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Gaspar JekelyK.E. Machin in 1958 predicted that ciliary beat is NOT driven at the base, like in bacterial flagella (cilia are not whips) because then the wave would dye off towards the tip. He also predicted alternating activity of force generators across the axoneme. <a href="https://doi.org/10.1242/jeb.35.4.796" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1242/jeb.35.4.796</a>Jo Howard at "The Biophysics of Motile Cilia ‐ from Structure to Function" 830. WE-Heraeus-Seminar<a href="https://www.we-heraeus-stiftung.de/veranstaltungen/the-biophysics-of-motile-cilia-from-structure-to-function/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.we-heraeus-stiftung.de/veranstaltungen/the-biophysics-of-motile-cilia-from-structure-to-function/</a><a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://biologists.social/tags/biophysics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biophysics</a>

Gaspar JekelyMy presentation on "Coordination Across Scales — Or Why We Study Organisms" at the "Future 3D Additive Manufacturing – The 3DMM2O Conference" from today. <a href="https://jekelylab.github.io/3DMM2O_Kloster_Schoental_Mar_2025.html#/title-slide" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://jekelylab.github.io/3DMM2O_Kloster_Schoental_Mar_2025.html#/title-slide</a><a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://biologists.social/tags/larva" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#larva</a> <a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a>

Gaspar JekelyThe <a href="https://biologists.social/tags/goodnews" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#goodnews</a> for today is that <a href="https://biologists.social/tags/coral" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coral</a> larvae stop their <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> and contract, when the light goes off. How nice! <a href="https://www.biorxiv.org/content/10.1101/2025.02.06.636794v1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2025.02.06.636794v1</a><a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://biologists.social/tags/marine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#marine</a> <a href="https://biologists.social/tags/larva" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#larva</a>

Kirsty WanIn Chlamy, <a class="hashtag" href="https://bsky.app/search?q=%23cilia" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> are almost perfectly coordinated (in-phase) <a href="https://www.youtube.com/watch?v=WbpUzfpQNwk" rel="nofollow noopener noreferrer" target="_blank">www.youtube.com/watch?v=WbpU...</a> , allowing the cells to swim a fast breaststroke. In organisms with many more cilia (many thousands!) synchronised beating is no longer efficient, instead, metachronal coordination is the solution! 2/ <a href="https://www.youtube.com/watch?v=WbpUzfpQNwk" rel="nofollow noopener noreferrer" target="_blank">Chlamydomonas flagella beating...</a>

Gaspar JekelyWe published a new preprint on the biophysics of ciliary metachronal waves in the Platynereis larva. <a href="https://www.biorxiv.org/content/10.1101/2025.02.10.637311v2" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2025.02.10.637311v2</a> In collaboration with <a href="https://bsky.brid.gy/ap/did:plc:4r6khvkkt4wqz6iofl2eowsg" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@micromotility.bsky.social</a> and Rebecca Poon <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://biologists.social/tags/biophysics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biophysics</a> <a href="https://biologists.social/tags/platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#platynereis</a> 1/6

Kirsty WanNew preprint from Rebecca's PhD! did you know that the ciliary band metachronal wave in <a class="hashtag" href="https://bsky.app/search?q=%23Platynereis" rel="nofollow noopener noreferrer" target="_blank">#Platynereis</a> is a series of tiny waves within each multiciliated cell! What happens if you ablate some cilia?? 🌊😱 Cool <a class="hashtag" href="https://bsky.app/search?q=%23cilia" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> collab w/ <a class="mention" href="https://biologists.social/users/jekely" rel="nofollow noopener noreferrer" target="_blank">@jekely.biologists.social.ap.brid.gy</a>! Revealed here <a href="https://doi.org/10.1101/2025.02.10.637311" rel="nofollow noopener noreferrer" target="_blank">doi.org/10.1101/2025...</a>

Gaspar JekelyNew preprint from the lab on <a href="https://biologists.social/tags/coral" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coral</a> larval light responses, including ciliary arrests and body-wide contractions. Led by Emelie Brodrick, in collaboration with <a href="https://bsky.brid.gy/r/https://bsky.app/profile/micromotility.bsky.social" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@micromotility.bsky.social</a> <a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://respublicae.eu/@ERC_Research" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@ERC_Research</a> <a href="https://biologists.social/tags/hfsp" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hfsp</a> <a href="https://www.biorxiv.org/content/10.1101/2025.02.06.636794v1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2025.02.06.636794v1</a>

