Med-Mastodon

AuscandocB.C. research: New blood test could 'transform' cancer treatment | CTV News <a href="https://bc.ctvnews.ca/new-blood-test-could-transform-cancer-treatment-b-c-research-1.6006877" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://bc.ctvnews.ca/new-blood-test-could-transform-cancer-treatment-b-c-research-1.6006877</a> <a href="https://bc.ctvnews.ca/mobile/new-blood-test-could-transform-cancer-treatment-b-c-research-1.6006877?cache=yesclipId10406200text/html;charset=utf-80404/7.263352" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://bc.ctvnews.ca/mobile/new-blood-test-could-transform-cancer-treatment-b-c-research-1.6006877?cache=yesclipId10406200text/html;charset=utf-80404/7.263352</a> “researchers at <a href="https://med-mastodon.com/tags/BCCancer" class="mention hashtag" rel="tag">#BCCancer</a> and the Vancouver <a href="https://med-mastodon.com/tags/Prostate" class="mention hashtag" rel="tag">#Prostate</a> Centre said they've developed a new blood test that provides "unprecedented" insight into a patient's cancer make-up."analyzes the DNA that <a href="https://med-mastodon.com/tags/metastatic" class="mention hashtag" rel="tag">#metastatic</a> <a href="https://med-mastodon.com/tags/cancers" class="mention hashtag" rel="tag">#cancers</a> shed into the bloodstream, known as circulating tumour DNA or <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a>,"helps to reveal characteristics that are unique to each patient's cancer, “

Lorenzo GerratanaMoving from the simplistic definition of <a href="https://med-mastodon.com/tags/ESR1" class="mention hashtag" rel="tag">#ESR1</a> and <a href="https://med-mastodon.com/tags/PIK3CA" class="mention hashtag" rel="tag">#PIK3CA</a> mutated metastatic <a href="https://med-mastodon.com/tags/BreastCancer" class="mention hashtag" rel="tag">#BreastCancer</a> to a more granular resolution of single codon variants thanks to <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> and <a href="https://med-mastodon.com/tags/LiquidBiopsy" class="mention hashtag" rel="tag">#LiquidBiopsy</a> for a more precise biological and clinical profiling of <a href="https://med-mastodon.com/tags/MBC" class="mention hashtag" rel="tag">#MBC</a> <a href="https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-023-01718-0" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-023-01718-0</a>

Arjan BoltjesA great read on <a href="https://mastodon.social/tags/DrugResistance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DrugResistance</a> in <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a>, in Nature, by Vasan, Baselga, and Hyman. Sure, 2019 is four years ago, so there will be updates, e.g. on mapping <a href="https://mastodon.social/tags/CancerDependency" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CancerDependency</a> or the role of <a href="https://mastodon.social/tags/ctDNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ctDNA</a> in early detection or monitoring. But the framework for understanding drug resistance is here.<a href="https://www.nature.com/articles/s41586-019-1730-1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41586-019-1730-1</a>Although it doesn't say it, I think it may be <a href="https://mastodon.social/tags/OpenAccess" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#OpenAccess</a> since I'm not logged in to my institution right now but can reach full text anyway.<a href="https://mastodon.social/tags/tumour" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tumour</a> <a href="https://mastodon.social/tags/tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tumor</a>

Johnathan Ebben MD, PhDA huge thank you to @shafiarahman_ & @RischZack for presenting us with the latest data in <a href="https://med-mastodon.com/tags/EGFR" class="mention hashtag" rel="tag">#EGFR</a> targeting in <a href="https://med-mastodon.com/tags/metastatic" class="mention hashtag" rel="tag">#metastatic</a> <a href="https://med-mastodon.com/tags/ColorectalCancer" class="mention hashtag" rel="tag">#ColorectalCancer</a>. Excited to see how 🩸🧬<a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> can help us design rational strategies to better use EGFR therapies particularly with re-challenge. --- RT <a href="https://med-mastodon.com/@JohnEbbenMDPhD" class="u-url mention">@JohnEbbenMDPhD</a> @TumorBoardTues @shafiarahman_ @RischZack <a href="https://med-mastodon.com/@MPishvaian" class="u-url mention">@MPishvaian</a> @ColonCancerCoal @colontown @coloncancermike @GlobalCRC 3/6 <a href="https://med-mastodon.com/tags/TumorBoardTuesday" class="mention hashtag" rel="tag">#TumorBoardTuesday</a> 🎥 TBT in a… <a href="https://twitter.com/JohnEbbenMDPhD/status/1639072110139125761" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/JohnEbbenMDPhD/status/1639072110139125761</a>

