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#DeepMutationalScanning

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Jochen Weile<p>Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic libraries. <br>Our pre-print is now available: <a href="https://www.biorxiv.org/content/10.1101/2023.02.22.529427v1" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">23.02.22.529427v1</span></a></p><p><span class="h-card"><a href="https://genomic.social/@fritzroth" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>fritzroth</span></a></span> <br><a href="https://qoto.org/tags/pacbio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pacbio</span></a> <a href="https://qoto.org/tags/Bioinformatics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bioinformatics</span></a> <a href="https://qoto.org/tags/DeepMutationalScanning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DeepMutationalScanning</span></a> <a href="https://qoto.org/tags/BarSeq" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BarSeq</span></a> <a href="https://qoto.org/tags/VariantEffectMapping" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>VariantEffectMapping</span></a> <a href="https://qoto.org/tags/longread" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>longread</span></a> <a href="https://qoto.org/tags/mave" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mave</span></a></p>
Jochen Weile<p>I figure I should also make an introduction. I'm an RA in the Roth Lab at UofT and I work on Multiplexed Assays of Variant Effects and their use toward clinical variant interpretation. <a href="https://qoto.org/tags/variantclassification" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>variantclassification</span></a> <a href="https://qoto.org/tags/deepmutationalscanning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>deepmutationalscanning</span></a> <a href="https://qoto.org/tags/bioinformatics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bioinformatics</span></a> <a href="https://qoto.org/tags/systemsbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>systemsbiology</span></a> <a href="https://qoto.org/tags/computationalbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>computationalbiology</span></a> <a href="https://qoto.org/tags/moleculargenetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>moleculargenetics</span></a></p>
Matthew Wakefield 🧬<p><a href="https://genomic.social/tags/introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>introduction</span></a><br>Hi, I am Matthew and currently work on <a href="https://genomic.social/tags/ovarian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ovarian</span></a> <a href="https://genomic.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to <a href="https://genomic.social/tags/PARP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PARP</span></a> inhibitors.<br>Currently this is involving lots of <a href="https://genomic.social/tags/FunctionalGenomics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>FunctionalGenomics</span></a> with <a href="https://genomic.social/tags/MAVE" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MAVE</span></a> assays and <a href="https://genomic.social/tags/DMS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DMS</span></a> (<a href="https://genomic.social/tags/DeepMutationalScanning" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DeepMutationalScanning</span></a>) to dissect protein complex interactions with inhibitors.<br>I mainly do <a href="https://genomic.social/tags/ComputationalBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ComputationalBiology</span></a> and supervise a team that does the wet work.<br>Trying to create a focused work engagement in this account</p>
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