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#immunecheckpointblockade

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Arjan Boltjes<p>" Instead, <a href="https://mastodon.social/tags/Hepatoblastoma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Hepatoblastoma</span></a> <a href="https://mastodon.social/tags/tumors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tumors</span></a> contain a large suppressive <a href="https://mastodon.social/tags/myeloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>myeloid</span></a> compartment which poses opportunities for targeting. Specifically, therapeutic antibodies<br>targeting the <a href="https://mastodon.social/tags/tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tumor</span></a> antigen <a href="https://mastodon.social/tags/GPC3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GPC3</span></a> to induce ADCP by <a href="https://mastodon.social/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>macrophages</span></a>, in combination with myeloid<br><a href="https://mastodon.social/tags/ImmuneCheckpointBlockade" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneCheckpointBlockade</span></a> (<a href="https://mastodon.social/tags/CD47" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CD47</span></a>/SIRPa, or VISTA) could be a feasible strategy to explore in future studies"</p><p>Krijgsman et al. from Vercoulen lab in the <a href="https://mastodon.social/tags/UMCUtrecht" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>UMCUtrecht</span></a>, on <a href="https://mastodon.social/tags/bioRXiv" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bioRXiv</span></a>:<br><a href="https://www.biorxiv.org/content/10.1101/2023.06.28.546852v1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">23.06.28.546852v1</span></a></p><p><a href="https://mastodon.social/tags/scRNAseq" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>scRNAseq</span></a> <a href="https://mastodon.social/tags/spatial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>spatial</span></a> <a href="https://mastodon.social/tags/CyTOF" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CyTOF</span></a> <a href="https://mastodon.social/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a></p>
Claire McCarthy<p>Check out some <a href="https://mstdn.social/tags/CoolScienceImages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CoolScienceImages</span></a> from a Nature Communications study on <a href="https://mstdn.social/tags/fluorescencefriday" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fluorescencefriday</span></a>. Nikolos et al. showed that an iDAMP blockade approach synergizes with <a href="https://mstdn.social/tags/chemotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>chemotherapy</span></a> and sensitizes <a href="https://mstdn.social/tags/bladdercancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bladdercancer</span></a> to <a href="https://mstdn.social/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunotherapy</span></a> in <a href="https://mstdn.social/tags/preclinicalmodels" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>preclinicalmodels</span></a>. </p><p><a href="https://www.nature.com/articles/s41467-022-29026-9" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-022</span><span class="invisible">-29026-9</span></a></p><p>Music: Baby Don’t Hurt Me by David Guerra, Anne-Marie, &amp; Coi Leray</p><p><a href="https://mstdn.social/tags/CancerMoonshot" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CancerMoonshot</span></a><br><a href="https://mstdn.social/tags/CancerMoonshotSeminar" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CancerMoonshotSeminar</span></a><br><a href="https://mstdn.social/tags/CMSSChan" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CMSSChan</span></a><br><a href="https://mstdn.social/tags/cancerresearch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancerresearch</span></a><br><a href="https://mstdn.social/tags/ImmuneCheckpointBlockade" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneCheckpointBlockade</span></a></p>
Judit Svensson Arvelund<p>Cool paper dissecting the mechanism of action of <a href="https://masto.ai/tags/immunecheckpointblockade" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunecheckpointblockade</span></a>, anti-CTLA-4, and showing the important role of <a href="https://masto.ai/tags/myeloidcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>myeloidcells</span></a> <a href="https://masto.ai/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>macrophages</span></a> </p><p>"Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling"</p><p><a href="https://masto.ai/tags/naturecancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>naturecancer</span></a> <a href="https://masto.ai/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunotherapy</span></a> <a href="https://masto.ai/tags/immunecheckpointinhibitor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunecheckpointinhibitor</span></a> <a href="https://masto.ai/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>macrophages</span></a> <a href="https://masto.ai/tags/IFNI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>IFNI</span></a></p><p><a href="https://www.nature.com/articles/s43018-022-00447-1" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s43018-022</span><span class="invisible">-00447-1</span></a></p>
Hao Yin<p><a href="https://qoto.org/tags/Senescence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Senescence</span></a> <a href="https://qoto.org/tags/ImmuneSurveillance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneSurveillance</span></a> <br>Next-gen <a href="https://qoto.org/tags/Senolytic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Senolytic</span></a></p><p><a href="https://qoto.org/tags/ImmuneCheckpointBlockade" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ImmuneCheckpointBlockade</span></a> activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells-&gt;<br>⏬adverse phenotypes in🐭<a href="https://qoto.org/tags/Aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Aging</span></a>+<a href="https://qoto.org/tags/NASH" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NASH</span></a></p><p>Dr. Yoshikazu Johmura &amp; Makoto Nakanishi labs Nature 2022<br><a href="https://www.nature.com/articles/s41586-022-05388-4" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41586-022</span><span class="invisible">-05388-4</span></a></p>
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