Jan R. Boehnke<p>I think this is a next/ remaining frontier for pragmatic <a href="https://mastodon.social/tags/RCTs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>RCTs</span></a> in this area and the concept of <a href="https://mastodon.social/tags/Estimands" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Estimands</span></a> could potentially help here, as an approach to link several elements for trial and intervention planning<br><a href="https://jpro.springeropen.com/articles/10.1186/s41687-020-00218-5" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">jpro.springeropen.com/articles</span><span class="invisible">/10.1186/s41687-020-00218-5</span></a></p><p>While the intervention should not be planned to fit a trial, it is clearly possible to develop an intervention with an outcome in mind and theorise about the direction and size/relevance of expected effects.</p>