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#tirzepatide

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New Review and Meta-Analysis confirms weight gain with discontinuance of #Semaglutide and #Tirzepatide

Discontinuing GLP1 medications led to a pooled overall mean weight regain of 9.69 kg (or about 22 lbs in patients prescribed semaglutide/tirzepatide. The proportion of weight regained was proportional to the amount originally lost.

Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to #Obesity.

#wegovy #ozempic #mounjaro #zepbound
onlinelibrary.wiley.com/doi/10

Is this the FDA‘s backdoor to reduce the cost of drugs in America?

This opinion piece by Dr Scott Gottlieb, a Pfizer board member, may be biased towards the pharmaceutical industry 🤔

#FDA’s permissive stance on the compounding of GLP-1 drugs used for weight loss. Initially, the agency cited shortages of #semaglutide and #tirzepatide — the active ingredients in the popular drugs #Wegovy and #Zepbound — and allowed pharmacies to compound these drugs under a provision for addressing drug shortages.

#obesity #glp1
statnews.com/2024/11/19/fda-gl

#Obesity Drug Shows Promise in Easing Knee #Osteoarthritis Pain

As a practicing physician, I've seen up close the remarkable benefits of the #GLP1 class of medications, including #semaglutide (#Ozempic, #Wegovy) and #tirzepatide (#Mounjaro, #Zepbound.)

Reduction in weight (and inflammation) are game changers.

Better control of #Diabetes, reduced #Cardiovascular and #Stroke risk, maybe lower incident of #Dementia, #MultipleSclerosis and other diseases which have an 'inflammatory' component.

All we need now is to lower the cost (about $1,000/month in the US; heard the price is $59 in EU!)

nytimes.com/2024/10/30/health/

Tak jsem si udělal menší rešerši.

Podle #^https://www.sciencealert.com/one-type-of-fiber-could-have-weight-loss-benefits-similar-to-ozempic
by člověk měl do sebe dostat cca 25-30g betaglukanu denně. Ty jsou v kvasnicích, houbách a ovsi.

Extrakt z ovse
#^https://www.pangamin.cz/cardio-well-300g-50g-zdarma_z1540/
40g denně, tedy balení je na cca 10 dnů. Denní dávka stojí cca 40Kč.

Kvasnice
#^https://www.pangamin.cz/pangamin-klasik-sacek_z9/
Cca půlka hmotnosti buňky je betaglukan, takže balení s 90g stačí na cca 2 dny. Denní dávka stojí cca 45Kč.
(hrozně mi to páchne a nedělají to v tobolkách)

Oves
Betaglukanů je v ovsi cca 3-6% hmotnosti. Tzn. 0,5-1kg ovsa denně. 🐎🐴😱

Takže nic moc. Nic koncentrovanějšího jsem zatím nenašel.
Chtělo by to čistý betaglukan. Kdyby někdo měl chuť na startup. To je očividná díra na trhu...


#Betaglukan #Ozempic #Saxenda #Mounjaro #Semaglutide #Liraglutide #Tirzepatide
ScienceAlert · One Type of Fiber Could Have Weight Loss Benefits Similar to OzempicResearch on the gut microbiome has triggered a 'revolution' in nutritional science, and in the last few years, dietary fiber has become the "new protein" – added to foods in abundance to feed our gut and boost our health.

“You could argue this is just as important as the discovery of CPAP therapy 40 odd years ago,” referring to continuous positive airway pressure.

Why Curing Sleep Apnea Would Push Insurers to Pay for Weight-Loss Drugs

The New Holy Grail for Weight-Loss Drugs Is Sleep Apnea
Popular anti-obesity medicines are in testing for a range of other diseases. Positive results could prompt more insurers to pay up.

🎁🔗:
wsj.com/health/healthcare/slee