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katch wreck"These data show that a reversible depletion of <a href="https://mastodon.social/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> proteins can induce cancer in the absence of driver mutations, suggesting that tumours can emerge through <a href="https://mastodon.social/tags/epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetic</a> dysregulation leading to inheritance of altered cell fates"<a href="https://www.nature.com/articles/s41586-024-07328-w" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41586-024-07328-w</a><a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> <a href="https://mastodon.social/tags/oncology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#oncology</a>

The EMBO JournalSeung Kim, Frederick Dick et al show that resting <a href="https://sciencemastodon.com/tags/Bcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bcells</a> are uniquely sensitive to <a href="https://sciencemastodon.com/tags/EZH2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EZH2</a> <a href="https://sciencemastodon.com/tags/polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polycomb</a> complex inhibition, which activates expression of repetitive genomic elements and subsequent <a href="https://sciencemastodon.com/tags/innateimmune" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#innateimmune</a> receptor signaling in a form of viral mimicry<a href="https://www.embopress.org/doi/full/10.15252/embj.2023114462" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2023114462</a>

CavalliLabA famous <a href="https://mastodon.social/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> protein with roles in gene silencing but also activation!BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fateFront. Cell Dev. Biol., Volume 11 - 2023 <a href="https://doi.org/10.3389/fcell.2023.1146849" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.3389/fcell.2023.1146849</a>

CavalliLabPROTAC degraders Rock! Read this application to the <a href="https://mastodon.social/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> BMI and RING1B proteins: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy. <a href="https://doi.org/10.1002/advs.202205573" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1002/advs.202205573</a>

CavalliLabNew discoveries about <a href="https://mastodon.social/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> <a href="https://mastodon.social/tags/EZH2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EZH2</a> function in <a href="https://mastodon.social/tags/MultipleMyeloma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MultipleMyeloma</a> and a therapeutic avenue here: Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023). <a href="https://doi.org/10.1038/s41388-023-02618-5" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1038/s41388-023-02618-5</a>

The EMBO Journal<a href="https://sciencemastodon.com/tags/BRD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BRD4</a>-<a href="https://sciencemastodon.com/tags/PRC2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PRC2</a> represses <a href="https://sciencemastodon.com/tags/transcription" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcription</a> of T-helper 2-specific negative regulators during <a href="https://sciencemastodon.com/tags/Tcell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcell</a> <a href="https://sciencemastodon.com/tags/differentiation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#differentiation</a>: Brd4 interacts with <a href="https://sciencemastodon.com/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators <a href="https://sciencemastodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Foxp3</a> and E3 <a href="https://sciencemastodon.com/tags/ubiqutin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ubiqutin</a> <a href="https://sciencemastodon.com/tags/ligase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ligase</a> <a href="https://sciencemastodon.com/tags/Fbxw7" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Fbxw7</a> during lineage-specific differentiation of <a href="https://sciencemastodon.com/tags/Th2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Th2</a> cells from mouse primary naïve CD4+ T cells <a href="https://www.embopress.org/doi/10.15252/embj.2022111473" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/10.15252/embj.2022111473</a>

Gene Regulation1st weekly digest of <a href="https://genomic.social/tags/GeneRegulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GeneRegulation</a> papers:🧬<a href="https://genomic.social/tags/TranscriptionFactor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TranscriptionFactor</a> atlas of differentiation <a href="https://www.sciencedirect.com/science/article/pii/S0092867422014702" rel="nofollow noopener noreferrer" target="_blank">https://www.sciencedirect.com/science/article/pii/S0092867422014702</a>🧬 <a href="https://genomic.social/tags/TFbinding" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TFbinding</a> directed heterochromatin (<a href="https://genomic.social/tags/ZFP462" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ZFP462</a>) <a href="https://www.nature.com/articles/s41556-022-01051-2" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41556-022-01051-2</a>🧬<a href="https://genomic.social/tags/3Dgenome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#3Dgenome</a> organisation of nuclear speckles & splicing <a href="https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1</a>🧬 Nuclear partitioning by charge blocks (<a href="https://genomic.social/tags/MED1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MED1</a>, <a href="https://genomic.social/tags/PolII" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PolII</a>) <a href="https://www.sciencedirect.com/science/article/pii/S0092867422015264" rel="nofollow noopener noreferrer" target="_blank">https://www.sciencedirect.com/science/article/pii/S0092867422015264</a>🧬 Transient loss of <a href="https://genomic.social/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> induces an <a href="https://genomic.social/tags/epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetic</a> cancer fate <a href="https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1</a>🧬 RGT: a toolbox for NGS analysis <a href="https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1</a>

CavalliLab<a href="https://mastodon.social/tags/Epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Epigenetic</a> Alert: we posted a bioRxiv manuscript of exceptional interest (we think) ! Transient loss of <a href="https://mastodon.social/tags/Polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Polycomb</a> components induces an <a href="https://mastodon.social/tags/epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetic</a> <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> fate <a href="http://dlvr.it/SgPSrc" rel="nofollow noopener noreferrer" target="_blank">http://dlvr.it/SgPSrc</a> Brief thread follows, we are looking for feedback, thank you in advance!

PLOS BiologyA decline in ERK1/2 signaling promotes <a href="https://fediscience.org/tags/neural" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neural</a> <a href="https://fediscience.org/tags/differentiation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#differentiation</a> by regulating <a href="https://fediscience.org/tags/chromatin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chromatin</a> accessibility & <a href="https://fediscience.org/tags/polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polycomb</a> protein occupancy at neural genes in mouse embryo & in human neural precursors @katestorey27 @metzisv @briscoejames &co <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3OYGPF4" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3OYGPF4</a>

Mill_lab<a href="https://genomic.social/@EliasFriman" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@EliasFriman</a> Congratulations Elias & team Bickmore past and present! Amazing stuff on <a href="https://mstdn.social/tags/promoters" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#promoters</a>, <a href="https://mstdn.social/tags/enhancers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#enhancers</a> & ulltra-longe range interactions w/o <a href="https://mstdn.social/tags/cohensin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cohensin</a> and <a href="https://mstdn.social/tags/polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polycomb</a> across <a href="https://mstdn.social/tags/mESCs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mESCs</a>, mammalian and other cell types- excellent tweetorial- you should covert to a tootorial here!

Olga StepanovaHi <a href="https://genomic.social/tags/ScienceMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ScienceMastodon</a> 🔬 !✨ <a href="https://genomic.social/tags/introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#introduction</a> ✨ I'm a final year <a href="https://genomic.social/tags/PhD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PhD</a> student from Richard Meehan's lab at MRC HGU, University of Edinburgh 🏴󠁧󠁢󠁳󠁣󠁴󠁿 .In my project I'm investigating what roles <a href="https://genomic.social/tags/DNAmethylation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNAmethylation</a> and <a href="https://genomic.social/tags/polycomb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polycomb</a> play in <a href="https://genomic.social/tags/pluripotency" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pluripotency</a> and differentiation of mouse embryonic <a href="https://genomic.social/tags/stemcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#stemcells</a> 🐭 🧬 I'm a wet-lab biologist by training but I've been learning lots of <a href="https://genomic.social/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bioinformatics</a> recently and I'm hoping to do a <a href="https://genomic.social/tags/postdoc" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#postdoc</a> in Europe where I can combine both skillsets 🇪🇺

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