Johnathan Ebben MD, PhDA huge thank you to the one and only @DrSteveMartin & @DAielloMD for bringing us the <a href="https://med-mastodon.com/tags/MarchMadness" class="mention hashtag" rel="tag">#MarchMadness</a> of <a href="https://med-mastodon.com/tags/NSCLC" class="mention hashtag" rel="tag">#NSCLC</a> and exploring how <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> will change practice! I'm looking forward to that baklava! --- RT <a href="https://med-mastodon.com/@JohnEbbenMDPhD" class="u-url mention">@JohnEbbenMDPhD</a> @TumorBoardTues @DrSteveMartin @DAielloMD <a href="https://med-mastodon.com/@MPishvaian" class="u-url mention">@MPishvaian</a> <a href="https://med-mastodon.com/@NarjustFlorezMD" class="u-url mention">@NarjustFlorezMD</a> @EGFRResisters @lcrf_org <a href="https://med-mastodon.com/@ADesaiMD" class="u-url mention">@ADesaiMD</a> @GDutcherMD 3/5 <a href="https://med-mastodon.com/tags/TumorBoardTuesday" class="mention hashtag" rel="tag">#TumorBoardTuesday</a> Thurs Case🎀🎥 TBT in a video ctDNA + tissue-based NGS= highest sensitivity (do… <a href="https://twitter.com/JohnEbbenMDPhD/status/1634012967149920257" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/JohnEbbenMDPhD/status/1634012967149920257</a>

TumorBoardTuesday<a href="https://mstdn.science/tags/TumorBoardTuesday" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorBoardTuesday</a>🧬@DrSteveMartin @DAielloMD brought a March Madness worthy set of cases that illustrate how <a href="https://mstdn.science/tags/ctDNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ctDNA</a> is being used in <a href="https://mstdn.science/tags/NSCLC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NSCLC</a>. ➡️Here’s the Case 🎀 👉🆓<a href="https://mstdn.science/tags/CME" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CME</a> credit by answering 2 quick ❓ ALL CME 🔗: <a href="http://integrityce.com/tbt" rel="nofollow noopener noreferrer" target="_blank">http://integrityce.com/tbt</a> CME eval🔗: <a href="http://integrityce.com/tbteval" rel="nofollow noopener noreferrer" target="_blank">http://integrityce.com/tbteval</a>

Johnathan Ebben MD, PhDIt's TIME! Follow the thread below as <a href="https://med-mastodon.com/tags/TumorBoardTuesday" class="mention hashtag" rel="tag">#TumorBoardTuesday</a>, led by @DrSteveMartin & @DAielloMD discuss real 🌎 examples of <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> use in <a href="https://med-mastodon.com/tags/NSCLC" class="mention hashtag" rel="tag">#NSCLC</a>. Can't wait to learn 📚 from these cases! --- RT @DAielloMD 1/26 <a href="https://med-mastodon.com/tags/TumorBoardTuesday" class="mention hashtag" rel="tag">#TumorBoardTuesday</a> <a href="https://med-mastodon.com/tags/LungCancer" class="mention hashtag" rel="tag">#LungCancer</a> <a href="https://med-mastodon.com/tags/OncTwitter" class="mention hashtag" rel="tag">#OncTwitter</a> @DrSteveMartin ⛹🏻‍♀️Case 1⛹️‍♂️ 80 yo 👵🏼 never 🚬 🩻 Imaging shows R lung mass 🦴 New hip pain found to have R femoral lytic lesion ⚒️Undergoes ORIF R femur 🔬R femur path: metastatic squamous cel… <a href="https://twitter.com/DAielloMD/status/1633271395550412800" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/DAielloMD/status/1633271395550412800</a>

