
Summary: https://www.eurekalert.org/news-releases/1088729
Original paper: https://www.jidonline.org/article/S0022-202X(25)00416-6/fulltext
New to epigenetics? University College London has produced Epigenetics for the Lay Person. #DNA #isogg #epigenetics #geneadons
https://www.ucl.ac.uk/population-health-sciences/womens-health/research/epigenetics-lay-version
In the most recent episode, Professor Asim Surani, shares how his extensive research has significantly advanced the understanding of how the mammalian germline is specified, the mechanisms governing epigenetic reprogramming, and the critical conditions that maintain genomic integrity during early development. #podcast #epigenetics #chromatin
Listen here: https://activemotif.com/podcasts-azim-surani
In this episode, Professor Asim Surani, shares how his extensive research has significantly advanced the understanding of how the mammalian germline is specified, the mechanisms governing epigenetic reprogramming, and the critical conditions that maintain genomic integrity during early development. #podcast #epigenetics #chromatin
Listen here: https://activemotif.com/podcasts-azim-surani
“The authors explained that carnosic acid works by activating enzymes in the body's "natural defense system." They created a stable form known as diAcCA, which once consumed, converts to carnosic acid in the gut and is then absorbed into the bloodstream.”#isogg #dna #epigenetics #alzheimers #rosemary
https://www.foodandwine.com/rosemary-carnosic-acid-alzheimers-treatment-11754104
Korfmann et al. compare methylome and genome variation in two plant specoes, showing that CG methylation captures recent demographic events missed by SNPs, and present a new deep learning method using methylation to infer demographic histories.
doi.org/10.1093/gbe/evaf101