PLOS BiologyMC4R regulates <a href="https://fediscience.org/tags/BodyWeight" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BodyWeight</a> at hypothalamic neuronal <a href="https://fediscience.org/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a>, but its levels are normally v low. <a href="https://mstdn.social/@nachury" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@nachury</a> &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/40MWUUz" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/40MWUUz</a>

Human Technopole🔬Our <a href="https://bird.makeup/users/gaiapigino" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@gaiapigino</a> Group and <a href="https://bird.makeup/users/stefandiezlab" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@stefandiezlab</a> from <a href="https://wisskomm.social/@tudresden" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@tudresden</a> reveal how the "tubulin code" regulates bidirectional IFT train movement in <a href="https://mstdn.science/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a>, shedding light on ciliopathies and beyond. 📰Funded by <a href="https://bird.makeup/users/erc_research" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@erc_research</a> and <a href="https://bird.makeup/users/poldresden" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@poldresden</a> in <a href="https://bird.makeup/users/natcomms" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@natcomms</a> <a href="https://humantechnopole.it/en/news/the-tubulin-code-in-control-of-ift-train-motion/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://humantechnopole.it/en/news/the-tubulin-code-in-control-of-ift-train-motion/</a>

Bernhard SchermerOkay, let’s see if I understood this correctly and if it works: theoretically, my toots should now also be visible on Bluesky. If yes: Hello!!! So I’ll just add a few hashtags now and look forward to confirmation from the blue universe… 🦋 <a href="https://social.cologne/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://social.cologne/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> <a href="https://social.cologne/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a>

Gaspar JekelyThe movement of brain ependymal <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> was first described by Purkinje in 1836.Purkinje JE (1836) Ueber Flimmerbewegungen im Gehirn. Archiv für Anatomie, Physiologie und Wissenschaftliche Medicin (Müller) Jahrgang 1836, pp 289–291<a href="https://dl.ub.uni-freiburg.de/diglit/reichert1836/0005?sid=4c508554c282ebc7ae3362aa2e83f978" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://dl.ub.uni-freiburg.de/diglit/reichert1836/0005?sid=4c508554c282ebc7ae3362aa2e83f978</a><a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a>

Bernhard SchermerHeading back from the annual TheRaCil meeting 🚆Great reports, fruitful discussions, novel ideas and an amazing evening on the Seine in Paris. Special thanks to Sophie and the team in Paris for two productive and very valuable days! <a href="https://social.cologne/tags/Cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cilia</a> <a href="https://social.cologne/tags/Raredisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Raredisease</a> <a href="https://social.cologne/tags/ciliopathy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ciliopathy</a> <a href="https://social.cologne/tags/TheRaCil" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TheRaCil</a><a href="https://a.gup.pe/u/cilia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cilia</a>

Bernhard Schermer📣To all cilia enthusiasts who won’t be able to make it to Dublin: Registr. for online participation for <a href="https://social.cologne/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> 2024 is still open! To ensure that hybrid meetings continue in the future, it would be fantastic if as many people as possible could still register!The hybrid option comes with significant costs for the organizer! It was like this for <a href="https://social.cologne/tags/Cilia2022" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cilia2022</a>, and for <a href="https://social.cologne/tags/Cilia2024" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cilia2024</a> isn’t any better 🤷‍♂️Let’s make it as accessible as possible!<a href="https://cilia2024.ie/registration/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://cilia2024.ie/registration/</a> <a href="https://a.gup.pe/u/cilia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cilia</a>

Bernhard SchermerArrived! <a href="https://social.cologne/tags/Cilia2024" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cilia2024</a> about to start😊👍<a href="https://a.gup.pe/u/cilia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cilia</a> <a href="https://a.gup.pe/u/cellbio" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cellbio</a> <a href="https://social.cologne/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://social.cologne/tags/rarediseases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#rarediseases</a> <a href="https://social.cologne/tags/ciliopathies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ciliopathies</a> <a href="https://social.cologne/tags/centrosome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#centrosome</a>

Gaspar JekelyCheck this out <a href="https://qoto.org/@micromotility" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@micromotility</a>, our 'Excitability' paper is now a real classic! From 1820!! <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://biologists.social/tags/history" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#history</a> <a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a>

