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#endocannabinoid

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CITO Greenhouse<p>Exploring the Brain: A Journey Through Neuroimaging and Neural Dynamics</p><p><a href="https://mastodon.social/tags/BrainScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BrainScience</span></a> <a href="https://mastodon.social/tags/Neuroimaging" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroimaging</span></a> <a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroscience</span></a> <a href="https://mastodon.social/tags/BrainHealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BrainHealth</span></a> <a href="https://mastodon.social/tags/Microglia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Microglia</span></a> <a href="https://mastodon.social/tags/Synapses" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Synapses</span></a> <a href="https://mastodon.social/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a> <a href="https://mastodon.social/tags/Neurochemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurochemistry</span></a> <a href="https://mastodon.social/tags/BrainArchitecture" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BrainArchitecture</span></a> <a href="https://mastodon.social/tags/Memory" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Memory</span></a> <a href="https://mastodon.social/tags/Cognition" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cognition</span></a> <a href="https://mastodon.social/tags/MoodRegulation" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MoodRegulation</span></a> <a href="https://mastodon.social/tags/Neurotherapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurotherapy</span></a> <a href="https://mastodon.social/tags/BrainConnectivity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BrainConnectivity</span></a> <a href="https://mastodon.social/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MentalHealth</span></a> <a href="https://mastodon.social/tags/NeuroscienceExplained" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NeuroscienceExplained</span></a></p><p><a href="https://youtube.com/shorts/JBEXN3VIQ5I?feature=share" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">youtube.com/shorts/JBEXN3VIQ5I</span><span class="invisible">?feature=share</span></a></p>
katch wreck<p>`Here we report that high expression of astrocytic cannabinoid receptor 1 (CB1) in the nucleus accumbens (NAc) shell, particularly in the end-feet ensheathing blood vessels, is associated with resilience during chronic social stress in adult male mice. Viral-mediated overexpression of Cnr1 in astrocytes of the NAc shell results in baseline anxiolytic effects and dampens stress-induced anxiety- and depression-like behaviors in male mice.`</p><p> <a href="https://www.nature.com/articles/s41593-025-01891-9" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41593-025</span><span class="invisible">-01891-9</span></a></p><p><a href="https://mastodon.social/tags/BBB" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BBB</span></a> <a href="https://mastodon.social/tags/brain" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>brain</span></a> <a href="https://mastodon.social/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>endocannabinoid</span></a></p>
Xamanismo Coletivo<p>"<a href="https://hachyderm.io/tags/CarlSagan" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CarlSagan</span></a>, the astronomer &amp; science communicator, speculated that <a href="https://hachyderm.io/tags/cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabis</span></a> might be the 1st ever domesticated plant, the one that drove the dawn of <a href="https://hachyderm.io/tags/agriculture" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>agriculture</span></a>. The <a href="https://hachyderm.io/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>endocannabinoid</span></a> system, that regulates other systems in the human body, is where <a href="https://hachyderm.io/tags/Cannabinoids" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabinoids</span></a> like <a href="https://hachyderm.io/tags/THC" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>THC</span></a> fit like a lock &amp; a key. This is how foundational a relationship can get… you have to love that plant a whole lot to create agriculture simply to have a steady supply."<br><a href="https://pca.st/wjj3qblb?t=20m8s" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="">pca.st/wjj3qblb?t=20m8s</span><span class="invisible"></span></a></p>
DoomsdaysCW<p><a href="https://kolektiva.social/tags/Cannabinoids" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabinoids</span></a> as novel <a href="https://kolektiva.social/tags/AntiInflammatory" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AntiInflammatory</span></a> drugs</p><p>by Prakash Nagarkatti, et al.<br>October, 2009</p><p>Abstract:</p><p>"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (<a href="https://kolektiva.social/tags/THC" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>THC</span></a>) as the major psychoactive principle in marijuana, as well as the identification of <a href="https://kolektiva.social/tags/cannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabinoid</span></a> receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on <a href="https://kolektiva.social/tags/immune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immune</span></a> cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate <a href="https://kolektiva.social/tags/cytokine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cytokine</span></a> and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress <a href="https://kolektiva.social/tags/inflammatory" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>inflammatory</span></a> responses. The <a href="https://kolektiva.social/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>endocannabinoid</span></a> system is also involved in <a href="https://kolektiva.social/tags/immunoregulation" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immunoregulation</span></a>. