"Zombie" #COVID19 fragments linger for some, causing severe disease outcomes, new research reveals

A new finding could be the reason why some people have long COVID or die from SARS-CoV-2

By Nicole Karlis
Published February 2, 2024 3:02PM (EST)

"This suggested that more serious COVID-19 outcomes are a result of these leftover fragments that are essentially overstimulating the immune system."

https://www.salon.com/2024/02/02/zombie-19-fragments-linger-for-some-causing-severe-disease-outcomes-new-research-reveals/

Pharmacological #inhibition of TBK1/IKKε blunts #immunopathology in a murine model of #SARS-CoV-2 infection https://www.nature.com/articles/s41467-023-41381-9 #research #science #covid19 #hyperinflammation

Importance of noting all clinical observations, even when not intended -> discovery of metoprolol as an IL-6 antagonist... (well, inhibition of IL-6 translation).

Therapeutic benefit in CAR-T cell-associated cytokine release syndrome (CRS).

Intriguing in vitro effect limited to stimulation by CAR-T lysate & not LPS. Hard to know if experiments really comparable, in terms of timing and stimulus

@JExpMed #immunology #hematology #Science #medicine #Hyperinflammation

https://rupress.org/jem/article/220/11/e20230577/276186/IL-6-translation-is-a-therapeutic-target-of-human?guestAccessKey=14c26a84-b641-4702-bc77-aa191b8e3af1&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2py049-cq1cho-cwe4ixj0

More evidence of #trainedimmunity in #COVID19 / #SarsCoV2 infection leading to #Hyperinflammation

#immunology #virology #infectiousdiseases #IDMastodon #medicine

https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423007961%3Fshowall%3Dtrue

Secukinumab blocks IL-17 and some evidence of efficacy in hidradenitis suppurativa in 2x RCT.

Interesting in so much this is clearly an inflammatory disease in which there is also undoubtedly an infective component.

These studies, along with efficacy of TNF blockade indicates hyperinflammation the main issue.

#immunology #inflammation #hidradenitis #IL17 #secukinumab #RCT #trial #hyperinflammation

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00022-3/fulltext?dgcid=raven_jbs_aip_email

Pretty stunning paper proposing a mechanism for #MIS-C in children post-Covid-19.

Genetic deficiency in OAS–RNase L promotes myeloid cell cytokine production +++.

#COVID19 #immunology #inflammation #hyperinflammation #science #ScienceMastodon

https://www.science.org/doi/10.1126/science.abo3627

Time to introduce myself. I am a mother of two. Head of a pediatric intensive care unit and active in a consultant team responsible for Picu and NICU. my interests are #Immunology, #Hyperinflammation,#Misc and #PedsICU