Lorenzo GerratanaWhat is the role of palbociclib and <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> in patients with HER2-positive <a href="https://med-mastodon.com/tags/BreastCancer" class="mention hashtag" rel="tag">#BreastCancer</a> with active brain metastases? Results from a phase II single-arm study. <a href="https://med-mastodon.com/tags/PrecisionMedicine" class="mention hashtag" rel="tag">#PrecisionMedicine</a> <a href="https://med-mastodon.com/tags/bcsm" class="mention hashtag" rel="tag">#bcsm</a> <a href="https://med-mastodon.com/tags/liquidbiopsy" class="mention hashtag" rel="tag">#liquidbiopsy</a><a href="https://www.clinical-breast-cancer.com/article/S1526-8209(22)00283-X/fulltext" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.clinical-breast-cancer.com/article/S1526-8209(22)00283-X/fulltext</a>

Lorenzo Gerratana<a href="https://med-mastodon.com/tags/ESR1" class="mention hashtag" rel="tag">#ESR1</a> mutations in the docking site of Selective Estrogen Receptor Degraders and Modulators <a href="https://med-mastodon.com/tags/SERD" class="mention hashtag" rel="tag">#SERD</a> differentially impact on drug affinity across agents. Integrating <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> and <a href="https://med-mastodon.com/tags/pharmacodynamics" class="mention hashtag" rel="tag">#pharmacodynamics</a>. <a href="https://med-mastodon.com/tags/PrecisionMedicine" class="mention hashtag" rel="tag">#PrecisionMedicine</a> <a href="https://med-mastodon.com/tags/BreastCancer" class="mention hashtag" rel="tag">#BreastCancer</a>

Manju George MVSc PhDCRC Caregiver perspective: When you are in a country where <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> tests aren’t available, what can you do as a patient/caregiver? Hear about this resourceful caregiver's experience..<a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> @OncoAlert@twitter.com <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

Manju George MVSc PhDQ4. How is serial <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> testing useful in Stage IV MSI-H CRC?<a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> @OncoAlert@twitter.com <a href="https://med-mastodon.com/tags/Colorectalcancer" class="mention hashtag" rel="tag">#Colorectalcancer</a>

Manju George MVSc PhDQ3. Let’s talk about clinical trials to assess utility of <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> testing in stage IV <a href="https://med-mastodon.com/tags/colorectalcancer" class="mention hashtag" rel="tag">#colorectalcancer</a>..<a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a> @OncoAlert@twitter.com

Manju George MVSc PhDA2: <a href="http://CRCMRD.com" target="_blank" rel="nofollow noopener noreferrer" translate="no">http://CRCMRD.com</a> is an informative website which highlights clinical trials for <a href="https://med-mastodon.com/tags/colorectalcancer" class="mention hashtag" rel="tag">#colorectalcancer</a> patients who have a positive <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> test result. <a href="https://crcmrd.com" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://crcmrd.com</a> <a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> @OncoAlert@twitter.com <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

Manju George MVSc PhDIn this <a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a>, we will 📌Review Session 1, CtDNA basics 📌Discuss use of ct🧬in stage IV CRC 📌Discuss enrolling ctDNA trials in stage IV CRC 📌Discuss the use ctDNA testing in novel clinical trial designs 📌Hear caregiver perspective on <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> testing @OncoAlert@twitter.com

Daniel Auclair, PhDHappy to share one of my latest collaborations on a new liquid biopsie approach that could prove more sensitive and informative than <a href="https://med-mastodon.com/tags/ctDNA" class="mention hashtag" rel="tag">#ctDNA</a> .MinimuMM-seq: <a href="https://med-mastodon.com/tags/genome" class="mention hashtag" rel="tag">#genome</a> sequencing of circulating tumor cells for minimally invasive molecular characterization of multiple <a href="https://med-mastodon.com/tags/myeloma" class="mention hashtag" rel="tag">#myeloma</a> pathology <a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0482/711479/MinimuMM-seq-Genome-sequencing-of-circulating" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0482/711479/MinimuMM-seq-Genome-sequencing-of-circulating</a>