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."</p><p>Executive summary</p><p>- Cannabinoids, the active components of <a href="https://kolektiva.social/tags/CannabisSativa" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CannabisSativa</span></a>, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).</p><p>- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.</p><p>- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.</p><p>- Cannabinoids have been tested in several experimental models of autoimmune disorders such as <a href="https://kolektiva.social/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MultipleSclerosis</span></a>, <a href="https://kolektiva.social/tags/RheumatoidArthritis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RheumatoidArthritis</span></a>, <a href="https://kolektiva.social/tags/colitis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>colitis</span></a> and <a href="https://kolektiva.social/tags/hepatitis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hepatitis</span></a> and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.</p><p>- Cannabinoids may also be beneficial in certain types of <a href="https://kolektiva.social/tags/cancers" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cancers</span></a> that are triggered by <a href="https://kolektiva.social/tags/ChronicInflammation" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ChronicInflammation</span></a> In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.</p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ncbi.nlm.nih.gov/pmc/articles/</span><span class="invisible">PMC2828614/</span></a></p>
Manni_P :mastolove:<p><a href="https://troet.cafe/tags/Newsteam" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Newsteam</span></a> <a href="https://troet.cafe/tags/Baerbock" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Baerbock</span></a> <a href="https://troet.cafe/tags/Annalena" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Annalena</span></a> <a href="https://troet.cafe/tags/Thunberg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Thunberg</span></a> <a href="https://troet.cafe/tags/Greta" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Greta</span></a> <a href="https://troet.cafe/tags/texttospeech" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>texttospeech</span></a> <a href="https://troet.cafe/tags/GretaThunberg" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>GretaThunberg</span></a> <a href="https://troet.cafe/tags/AnnalenaBaerbock" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AnnalenaBaerbock</span></a> <a href="https://troet.cafe/tags/Hamas" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Hamas</span></a> <a href="https://troet.cafe/tags/Gr%C3%BCne" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Grüne</span></a> <a href="https://troet.cafe/tags/WochenzeitungZeit" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>WochenzeitungZeit</span></a> <a href="https://troet.cafe/tags/LuisaNeubauer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>LuisaNeubauer</span></a> <a href="https://troet.cafe/tags/NLEmarsy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NLEmarsy</span></a> <a href="https://troet.cafe/tags/Israel" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Israel</span></a> <a href="https://troet.cafe/tags/Politik" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Politik</span></a> </p><p>Damit wir alle die gleiche Basis für eine faire <a href="https://troet.cafe/tags/Debatte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Debatte</span></a> haben - hier die notwendigen <a href="https://troet.cafe/tags/Grundlagen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Grundlagen</span></a>, um zu verstehen.<br><a href="https://www.youtube.com/watch?v=WXN9EuQsz8w" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=WXN9EuQsz8</span><span class="invisible">w</span></a><br>Das <a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a>-System hilft, alle physiologischen Systeme zu regulieren und stellt sicher, dass sie in <a href="https://troet.cafe/tags/Harmonie" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Harmonie</span></a> miteinander arbeiten. Diesen Zustand nennt man <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a> <a href="https://troet.cafe/tags/Luisa" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Luisa</span></a></p>
Manni_P :mastolove:<p><a href="https://www.youtube.com/watch?v=WXN9EuQsz8w" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=WXN9EuQsz8</span><span class="invisible">w</span></a></p><p><span class="h-card"><a href="https://squeet.me/profile/deutschlandfunk" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>deutschlandfunk</span></a></span> BITTE DAS VIDEO AUF EVIDENZ PRÜFEN lieben Dank! 😍 :ablobcool: 👯 </p><p>Das <a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a>-System hilft, alle physiologischen Systeme zu regulieren und stellt sicher, dass sie in <a href="https://troet.cafe/tags/Harmonie" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Harmonie</span></a> miteinander arbeiten. Diesen Zustand nennt man <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a> </p><p><a href="https://troet.cafe/tags/Bayern" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bayern</span></a> <a href="https://troet.cafe/tags/Lauterbach" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Lauterbach</span></a> <a href="https://troet.cafe/tags/Papst" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Papst</span></a> <a href="https://troet.cafe/tags/Epigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Epigenetics</span></a> <a href="https://troet.cafe/tags/Scholz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Scholz</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/S%C3%B6der" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Söder</span></a> <a