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#spikeprotein

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Zoomers of the Sunshine Coast

The COVID Spike Protein Is Playing Hide and Seek in Your Brain (And Winning)

Remember when we thought COVID was "just" a respiratory virus? Those were simpler times. Now, groundbreaking research shows the virus's spike protein can persist in brain tissue long after the virus itself is gone.

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episodes.fm/1769969487

Substack:
pubs.acs.org/doi/10.1021/jacs.

#COVID19#LongCOVID#SpikeProtein
Public *
Auscandoc

Breakthrough: Spike Proteins Persist in Brain for Years scitechdaily.com/long-covid-br “study reveals that the can persist in the brain’s protective layers (the meninges) and the skull’s bone marrow for up to four years after infection. This lingering spike protein may drive chronic inflammation and heighten the risk of neurodegenerative diseases.”

“the research also found that mRNA significantly reduce spike protein buildup in the brain.”

Public
beSpacific

#Scientists have discovered a #mutation in #SARS-CoV-2, the virus that causes #COVID19, that plays a key role in its ability to infect the central nervous system. The findings may help #scientists understand its #neurological symptoms and the mystery of #longCOVID and they could one day even lead to specific treatments to protect and clear the virus from the #brain. #medicine #publichealth #covid #spikeprotein medicalxpress.com/news/2024-08 #vaccines #healthcare

medicalxpress.comSpike mutations that help SARS-CoV-2 infect the brain discoveredScientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system. The findings may help scientists understand its neurological symptoms and the mystery of "long COVID," and they could one day even lead to specific treatments to protect and clear the virus from the brain.
Public
datum (n=1)

The paper's lead author said ““For those who have been diagnosed with COVID-19, we recommend you ask your ophthalmologist to check for signs of pathological changes to the retina. Even those who were asymptomatic could suffer from damage in the eyes over time because of COVID-19 associated complications.” [2]

The paper itself [1] shows - IN MICE - damage to the retina 30 days after #spikeProtein exposure (two 2-week infections a year, anyone?), blood-retina barrier (BRB) leakage, and outright "BRB cell death, which is further augmented by hyperglycemia", "intranasal exposure of SARS-CoV-2 activated ahyperinflammatory immune response in the retina", and SARS2 infects the BRB - all IN MICE.

But those sure do align, as they cite repeatedly, with human symptoms.

[1] journals.plos.org/plospathogen

[2] futurity.org/covid-19-virus-vi

h/t @rchusid

journals.plos.orgSARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposureAuthor summary SARS-CoV-2 is known to cause several ocular manifestations in COVID-19 patients; however, the role of eyes in viral transmission and ocular tissue tropism remains elusive. The presence of viral remnants in various ocular tissues and fluids from COVID-19 patients has led to an assumption that SARS-CoV-2 may be transmitted through the eyes. Here, we show that SARS-CoV-2 ocular tropism is through cells lining the BRB. SARS-CoV-2 not only infects the various parts of the eye via systemic exposure but also induces a hyperinflammatory immune and antiviral response in the retina. Unexpectedly, the corneal epithelium was found to be resistant to SARS-CoV-2 infection, and ocular exposure of SARS-CoV-2 failed to cause lung pathology and moribund illness. Cells lining the BRB showed induced expression of viral entry receptors and enhanced susceptibility towards SARS-CoV-2-induced cell death, which is further potentiated with comorbidities such as hyperglycemia. Our findings from this study shed light on the role of BRB in SARS-CoV-2 ocular tropism and the role of eyes in viral transmission.
#SARS2#covid#CovidIsNotOver
Public
Benjamin Carr, Ph.D. 👨🏻‍💻🧬

The next generation of #mRNAvaccines is on its way
Japan recently approved a new #mRNA #vaccine for #covid. And this one is pretty exciting. Just like the mRNA v#accines you know and love, it delivers the instructions for making the #virus’s #spikeprotein. But here’s what makes it novel: it also tells the body how to make more mRNA. Essentially, it provides instructions for making more instructions. It’s self-amplifying.
technologyreview.com/2024/02/0

MIT Technology Review · The next generation of mRNA vaccines is on its wayBy Cassandra Willyard
Public
Benjamin Carr, Ph.D. 👨🏻‍💻🧬

Global #COVID monitoring is crashing as BA.2.86 #COVIDvariant raises alarm
The number of mutations in #BA2.86's critical #spikeprotein is over 30, rivaling the number seen in the original omicron subvariant, #BA1, which went on to cause a tidal wave of cases and hospitalizations. The spike mutations appear geared toward evading neutralizing #antibody protections built up from past infections and #vaccinations.
"This is on the shoulders of governments right now." arstechnica.com/health/2023/08

Public
Steve Dustcircle 🌹

#COVID19 #mRNAvaccines don’t cause long-term #spikeprotein production in the body, contrary to claims by retired professor
healthfeedback.org/claimreview

Health FeedbackCOVID-19 mRNA vaccines don’t cause long-term spike protein production in the body, contrary to claims by retired professorGetting COVID-19 carries a greater risk of developing health complications compared to COVID-19 vaccination. COVID-19 mRNA vaccines contain messenger RNA (mRNA) that provides the blueprint for making spike protein. Modified mRNA isn’t intrinsically artificial. Modifications to mRNA also occur naturally in humans and are used to regulate gene expression. Scientists took their cue from nature when modifying COVID-19 vaccine mRNA to improve its stability and efficiency in protein synthesis.
Public
Eeeee Woooo

I’m at the #AAFSmeeting this week. In addition to sessions about my profession, there are good pathology sessions (sudden death is an interest of mine), and behavioral health sessions (the psychedelics are coming!).

My COVID brain fog is readily apparent to me, but I’m passing as coherent.

COVID19 isn’t done. And #COVID19 is a vascular disease that does weird-ass stuff.

I’m wearing my #spikeprotein shirt to celebrate that we have a great target in the SARS-CoV-2 virus.

Public
Infrapink (he/his/him)

Interesting paper. RNA G4-plexes are found in multiple cell surface proteins that bind the #SpikeProtein of #SARSCOV2, the virus that causes #COVID19. Blocking these sites in mice appears to significantly prevent #COVID viruses from entering cells, which makes it an attractive treatment option. And this can be accomplished with topotecan and berbamine, which are already approved for use in humans.

journals.plos.org/plospathogen

journals.plos.orgTargeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entryAuthor summary The rapid emergence of SARS-CoV-2 variants of concern, the complexity of infection, and the functional redundancy of host factors, underscore an urgent need for novel broad-spectrum antiviral strategies. RNA G-quadruplex (RG4), a non-canonical RNA secondary structure, has been recently implicated in the regulation of SARS-CoV-2 and host factors. Here, we further characterize the existence and functional importance of RG4s in several host factors, including ACE2. Moreover, we identify that Topotecan and Berbamine, two approved drugs, can function as RG4-stabilizing agents to repress RG4-containing host factors and protect cells and mice against SARS-CoV-2 pseudovirus entry. Together, this work highlights the significance of RG4 in SARS-CoV-2 pathogenesis and provide an attractive broad-spectrum antiviral strategy for COVID-19 prevention and control.
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