Manju George MVSc PhDIn preparation of session #2 of the <a href="https://med-mastodon.com/tags/CtDNA" class="mention hashtag" rel="tag">#CtDNA</a> in CRC tweetchat, let's review what was covered in session 1.Q2. Practical considerations around ctDNA use in CRCSample ctDNA test type comparison @NateraOncology@twitter.com @GuardantHealth@twitter.com <a href="https://twitter.com/manjuggm/status/1583249204037750785?s=20&t=OBqW_Mj5yWdqc39toGTnAw" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/manjuggm/status/1583249204037750785?s=20&t=OBqW_Mj5yWdqc39toGTnAw</a><a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

Manju George MVSc PhDIn preparation of session #2 of the <a href="https://med-mastodon.com/tags/CtDNA" class="mention hashtag" rel="tag">#CtDNA</a> in CRC tweetchat tomorrow, let's review what was covered in session 1.Q2. Practical considerations around ctDNA use in <a href="https://med-mastodon.com/tags/colorectalcancer" class="mention hashtag" rel="tag">#colorectalcancer</a> <a href="https://twitter.com/manjuggm/status/1583249204037660672?s=20&t=cVLUzNcZGvB2J2QA_WqGig" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/manjuggm/status/1583249204037660672?s=20&t=cVLUzNcZGvB2J2QA_WqGig</a> <a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

Manju George MVSc PhDIn preparation of session #2 of the <a href="https://med-mastodon.com/tags/CtDNA" class="mention hashtag" rel="tag">#CtDNA</a> in CRC tweetchat tomorrow, let's review what was covered in session 1.Q2. Practical considerations around ctDNA use in <a href="https://med-mastodon.com/tags/colorectalcancer" class="mention hashtag" rel="tag">#colorectalcancer</a> <a href="https://twitter.com/JeanneTie/status/1583248952404721665?s=20&t=uxCKEel5QEOkIZSQGAAZkw" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/JeanneTie/status/1583248952404721665?s=20&t=uxCKEel5QEOkIZSQGAAZkw</a><a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

Manju George MVSc PhDIn preparation of session #2 of the <a href="https://med-mastodon.com/tags/CtDNA" class="mention hashtag" rel="tag">#CtDNA</a> in CRC tweetchat tomorrow, let's review what was covered in session 1.Q2. Practical considerations around ctDNA use in <a href="https://med-mastodon.com/tags/colorectalcancer" class="mention hashtag" rel="tag">#colorectalcancer</a> <a href="https://twitter.com/jonathanloree/status/1583248952542912517?s=20&t=Grw7QmbB2DK6Hfv7hiAkbg" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/jonathanloree/status/1583248952542912517?s=20&t=Grw7QmbB2DK6Hfv7hiAkbg</a> <a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

Manju George MVSc PhDIn preparation of session #2 of the <a href="https://med-mastodon.com/tags/CtDNA" class="mention hashtag" rel="tag">#CtDNA</a> in CRC tweetchat tomorrow, let's review what was covered in session 1. Q2. Practical considerations around ctDNA use in <a href="https://med-mastodon.com/tags/colorectalcancer" class="mention hashtag" rel="tag">#colorectalcancer</a> <a href="https://twitter.com/aparna1024/status/1583248700742189057?s=20&t=p5pwikjhzhcyc39zXus_3w" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://twitter.com/aparna1024/status/1583248700742189057?s=20&t=p5pwikjhzhcyc39zXus_3w</a><a href="https://med-mastodon.com/tags/CRCTrialsChat" class="mention hashtag" rel="tag">#CRCTrialsChat</a> <a href="https://med-mastodon.com/tags/CRCSM" class="mention hashtag" rel="tag">#CRCSM</a>

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