href="https://troet.cafe/tags/Aiwanger" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Aiwanger</span></a> <a href="https://troet.cafe/tags/Bundespolizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundespolizei</span></a> <a href="https://troet.cafe/tags/Bundesregierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundesregierung</span></a> <a href="https://troet.cafe/tags/Gesundheit" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Gesundheit</span></a> <a href="https://troet.cafe/tags/Medizin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Medizin</span></a> <a href="https://troet.cafe/tags/Polizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Polizei</span></a> <a href="https://troet.cafe/tags/evangelisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>evangelisch</span></a> <a href="https://troet.cafe/tags/katholisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>katholisch</span></a> <a href="https://troet.cafe/tags/Kirche" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Kirche</span></a><br>@fff@chaos.social<br><span class="h-card"><a href="https://norden.social/@Norden" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>Norden</span></a></span><br><span class="h-card"><a href="https://toot.cm-social.com/@CriticalMassElmshorn" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>CriticalMassElmshorn</span></a></span> 👍</p>
Manni_P :mastolove:<p><a href="https://www.youtube.com/watch?v=WXN9EuQsz8w" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=WXN9EuQsz8</span><span class="invisible">w</span></a></p><p><span class="h-card"><a href="https://gruene.social/@GrueneBundestag" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>GrueneBundestag</span></a></span> deshalb lasst ihr weiter Menschen jagen und blubbert seit Jahren herum Pfui ...</p><p>Das <a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a>-System hilft, alle physiologischen Systeme zu regulieren und stellt sicher, dass sie in <a href="https://troet.cafe/tags/Harmonie" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Harmonie</span></a> miteinander arbeiten. Diesen Zustand nennt man <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a></p><p><a href="https://troet.cafe/tags/Bayern" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bayern</span></a> <a href="https://troet.cafe/tags/Lauterbach" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Lauterbach</span></a> <a href="https://troet.cafe/tags/Papst" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Papst</span></a> <a href="https://troet.cafe/tags/Epigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Epigenetics</span></a> <a href="https://troet.cafe/tags/Scholz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Scholz</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/S%C3%B6der" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Söder</span></a> <a href="https://troet.cafe/tags/Aiwanger" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Aiwanger</span></a> <a href="https://troet.cafe/tags/Bundespolizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundespolizei</span></a> <a href="https://troet.cafe/tags/Bundesregierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundesregierung</span></a> <a href="https://troet.cafe/tags/Gesundheit" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Gesundheit</span></a> <a href="https://troet.cafe/tags/Medizin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Medizin</span></a> <a href="https://troet.cafe/tags/Polizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Polizei</span></a> <a href="https://troet.cafe/tags/evangelisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>evangelisch</span></a> <a href="https://troet.cafe/tags/katholisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>katholisch</span></a> <a href="https://troet.cafe/tags/Kirche" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Kirche</span></a> <a href="https://troet.cafe/tags/Missbrauch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Missbrauch</span></a><br><a href="https://troet.cafe/tags/letztegeneration" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>letztegeneration</span></a></p>
Manni_P :mastolove:<p><a href="https://www.youtube.com/watch?v=WXN9EuQsz8w" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=WXN9EuQsz8</span><span class="invisible">w</span></a><br><span class="h-card"><a href="https://ard.social/@tagesschau" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>tagesschau</span></a></span> Damit wir alle die gleiche Basis für eine faire <a href="https://troet.cafe/tags/Debatte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Debatte</span></a> haben - hier die notwendigen <a href="https://troet.cafe/tags/Grundlagen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Grundlagen</span></a>, um zu verstehen.</p><p>Das <a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a>-System hilft, alle physiologischen Systeme zu regulieren und stellt sicher, dass sie in <a href="https://troet.cafe/tags/Harmonie" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Harmonie</span></a> miteinander arbeiten. Diesen Zustand nennt man <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a> </p><p><a href="https://troet.cafe/tags/Bayern" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bayern</span></a> <a href="https://troet.cafe/tags/Lauterbach" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Lauterbach</span></a> <a href="https://troet.cafe/tags/Papst" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Papst</span></a> <a href="https://troet.cafe/tags/Epigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Epigenetics</span></a> <a href="https://troet.cafe/tags/Scholz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Scholz</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/S%C3%B6der" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Söder</span></a> <a href="https://troet.cafe/tags/Aiwanger" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Aiwanger</span></a> <a href="https://troet.cafe/tags/Bundespolizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundespolizei</span></a> <a href="https://troet.cafe/tags/Bundesregierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundesregierung</span></a> <a href="https://troet.cafe/tags/Gesundheit" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Gesundheit</span></a> <a href="https://troet.cafe/tags/Medizin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Medizin</span></a> <a href="https://troet.cafe/tags/Polizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Polizei</span></a> <a href="https://troet.cafe/tags/evangelisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>evangelisch</span></a> <a href="https://troet.cafe/tags/katholisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>katholisch</span></a> <a href="https://troet.cafe/tags/Kirche" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Kirche</span></a></p>
