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ETIDIoHSource: Lancet Infectious Diseases, <a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00616-9/abstract?rss=yes" rel="nofollow noopener noreferrer" target="_blank">https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00616-9/abstract?rss=yes</a> Summary Background Yezo virus (YEZV) is an emerging tick-borne pathogen, which was initially reported in Japan in 2021. Only one patient had been reported in China so far. We aimed to describe the epidemiological, clinical, and laboratory findings of a series of patients, and to characterise the viral genomes of YEZV.Methods In this active surveillance and genomic analysis, we conducted active surveillance at Mudanjiang Forestry Central Hospital, Heilongjiang Province of northeast China. Participants were eligible for inclusion if they sought medical care for a recent tick bite between May 1 and July 31, in 2022 and 2023, and between May 1 and July 10, in 2024. We collected sera from participants to detect YEZV infection by meta-transcriptomic sequencing, real-time RT-PCR, and indirect immunofluorescence assay. We isolated YEZV by cell culture and characterised the pathogen by morphological and phylogenetic analyses.Findings A series of 18 patients with YEZV infection (12 male and six female; median age 53 years, IQR 45–60) were identified among 988 participants. The patients presented with fever (18 patients, 100%), headache (ten patients, 56%), dizziness (nine patients, 50%), malaise (three patients, 17%), lumbago (three patients, 17%), and cough (three patients, 17%). Nine (50%) patients had rash around the tick bite site and four (22%) had lymphadenopathy. Nine (50%) patients had gastrointestinal symptoms, and five (28%) had neurological symptoms. We observed leukopenia in ten (63%) and thrombocytopenia in five (31%) of 16 assessed patients. Elevated hepatic transaminase concentrations were identified in 13 (72%) of all 18 patients, lactate dehydrogenase or α-hydroxybutyric dehydrogenase in nine (50%), serum amyloid protein A in 13 (72%), and hypersensitive C-reactive protein in ten (56%). Eight (7%) of 119 Ixodes persulcatus ticks removed from participants were positive for YEZV. Three YEZV strains were isolated from the sera of patients. Ten viral genomes were obtained from five patients, a blood-sucking I persulcatus removed from a participant, and four host-questing tick samples collected in the areas where patients were identified or in the adjacent region. Phylogenetic analyses revealed that YEZVs in either patients or ticks were divided into two clades, each with distinct mutations.Interpretation Awareness of YEZV infection is important and clinicians should consider the virus when diagnosing patients with suitable symptoms.____<a href="https://etidioh.wordpress.com/2024/11/08/a-series-of-patients-infected-with-the-emerging-tick-borne-yezo-virus-in-china-an-active-surveillance-and-genomic-analysis/" class="" rel="nofollow noopener noreferrer" target="_blank">https://etidioh.wordpress.com/2024/11/08/a-series-of-patients-infected-with-the-emerging-tick-borne-yezo-virus-in-china-an-active-surveillance-and-genomic-analysis/</a><a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/abstract/" target="_blank">#abstract</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/arbovirus/" target="_blank">#ARBOVIRUS</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/china-2/" target="_blank">#china</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/health/" target="_blank">#health</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/news/" target="_blank">#news</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/research-2/" target="_blank">#research</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/tick-borne-infections-2/" target="_blank">#tickBorneInfections</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/ticks/" target="_blank">#ticks</a> <a rel="nofollow noopener noreferrer" class="hashtag u-tag u-category" href="https://etidioh.wordpress.com/tag/yezo-virus/" target="_blank">#yezoVirus</a>

Np9000<a href="https://mastodon.online/tags/PansPandasHour" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PansPandasHour</a> <a href="https://mastodon.online/tags/PANS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PANS</a> <a href="https://mastodon.online/tags/Anxiety" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Anxiety</a> <a href="https://mastodon.online/tags/EatingRestrictions" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EatingRestrictions</a> <a href="https://mastodon.online/tags/Lyme" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lyme</a> <a href="https://mastodon.online/tags/TickBorneInfections" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TickBorneInfections</a><a href="https://www.bayarealyme.org/blog/tick-borne-diseases-pans-pandas-and-resulting-pediatric-anxiety-and-eating-disorders/?fbclid=IwAR28Uz0C-fC3InWIVVPN21Zeifjw4ynV28B6Nek7LsElDirf_EvFWE0hP_U" rel="nofollow noopener noreferrer" target="_blank">https://www.bayarealyme.org/blog/tick-borne-diseases-pans-pandas-and-resulting-pediatric-anxiety-and-eating-disorders/?fbclid=IwAR28Uz0C-fC3InWIVVPN21Zeifjw4ynV28B6Nek7LsElDirf_EvFWE0hP_U</a>

Np9000So those dealing with <a href="https://mastodon.online/tags/PANS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PANS</a> <a href="https://mastodon.online/tags/PANDAS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PANDAS</a> <a href="https://mastodon.online/tags/Lyme" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lyme</a> <a href="https://mastodon.online/tags/Bartonella" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bartonella</a> <a href="https://mastodon.online/tags/TickborneInfections" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TickborneInfections</a> have known this for years, even decades. This study includes over 14,000 children. Is anyone else listening yet? Risk of major mental disorder after severe bacterial infection.<a href="https://pubmed.ncbi.nlm.nih.gov/36404700/" rel="nofollow noopener noreferrer" target="_blank">https://pubmed.ncbi.nlm.nih.gov/36404700/</a>

Np9000Hello! New to Mastodon like many of us. Thought I’d try a Toot.Raising awareness of <a href="https://mastodon.online/tags/PANS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PANS</a> <a href="https://mastodon.online/tags/PANDAS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PANDAS</a> <a href="https://mastodon.online/tags/Lyme" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lyme</a> <a href="https://mastodon.online/tags/Bartonella" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bartonella</a> <a href="https://mastodon.online/tags/TickBorneInfections" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TickBorneInfections</a> <a href="https://mastodon.online/tags/MECFS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MECFS</a> <a href="https://mastodon.online/tags/POTS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#POTS</a>. Does anyone know how long <a href="https://mastodon.online/tags/Debirdify" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Debirdify</a> takes? I’m trying to import my Twitter followers and followings but nothing has happened yet!

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