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Diane<a href="https://xoxo.zone/@marcprecipice" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@marcprecipice</a> I'm curious as to who voted for <a href="https://octodon.social/tags/hla" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hla</a> 404media had a story about angry nextdoor comments, but I'm really curious what kinds of people were happy for HLA passing.Looking at yesonhla endorsements I'm guessing a lot of college educated climate alarmed people were involved, but I don't think that's enough for a 63% yes.I'm hoping someone publishes a precinct level results file for HLA.

Monika Wolkers<a href="https://www.biorxiv.org/content/10.1101/2023.09.03.556079v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.09.03.556079v1</a><a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a> <a href="https://mstdn.science/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a> <a href="https://mstdn.science/tags/Antigen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Antigen</a> <a href="https://mstdn.science/tags/ML" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ML</a> <a href="https://mstdn.science/tags/prediction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#prediction</a>

Matt WillemsenGene variant carried by 1 in 5 people may guard against Alzheimer's and Parkinson's, massive study finds An immune-related gene variant has been tied to a reduced risk of Alzheimer's and Parkinson's across a huge, diverse population of people. <a href="https://www.livescience.com/health/alzheimers-dementia/gene-variant-carried-by-1-in-5-people-may-guard-against-alzheimers-and-parkinsons-massive-study-finds" rel="nofollow noopener noreferrer" target="_blank">https://www.livescience.com/health/alzheimers-dementia/gene-variant-carried-by-1-in-5-people-may-guard-against-alzheimers-and-parkinsons-massive-study-finds</a> <a href="https://fedibird.com/tags/alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alzheimers</a> <a href="https://fedibird.com/tags/parkinsons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#parkinsons</a> <a href="https://fedibird.com/tags/genetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#genetics</a> <a href="https://fedibird.com/tags/protection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#protection</a> <a href="https://fedibird.com/tags/immunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunity</a> <a href="https://fedibird.com/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a>

Victoria Stuart 🇨🇦 🏳️‍⚧️Gene variation may explain immunity from COVID-19 <a href="https://www.sciencedaily.com/releases/2023/07/230719112613.htm" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencedaily.com/releases/2023/07/230719112613.htm</a>People with COVID-19 who never develop symptoms >2x as likely as those who become symptomatic to carry a gene variation that helps them obliterate the virusA common allele of HLA is associated with asymptomatic SARS-CoV-2 infection <a href="https://www.nature.com/articles/s41586-023-06331-x" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41586-023-06331-x</a>HLA-B*15:01 is carried by ~10% of the study population It doesn't prevent the virus f. infecting cells but prevents people f. developing any symptoms<a href="https://mastodon.social/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> <a href="https://mastodon.social/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a>

Sterling EricssonAs with organ transplants, stem cells trigger an immune response when used in medical treatments, potentially leading to rejection of the cells.To prevent this, Sana Biotechnology scientists have developed stem cells with removed HLA markers that survived uninhibited in rhesus macaques for months.This opens up whole new prospects for medical treatment of organs and tissues.<a href="https://mstdn.science/tags/Medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medicine</a> <a href="https://mstdn.science/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Science</a> <a href="https://mstdn.science/tags/Biotech" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biotech</a> <a href="https://mstdn.science/tags/Biotechnology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biotechnology</a> <a href="https://mstdn.science/tags/StemCell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#StemCell</a> <a href="https://mstdn.science/tags/StemCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#StemCells</a> <a href="https://mstdn.science/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a> <a href="https://mstdn.science/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biology</a> <a href="https://mstdn.science/tags/Scicomm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Scicomm</a><a href="https://www.nature.com/articles/s41587-023-01784-x" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41587-023-01784-x</a>

Mark Patterson, MD, PhDAn interesting new article suggests that there is an association between those with <a href="https://med-mastodon.com/tags/narcolepsy" class="mention hashtag" rel="tag">#narcolepsy</a> and other <a href="https://med-mastodon.com/tags/HLA" class="mention hashtag" rel="tag">#HLA</a>-related <a href="https://med-mastodon.com/tags/autoimmune" class="mention hashtag" rel="tag">#autoimmune</a> disorders. <a href="https://www.sciencedirect.com/science/article/abs/pii/S138994572300093X?dgcid=raven_sd_aip_email" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.sciencedirect.com/science/article/abs/pii/S138994572300093X?dgcid=raven_sd_aip_email</a>

Kerry J. Laing, PhD<a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> folks—we are hunting for <a href="https://mstdn.science/tags/cloned" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cloned</a> <a href="https://mstdn.science/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a> cDNAs and coming up empty for HLA-A*66:01. Does anyone know a source to acquire this before we burn hours to isolate/clone it ourselves or spend $$$ to have it synthesized?

Monika Wolkers<a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mstdn.science/tags/KIRs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#KIRs</a> <a href="https://mstdn.science/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a> recognition <a href="https://mstdn.science/tags/innate" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#innate</a>: really exciting paper: <a href="https://www.biorxiv.org/content/10.1101/2023.02.06.527249v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.02.06.527249v1</a>

Thiago Carvalho"Detrimental combinations were associated with cytotoxic immune response in primary tumors, while metastases showed signs of immune evasion and ineffective antitumor immunity. On the contrary, beneficial combinations were associated with an active cytotoxic immune response only in metastatic samples."<a href="https://qoto.org/tags/Preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Preprint</a> <a href="https://qoto.org/tags/HLA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HLA</a> <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> <a href="https://qoto.org/tags/TumorImmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunity</a><a href="https://www.biorxiv.org/content/10.1101/2022.11.16.516740v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2022.11.16.516740v1</a>

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