Bernhard Schermer📣 A new star is born in the cilia world and cell death galaxy: Emilia Kieckhöfer brilliantly defended her PhD today! Congratulations!!! 🎉🥳👍<a href="https://social.cologne/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://social.cologne/tags/necroptosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#necroptosis</a> <a href="https://social.cologne/tags/bbs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bbs</a> <a href="https://social.cologne/tags/raredisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#raredisease</a> <a href="https://social.cologne/tags/ciliopathies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ciliopathies</a> <a href="https://social.cologne/tags/celldeath" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#celldeath</a> <a href="https://social.cologne/tags/apoptosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#apoptosis</a> <a href="https://social.cologne/tags/kidney" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#kidney</a> <a href="https://social.cologne/tags/cysts" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cysts</a> <a href="https://social.cologne/tags/Nphp" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nphp</a> <a href="https://social.cologne/tags/Zilien" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Zilien</a><a href="https://a.gup.pe/u/cilia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cilia</a> <a href="https://social.cologne/@SFB1403" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@SFB1403</a> <a href="https://wisskomm.social/@CECAD" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@CECAD</a> <a href="https://wisskomm.social/@UniKoeln" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@UniKoeln</a>

Gaspar JekelyPress release at <a href="https://fediscience.org/@eLife" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@eLife</a> of our paper exploring the mechanism of pressure sensing by UV light sensors in <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Platynereis</a> larvae <a href="https://elifesciences.org/for-the-press/5f58b93c/plankton-use-uv-light-sensors-to-detect-pressure-change-and-avoid-getting-swept-away" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://elifesciences.org/for-the-press/5f58b93c/plankton-use-uv-light-sensors-to-detect-pressure-change-and-avoid-getting-swept-away</a>Luis Alberto Bezares Calderón et al. paper here: <a href="https://elifesciences.org/reviewed-preprints/94306" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://elifesciences.org/reviewed-preprints/94306</a><a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuroscience</a> <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a> <a href="https://biologists.social/tags/zooplankton" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#zooplankton</a> <a href="https://biologists.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#science</a> <a href="https://mander.xyz/c/biology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@biology</a>

Bernhard Schermer📣 Exciting update from the Nephrolab :koeln: Cologne:This preprint marks our debut in the BBS research area, presenting work of Emilia Kieckhöfer on cystic kidney disease in Bbs8 and potential mechanisms. A heartfelt thank you to Helen May-Simera and her team, along with all other contributors, for their invaluable support!<a href="https://www.biorxiv.org/content/10.1101/2024.03.07.583949v1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2024.03.07.583949v1</a><a href="https://social.cologne/tags/BBS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BBS</a> <a href="https://social.cologne/tags/Ciliopathy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Ciliopathy</a> <a href="https://social.cologne/tags/RareDisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RareDisease</a> <a href="https://social.cologne/tags/Nephrology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nephrology</a> <a href="https://social.cologne/tags/Kidney" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Kidney</a> <a href="https://social.cologne/tags/Nephrolab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nephrolab</a> <a href="https://social.cologne/tags/Cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cilia</a> <a href="https://social.cologne/tags/BardetBiedl" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BardetBiedl</a> <a href="https://social.cologne/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Science</a> <a href="https://social.cologne/tags/CellBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellBiology</a> <a href="https://social.cologne/tags/BBS8" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BBS8</a> <a href="https://a.gup.pe/u/cilia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cilia</a>

PLOS BiologyMaking <a href="https://fediscience.org/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a>. This study shows that the Cep131-Cep162 module near the <a href="https://fediscience.org/tags/axoneme" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#axoneme</a> and the Cby-Fam92 module near the <a href="https://fediscience.org/tags/membrane" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#membrane</a> work together to regulate localization of the <a href="https://fediscience.org/tags/ciliopathy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ciliopathy</a> protein Cep290 at the <a href="https://fediscience.org/tags/BasalBody" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BasalBody</a> to initiate ciliogenesis <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/49GCHCU" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/49GCHCU</a>

Stephen RoyleFantastic to see <a href="https://biologists.social/@David_Stephens" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@David_Stephens</a> recognised by the Royal Microscopy Society with a Scientific Achievement Award. Spanning <a href="https://biologists.social/tags/MembraneTraffic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MembraneTraffic</a> <a href="https://biologists.social/tags/cytoskeleton" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytoskeleton</a> and <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cilia</a>, work from his lab is always high quality. He's an inspirational scientist as the linked citation spells out.I've tagged him here although I'm sure he has better things to do than read Mastodon these days :) <a href="https://www.rms.org.uk/resource/professor-david-stephens-receives-rms-scientific-achievement-award.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.rms.org.uk/resource/professor-david-stephens-receives-rms-scientific-achievement-award.html</a>

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