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Todas las semanas tenemos al menos un trabajo sobre los efectos de la contaminación en la fertilidad masculina. Hoy vienen dos, un disruptor endocrino y partículas de motor (modelos rodedor):
journals.plos.org/plosone/arti
sciencedirect.com/science/arti
#bianorbiotech #MaleFertility #rat #mouse #PM2.5 #octylphenol #pollution #EndocrineDisruptor

journals.plos.orgPM2.5 from automobile exhaust induces apoptosis in male rat germ cells via the ROS-UPR mt signaling pathwayObjective To explore the underlying mechanism behind the fine particulate matter’s (PM2.5)-mediated regulation of reproductive function in male rats, and to determine the role of vitamins in this process. Methods In all, 32 male SD rats were randomized to a control cohort (normal saline), a Vit cohort (vitamin C at 100 mg/kg + vitamin E at 50 mg/kg), a PM2.5 cohort (PM2.5 10 mg/kg), and a PM2.5 + Vit cohort (PM2.5 exposure + vitamin C at 100 mg/kg + vitamin E at 50 mg/kg), with eight rats in each cohort. After four weeks of exposure, mating experiments were carried out. Thereafter, rats were euthanized, and the testis and epididymis tissues were excised for hematoxylin-eosin (HE) staining and sperm quality analysis. Apoptosis of testis tissues was quantified via a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Moreover, the testicular oxidative stress (OS)-, apoptosis- and mitochondrial unfolded protein response (UPRmt)-related essential protein expressions were measured via western blotting (WB). Results After PM2.5 exposure, the sperm count and motility decreased, while sperm abnormality and the apoptosis index increased. HE staining showed that the number of spermatogenic cells decreased. WB showed that the PM2.5 group had decreased expressions of superoxide dismutase (SOD), nuclear factor E2-related factor 2 (Nrf2), and B-cell lymphoma-2 (Bcl-2) (p < 0.05), increased expressions of malondialdehyde (MDA), Bcl-2 associated X protein (Bax), and Caspase3 (p < 0.05), and downregulated expressions of C/EBP homologous protein (CHOP), heat shock protein 60 (HSP60), and activating transcription factor 5 (ATF5) (p < 0.05). These were all reversed by vitamin intervention. Conclusion PM2.5 from automobile exhaust disrupts male reproductive function. A combination of vitamins may protect reproductive function via the reactive oxygen species (ROS)-UPRmt signaling pathway.

"Air pollution
accounted for 8.1 million deaths globally in 2021, becoming the second leading risk factor for death, including for children under five years. Of the total deaths, noncommunicable diseases including heart disease, stroke, diabetes, lung cancer, and chronic obstructive pulmonary disease (COPD) account for nearly 90% of the disease burden from air pollution."

"In 2021, more than 700,000 deaths in children under 5 years were linked to air pollution; this represents 15% of all global deaths in children under five.'
State of Global Air Report 2024.
>>
stateofglobalair.org/resources
#air #Pollution #cars #COPD #PM2.5 #Particles #combustion

How #AirPollution is causing girls to get their first #periods earlier

New research shows that girls in the US are getting their first periods earlier. Exposure to toxic air is partly to blame.

By David Cox, June 4, 2024

"The same trend has also been noted around the world. South Korean scientists have described with some alarm how the number of girls displaying signs of precocious puberty – either breast development or #menstruation before the age of eight - increased 16-fold between 2008 and 2020.

"We're also seeing that these decreasing ages at puberty are even more pronounced in lower socioeconomic status groups, and ethnic minority groups," says Audrey Gaskins, an associate professor at Emory University in Atlanta, the US. "This has important implications for long-term health."

Researchers like Gaskins are primarily concerned that beginning puberty earlier might trigger a cascade of events which have far-reaching consequences later in adulthood. Emerging data suggests that it may not only curtail the fertility window, particularly if these women then enter menopause sooner, but shorten their lives. Precocious puberty has been repeatedly associated with a higher risk of diseases ranging from breast and ovarian cancers, metabolic syndromes such as obesity and type 2 diabetes, and cardiovascular disease."

By David Cox, June 4, 2024

"For several decades, scientists around the world have become increasingly concerned by signs that girls are entering puberty at a much younger age compared with previous generations.

From when girls experience their first period, something which scientists term the age of menarche, to commencing breast development, these seminal changes marking the onset of adolescence appear to be taking place progressively sooner.

"American girls today have been estimated to start menstruation up to four years earlier compared to girls living a century ago. In May, new data showed that while girls born between 1950 and 1969 typically began menstruating at 12.5 years, this decreased to an average of 11.9 years for the generation born in the early 2000s.

"The same trend has also been noted around the world. South Korean scientists have described with some alarm how the number of girls displaying signs of precocious puberty – either breast development or menstruation before the age of eight - increased 16-fold between 2008 and 2020.

"'We're also seeing that these decreasing ages at puberty are even more pronounced in lower socioeconomic status groups, and ethnic minority groups,' says Audrey Gaskins, an associate professor at Emory University in Atlanta, the US. 'This has important implications for long-term health.'

"Researchers like Gaskins are primarily concerned that beginning puberty earlier might trigger a cascade of events which have far-reaching consequences later in adulthood. Emerging data suggests that it may not only curtail the fertility window, particularly if these women then enter menopause sooner, but shorten their lives. Precocious puberty has been repeatedly associated with a higher risk of diseases ranging from breast and ovarian cancers, metabolic syndromes such as obesity and type 2 diabetes, and cardiovascular disease.

[...]

"Some of the major culprits appear to be #ToxicGases such as #SulphurDioxide, #NitrogenDioxide, #CarbonMonoxide and #ozone, all of which are released into the air either through #VehicleEmissions or waste produced by #Manufacturing Plants. In 2022, a study from scientists in Poland, a country known for its poor air quality due to the prevalence of #coal-burning factories, examined data from 1,257 women, and found a link between greater exposure to nitrogen gases and menstruation occurring before the age of 11."

Read more:
bbc.com/future/article/2024060

#PM2.5 #PM10 #ParticulateMatter #MaskUp #IndustrialAge

BBC · How air pollution is causing girls to get their first periods earlierBy David Cox