The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #Chemistry #ChemBio
We suggest which protein kinases (like CK1 and CK2) are involved (see bonus post 
!).
These are key enzymes ensuring everything runs in sync in humans too, making O. tauri an intriguing example of efficient biological timing.
#Kinase #Phosphorylation 5/7
eLife Special Issue
A specially curated collection of articles untangles the bewildering complexity of #kinase enzymes.
https://elifesciences.org/collections/eb7614d5/special-issue-allosteric-regulation-of-kinase-activity?utm_source=mastodon&utm_medium=social&utm_campaign=organic
The Raf #kinase #inhibitors #Dabrafenib and #Regorafenib impair #Zika virus #replication via distinct mechanisms, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00618-24?af=R
This study provides further insight into ZIKV-host interactions and has implications for the development of novel #antivirals against ZIKV and possibly other #flaviviruses.
Study reveals how a #sugar_sensing #protein acts as a 'machine' to switch #plant #growth—and #oil production—on and off
#kinase #KIN10 #trehalose_6_phosphate
https://phys.org/news/2024-05-reveals-sugar-protein-machine-growth.html
Researchers uncover natural variation in wild #emmer #wheat for broad-spectrum #disease resistance.
#immunity #agriculture #powdery_mildew #transmembrane #kinase #WTK7_TM #Pm36
https://phys.org/news/2024-04-uncover-natural-variation-wild-emmer.html
Location, location, location: Protein #kinase nanoclustering for optimised signalling output. https://elifesciences.org/articles/93902?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Postdoc - Kinase biology and signalling
Barts Cancer Institute
Join @DrTanyaSoliman 's team @QMBCI #postdoc #kinase
See the full job description on jobRxiv: https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917
#cell_biology #kinases #mass_spectrometry #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/barts-cancer-institute-27778-postdoc-kinase-biology-and-signalling/?feed_id=71917
Death by a thousand cuts through #kinase inhibitor combinations that can more selectively inhibit individual or multiple protein #kinases than single inhibitors. https://elifesciences.org/articles/86189?utm_source=mastodon&utm_medium=social&utm_campaign=organic
This “highly interesting” study adds a new layer to our mechanistic understanding of the complex #Parkinson’s disease-linked LRRK2 #kinase. https://elifesciences.org/articles/87098?utm_source=mastodon&utm_medium=social&utm_campaign=organic
pYtags enable spatiotemporal measurements of receptor tyrosine #kinase signalling in living cells, with enzymes shown here rapidly moving from the cytosol to the cell membranes. #12DaysOfeLife https://elifesciences.org/articles/82863?utm_source=mastodon&utm_medium=social&utm_campaign=organic_12days
In developing #presynapses, the #ActiveZone structure assembles via liquid-liquid #PhaseSeparation (#LLPS). This study shows that the #kinase SAD-1 phosphorylates the scaffold protein SYD-2/Liprin-α, relieving autoinhibition & triggering LLPS #PLOSBiology https://plos.io/3Ne6OZg
"Here, we demonstrate that damaged #lysosomal #membranes are repaired by #microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC #kinase STK38 as a novel microlysophagy regulator...microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing #aging."
Are you interested in #Calmodulin (CaM) and its interaction with CaMKII? We had a look at this interaction with #photocrosslinking. Covalent attachment of CaM did not break apart the CaMKII holoenzyme but did promote ongoing #kinase activity. The CaM binding segment is also more mobile than expected from previous reports.
This is the accepted pdf, a long time in the making as you might detect.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.4798
Researchers shed light on the molecular activation of the #MAP #kinase #p38α #cytokine storm 'switch'.
https://phys.org/news/2023-09-molecular-kinase-p38-cytokine-storm.html
#PLK1 and #PP2A-B56 form a bifunctional #kinase-#phosphatase module that balances mitotic #checkpoint strength and #kinetochore-#microtubule attachment dynamics
#RefereedPreprint c/o @ReviewCommons by Andrea Corno, Adrian Saurin et al
Our latest work is out now in @Circ_Gen! 
️Genetic variants in #TNNI3K are associated with dilated cardiomyopathy and supraventricular arrhythmias
#DCM #Arrhythmia #Genetics #Kinase #cardiology Big big thanks to all co-authors! @_CarolinePham Karolina Andrzejczyck, @JurgensSean, @steven_lubitz, @patrick_ellinor, @Jael_Copier, @ArthurWilde5, @cbezzina1, @eml314 and others 
https://www.ahajournals.org/doi/abs/10.1161/CIRCGEN.122.003975
https://www.science.org/doi/10.1126/sciadv.adf2331
"The ectopic activation of ERK in scar-prone injuries induced a pro-regenerative response, including cell proliferation, extracellular matrix remodeling, and hair follicle neogenesis. Our data detail an important distinction in ERK activity between regenerating and poorly regenerating adult mammals and open avenues to redirect fibrotic repair toward regenerative healing"
Receptor-interacting serine/threonine kinase 2 (RIPK2) is a dual-specific kinase downstream of NODs signaling pathway. RIPK2 plays important roles in both innate and adaptive immunities. This review summarizes the recent works in developing RIPK2 inhibitors and degraders. We also briefly describe RIPK2 structure and its functions.
https://www.frontiersin.org/articles/10.3389/fphar.2023.1127722/full
