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"Air pollution has been linked to a swathe of lung cancer-driving DNA mutations, in a study of people diagnosed with the disease despite never having smoked tobacco.

The findings from an investigation into cancer patients around the world helps explain why those who have never smoked make up a rising proportion of people developing the cancer, a trend the researchers called an “urgent and growing global problem”.

Prof Ludmil Alexandrov, a senior author on the study at the University of California in San Diego, said researchers had observed the “problematic trend” but had not understood the cause.

“Our research shows that air pollution is strongly associated with the same types of DNA mutations we typically associate with smoking,” he said.

The scientists analysed the entire genetic code of lung tumours removed from 871 never-smokers in Europe, North America, Africa and Asia as part of the Sherlock-Lung study. They found that the higher the levels of air pollution in a region, the more cancer-driving and cancer-promoting mutations were present in residents’ tumours.

Fine-particulate air pollution was in particular linked to mutations in the TP53 gene. These have previously been associated with tobacco smoking."

theguardian.com/science/2025/j

The Guardian · Air pollution linked to lung cancer-driving DNA mutations, study findsBy Ian Sample

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MAGA = Make Asbestos Great Again?

“ Trump's support for asbestos has been welcomed in Russia, a primary asbestos supplier to the US. In 2018, a Russian asbestos company began marketing asbestos with Trump's face and a seal reading "Approved by Donald Trump, 45th President of the United States."

arstechnica.com/health/2025/06

Snopes: Trump Faced Russian Asbestos.
snopes.com/fact-check/russian-

Ars Technica · Trump’s EPA to “reconsider” ban on cancer-causing asbestosBy Beth Mole
"Mini-organ" boosts immune responses: so called tertiary lymphoid structures (TLS) are catalysators of the immune system. These round structures have an inner core of antigen-presenting cells and a broader rim of effector T cells. The presence of TLS is associated with treatment response to #immunotherapy in various cancers (e.g. #sarcoma, #melanoma, #lungcancer). But what triggers their existence? And: how can the neo-formation of TLS be triggered in cancer patients? Inducing TLS formation could be an exciting new avenue for immunotherpies, read more in our article here:

https://www.nature.com/articles/s41392-025-02260-5

#science #Oncology #immunology

The mystery rise of lung cancer in non-smokers

Lung cancer doesn't only affect smokers. As the number of smokers is declining, the proportion of lung cancer cases occurring in people who have never smoked is increasing. This type of cancer differs from that of smokers. And female non-smokers are twice as likely to develop it as men who never smoked. So, what causes it? I explored this topic in my piece for BBC Future.

#cancer #lungcancer #airpollution #cleanair

bbc.com/future/article/2025060

BBC · The mystery rise of lung cancer in non-smokersBy Theres Lüthi