Manni_P :mastolove:<p><a href="https://www.youtube.com/watch?v=WXN9EuQsz8w" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=WXN9EuQsz8</span><span class="invisible">w</span></a></p><p><a href="https://troet.cafe/tags/CANNABIS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CANNABIS</span></a></p><p>Damit wir alle die gleiche Basis für eine faire <a href="https://troet.cafe/tags/Debatte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Debatte</span></a> haben. Hier die notwendigen <a href="https://troet.cafe/tags/Grundlagen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Grundlagen</span></a>, um zu verstehen.</p><p>Das <a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a>-System hilft, alle physiologischen Systeme zu regulieren und stellt sicher, dass sie in <a href="https://troet.cafe/tags/Harmonie" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Harmonie</span></a> miteinander arbeiten. Dieser Zustand heißt <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a> </p><p><a href="https://troet.cafe/tags/Bayern" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bayern</span></a> <a href="https://troet.cafe/tags/Lauterbach" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Lauterbach</span></a> <a href="https://troet.cafe/tags/Papst" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Papst</span></a> <a href="https://troet.cafe/tags/Epigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Epigenetics</span></a> <a href="https://troet.cafe/tags/Scholz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Scholz</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/S%C3%B6der" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Söder</span></a> <a href="https://troet.cafe/tags/Aiwanger" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Aiwanger</span></a> <a href="https://troet.cafe/tags/Bundespolizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundespolizei</span></a> <a href="https://troet.cafe/tags/Bundesregierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundesregierung</span></a> <a href="https://troet.cafe/tags/fridaysforfuture" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fridaysforfuture</span></a> <a href="https://troet.cafe/tags/letztegeneration" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>letztegeneration</span></a> <a href="https://troet.cafe/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroscience</span></a> <a href="https://troet.cafe/tags/Research" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Research</span></a> <a href="https://troet.cafe/tags/Wahrheit" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Wahrheit</span></a></p>
Manni_P :mastolove:<p><a href="https://www.youtube.com/watch?v=WXN9EuQsz8w" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">youtube.com/watch?v=WXN9EuQsz8</span><span class="invisible">w</span></a></p><p>Damit wir alle die gleiche Basis für eine faire <a href="https://troet.cafe/tags/Debatte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Debatte</span></a> haben - hier die notwendigen <a href="https://troet.cafe/tags/Grundlagen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Grundlagen</span></a>, um zu verstehen.</p><p>Das <a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a>-System hilft, alle physiologischen Systeme zu regulieren und stellt sicher, dass sie in <a href="https://troet.cafe/tags/Harmonie" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Harmonie</span></a> miteinander arbeiten. Diesen Zustand nennt man <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a> </p><p><a href="https://troet.cafe/tags/Bayern" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bayern</span></a> <a href="https://troet.cafe/tags/Lauterbach" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Lauterbach</span></a> <a href="https://troet.cafe/tags/Papst" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Papst</span></a> <a href="https://troet.cafe/tags/Epigenetics" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Epigenetics</span></a> <a href="https://troet.cafe/tags/Scholz" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Scholz</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/S%C3%B6der" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Söder</span></a> <a href="https://troet.cafe/tags/Aiwanger" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Aiwanger</span></a> <a href="https://troet.cafe/tags/Bundespolizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundespolizei</span></a> <a href="https://troet.cafe/tags/Bundesregierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundesregierung</span></a> <a href="https://troet.cafe/tags/Gesundheit" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Gesundheit</span></a> <a href="https://troet.cafe/tags/Medizin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Medizin</span></a> <a href="https://troet.cafe/tags/Polizei" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Polizei</span></a> <a href="https://troet.cafe/tags/evangelisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>evangelisch</span></a> <a href="https://troet.cafe/tags/katholisch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>katholisch</span></a> <a href="https://troet.cafe/tags/Kirche" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Kirche</span></a> <a href="https://troet.cafe/tags/Missbrauch" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Missbrauch</span></a></p>
