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#TrainedImmunity

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eLife<p>Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago introduced the concept of <a href="https://fediscience.org/tags/TrainedImmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TrainedImmunity</span></a>.</p><p>Today, we invite research to a new Focus Issue on Trained Immunity. Find out more and spread the word. <a href="https://fediscience.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a><br><a href="https://elifesciences.org/inside-elife/e4eb2612/focus-issue-call-for-papers-in-trained-immunity?utm_source=mastodon&amp;utm_medium=social&amp;utm_campaign=organic" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/inside-elife</span><span class="invisible">/e4eb2612/focus-issue-call-for-papers-in-trained-immunity?utm_source=mastodon&amp;utm_medium=social&amp;utm_campaign=organic</span></a></p>
Gabriele Pollara<p>Nice papers that <a href="https://med-mastodon.com/tags/neutrophils" class="mention hashtag" rel="tag">#<span>neutrophils</span></a> can also be epigenetically reprogrammed by infection - stemming from effects on stem cells. </p><p>Both use <a href="https://med-mastodon.com/tags/zebrafish" class="mention hashtag" rel="tag">#<span>zebrafish</span></a> as model</p><p><a href="https://med-mastodon.com/tags/Shigella" class="mention hashtag" rel="tag">#<span>Shigella</span></a>: <a href="https://www.science.org/doi/full/10.1126/sciadv.adf9706" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/full/10.1126/s</span><span class="invisible">ciadv.adf9706</span></a> </p><p><a href="https://med-mastodon.com/tags/Salmonella" class="mention hashtag" rel="tag">#<span>Salmonella</span></a>: <a href="https://www.science.org/doi/10.1126/sciadv.adf9904" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/sciadv</span><span class="invisible">.adf9904</span></a> <br /><a href="https://med-mastodon.com/tags/trainedimmunity" class="mention hashtag" rel="tag">#<span>trainedimmunity</span></a> <a href="https://med-mastodon.com/tags/immunology" class="mention hashtag" rel="tag">#<span>immunology</span></a> <a href="https://med-mastodon.com/tags/epigenetics" class="mention hashtag" rel="tag">#<span>epigenetics</span></a></p>
Gabriele Pollara<p>Fascinating to see <a href="https://med-mastodon.com/tags/trainedimmunity" class="mention hashtag" rel="tag">#<span>trainedimmunity</span></a> used to condition immunomodulatory responses.</p><p>I guess it&#39;s about inducing the right <a href="https://med-mastodon.com/tags/epigenetic" class="mention hashtag" rel="tag">#<span>epigenetic</span></a> programme, and then the functional effect can be anything.<br /><a href="https://med-mastodon.com/tags/immunology" class="mention hashtag" rel="tag">#<span>immunology</span></a> <a href="https://med-mastodon.com/tags/macrophages" class="mention hashtag" rel="tag">#<span>macrophages</span></a> <span class="h-card" translate="no"><a href="https://mstdn.science/@JExpMed" class="u-url mention">@<span>JExpMed</span></a></span> <a href="https://med-mastodon.com/tags/tolerance" class="mention hashtag" rel="tag">#<span>tolerance</span></a> <a href="https://med-mastodon.com/tags/immunmodulation" class="mention hashtag" rel="tag">#<span>immunmodulation</span></a> <a href="https://med-mastodon.com/tags/science" class="mention hashtag" rel="tag">#<span>science</span></a><br /><a href="https://rupress.org/jem/article/220/11/e20221388/276204/Trained-immunity-of-alveolar-macrophages-enhances?guestAccessKey=6d53512f-5c93-4720-8180-9180f44cda67&amp;utm_source=NewJournalContent%27&amp;%27utm_campaign%27=%27JEM%27&amp;%27utm_medium%27=%27Email&amp;nbd=28080031447&amp;nbd_source=campaigner&amp;_ccCt=g843-2q1v95-cqesgb-cwe4ixj4" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">rupress.org/jem/article/220/11</span><span class="invisible">/e20221388/276204/Trained-immunity-of-alveolar-macrophages-enhances?guestAccessKey=6d53512f-5c93-4720-8180-9180f44cda67&amp;utm_source=NewJournalContent%27&amp;%27utm_campaign%27=%27JEM%27&amp;%27utm_medium%27=%27Email&amp;nbd=28080031447&amp;nbd_source=campaigner&amp;_ccCt=g843-2q1v95-cqesgb-cwe4ixj4</span></a></p>
Gabriele Pollara<p>More evidence of <a href="https://med-mastodon.com/tags/trainedimmunity" class="mention hashtag" rel="tag">#<span>trainedimmunity</span></a> in <a href="https://med-mastodon.com/tags/COVID19" class="mention hashtag" rel="tag">#<span>COVID19</span></a> / <a href="https://med-mastodon.com/tags/SarsCoV2" class="mention hashtag" rel="tag">#<span>SarsCoV2</span></a> infection leading to <a href="https://med-mastodon.com/tags/Hyperinflammation" class="mention hashtag" rel="tag">#<span>Hyperinflammation</span></a> </p><p><a href="https://med-mastodon.com/tags/immunology" class="mention hashtag" rel="tag">#<span>immunology</span></a> <a href="https://med-mastodon.com/tags/virology" class="mention hashtag" rel="tag">#<span>virology</span></a> <a href="https://med-mastodon.com/tags/infectiousdiseases" class="mention hashtag" rel="tag">#<span>infectiousdiseases</span></a> <a href="https://med-mastodon.com/tags/IDMastodon" class="mention hashtag" rel="tag">#<span>IDMastodon</span></a> <a href="https://med-mastodon.com/tags/medicine" class="mention hashtag" rel="tag">#<span>medicine</span></a> </p><p><a href="https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423007961%3Fshowall%3Dtrue" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">cell.com/cell/fulltext/S0092-8</span><span class="invisible">674(23)00796-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423007961%3Fshowall%3Dtrue</span></a></p>
Hao Yin<p>An impressive panorama of Trimethylamine N-oxide/TMAO on👤aortic <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EndothelialCell</span></a><br>⏫Traits of <a href="https://qoto.org/tags/TrainedImmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TrainedImmunity</span></a>/Inflammation<br>Metabolic reprogramming<br>Kinome &amp; transcriptional network</p><p>Intriguing role of PERK &amp; mitoROS</p><p>In addition to Liver, Aorta (<a href="https://qoto.org/tags/SmoothMuscleCell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SmoothMuscleCell</span></a>/#Pericyte/Fibroblast/Mɸ?) may🤔 also oxidize <a href="https://qoto.org/tags/GutMicrobiota" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GutMicrobiota</span></a>-derived trimethylamine/TMA into Trimethylamine N-oxide/TMAO </p><p>What is the local/Aortic vs circulating TMAO level?🧐</p><p>Wait for🐭tissue-specific KO of FMO3 (Oxidizing TMA)😆</p><p>Dr. Xiaofeng Yang lab JCI insight 2022<br><a href="https://insight.jci.org/articles/view/158183" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158183</span></a></p>
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