pacanukeha❌ (seasonally appropriate remix)<p>" *There's an Important Reason Disturbed <a href="https://mstdn.ca/tags/Sleep" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Sleep</span></a> Makes Everything Hurt More* " - <span class="h-card" translate="no"><a href="https://universeodon.com/@ScienceAlert" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>ScienceAlert</span></a></span> <br><a href="https://mstdn.ca/tags/Science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Science</span></a> <a href="https://mstdn.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Pain</span></a> <a href="https://mstdn.ca/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a> <a href="https://mstdn.ca/tags/Neurology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neurology</span></a><br><a href="https://www.sciencealert.com/theres-an-important-reason-disturbed-sleep-makes-everything-hurt-more" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sciencealert.com/theres-an-imp</span><span class="invisible">ortant-reason-disturbed-sleep-makes-everything-hurt-more</span></a></p>
Benjamin Carr, Ph.D. 👨🏻‍💻🧬<p>Give <a href="https://hachyderm.io/tags/roundworms" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>roundworms</span></a> some weed and they’ll get the munchies, study finds<br>Work could further our understanding of <a href="https://hachyderm.io/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>endocannabinoid</span></a> system, help drug development. <br>C. elegans, also experiences the munchies when dosed with <a href="https://hachyderm.io/tags/cannabinoids" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabinoids</span></a>, according to a new paper published in the journal Current Biology. We suspect it's not a coincidence that the paper was released on April 20. <br><a href="https://arstechnica.com/science/2023/04/give-a-roundworm-some-weed-and-hell-get-the-munchies-study-finds/" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">arstechnica.com/science/2023/0</span><span class="invisible">4/give-a-roundworm-some-weed-and-hell-get-the-munchies-study-finds/</span></a></p>
Manni_P :mastolove:<p>+++ <a href="https://troet.cafe/tags/Anslinger" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Anslinger</span></a> +++</p><p><a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a> <a href="https://troet.cafe/tags/system" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>system</span></a> <a href="https://troet.cafe/tags/acts" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>acts</span></a> as a <a href="https://troet.cafe/tags/regulator" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>regulator</span></a> of <a href="https://troet.cafe/tags/immune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immune</span></a> <a href="https://troet.cafe/tags/homeostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>homeostasis</span></a> <a href="https://troet.cafe/tags/Weedmob" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Weedmob</span></a> <a href="https://troet.cafe/tags/Cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabis</span></a> <a href="https://troet.cafe/tags/Wissen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Wissen</span></a> <a href="https://troet.cafe/tags/Klagen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Klagen</span></a> <a href="https://troet.cafe/tags/Rassismus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Rassismus</span></a> <a href="https://troet.cafe/tags/Menschenrechte" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Menschenrechte</span></a> <br><a href="https://troet.cafe/tags/FridaysForFuture" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>FridaysForFuture</span></a> <a href="https://troet.cafe/tags/Cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabis</span></a>:<a href="https://troet.cafe/tags/Hanf" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Hanf</span></a> <a href="https://troet.cafe/tags/TomorrowIsTooLate" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TomorrowIsTooLate</span></a> <a href="https://troet.cafe/tags/UrLiebe" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>UrLiebe</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/luisa" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>luisa</span></a> <a href="https://troet.cafe/tags/greta" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>greta</span></a> <a href="https://troet.cafe/tags/onelove" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>onelove</span></a> <a href="https://troet.cafe/tags/biggerthanus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biggerthanus</span></a> <br>Beweisaufnahme: <a href="https://troet.cafe/@Lost_Paradise/109787336288711856" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">troet.cafe/@Lost_Paradise/1097</span><span class="invisible">87336288711856</span></a><br>Gerichtsfestes Wissen: <a href="https://troet.cafe/@Lost_Paradise/110000895301085411" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">troet.cafe/@Lost_Paradise/1100</span><span class="invisible">00895301085411</span></a><br><a href="https://troet.cafe/tags/Legalisierung2023" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Legalisierung2023</span></a> <a href="https://troet.cafe/tags/Weedmob" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Weedmob</span></a> <a href="https://troet.cafe/tags/Legalisierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Legalisierung</span></a> <a href="https://troet.cafe/tags/fff" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>fff</span></a> <a href="https://troet.cafe/tags/antipro" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>antipro</span></a> <a href="https://troet.cafe/tags/lto" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>lto</span></a> <a href="https://troet.cafe/tags/hartaberfair" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hartaberfair</span></a> <a href="https://troet.cafe/tags/AnneWill" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>AnneWill</span></a> <a href="https://troet.cafe/tags/Cannabiscommunity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Cannabiscommunity</span></a> <a href="https://troet.cafe/tags/Hanf" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Hanf</span></a></p>
Manni_P :mastolove:<p><a href="https://troet.cafe/tags/Epigenetik" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Epigenetik</span></a> - <a href="https://troet.cafe/tags/Immunsystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Immunsystem</span></a> - <a href="https://troet.cafe/tags/Endocannabinoidsystem" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoidsystem</span></a> - <a href="https://troet.cafe/tags/Neuroprotektion" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroprotektion</span></a> - <a href="https://troet.cafe/tags/Neuroplastizit%C3%A4t" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Neuroplastizität</span></a> - <a href="https://troet.cafe/tags/Traumata" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Traumata</span></a> </p><p>Welche <a href="https://troet.cafe/tags/Zusammenh%C3%A4nge" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Zusammenhänge</span></a> gibt es? Gibt es <a href="https://troet.cafe/tags/Verkn%C3%BCpfungen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Verknüpfungen</span></a>?</p><p><a href="https://troet.cafe/tags/Metabolismus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Metabolismus</span></a> <a href="https://troet.cafe/tags/Hom%C3%B6ostase" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Homöostase</span></a> <a href="https://troet.cafe/tags/Entz%C3%BCndungen" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Entzündungen</span></a> <a href="https://troet.cafe/tags/Heilung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Heilung</span></a></p><p>Hanf hilft Hanf heilt Hanf lindert</p><p><a href="https://troet.cafe/tags/NAZIS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NAZIS</span></a> <a href="https://troet.cafe/tags/T%C3%96TEN" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>TÖTEN</span></a> <a href="https://troet.cafe/tags/WEGEN" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>WEGEN</span></a> <a href="https://troet.cafe/tags/BUBATZ" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>BUBATZ</span></a></p><p>Warum lässt die <a href="https://troet.cafe/tags/Bundesregierung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Bundesregierung</span></a> das zu?</p><p><a href="https://troet.cafe/tags/weedmob" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>weedmob</span></a> <a href="https://troet.cafe/tags/cannabis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabis</span></a> <a href="https://troet.cafe/tags/cannabinoide" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cannabinoide</span></a> <a href="https://troet.cafe/tags/menschenjagd" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>menschenjagd</span></a> <a href="https://troet.cafe/tags/hexenverfolgung" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>hexenverfolgung</span></a> </p><p><a href="https://www.pnas.org/doi/10.1073/pnas.1612177114" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">pnas.org/doi/10.1073/pnas.1612</span><span class="invisible">177114</span></a><br>- - - &gt;<br><a href="https://troet.cafe/tags/Endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Endocannabinoid</span></a> <a href="https://troet.cafe/tags/system" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>system</span></a> <a href="https://troet.cafe/tags/acts" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>acts</span></a> as a <a href="https://troet.cafe/tags/regulator" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>regulator</span></a> of <a href="https://troet.cafe/tags/immune" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immune</span></a> <a href="https://troet.cafe/tags/homeostasis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>homeostasis</span></a> ... <a href="https://troet.cafe/tags/onelove" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>onelove</span></a></p>
KarenK<p><a href="https://mstdn.ca/tags/MMJ" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>MMJ</span></a> <a href="https://mstdn.ca/tags/autism" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>autism</span></a> <a href="https://mstdn.ca/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>endocannabinoid</span></a></p><p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0165178121005515" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sciencedirect.com/science/arti</span><span class="invisible">cle/abs/pii/S0165178121005515</span></a></p>
Verena Straub<p>I guess I’ll give this a go <a href="https://mstdn.science/tags/Introduction" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Introduction</span></a><br>I’m a 3rd year PhD student trying to untangle the mystery that is <a href="https://mstdn.science/tags/endocannabinoid" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>endocannabinoid</span></a> transport in the group of Mario van der Stelt in beautiful <a href="https://mstdn.science/tags/Leiden" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Leiden</span></a>. <br>I studied <a href="https://mstdn.science/tags/biochemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biochemistry</span></a> at Heidelberg University and got interested in all things <a href="https://mstdn.science/tags/DrugDiscovery" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DrugDiscovery</span></a> and <a href="https://mstdn.science/tags/ChemicalBiology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>ChemicalBiology</span></a> while spending some time in <a href="https://mstdn.science/tags/Oxford" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Oxford</span></a>. I have been fairly inactive on the birdsite but will try to be more active on here!</p>