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#CureIPF

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Will Oldham<p>Pleased to share that the lab has landed its first R01 to study the role of lactate transport as a potential metabolic vulnerability in pulmonary fibrosis! </p><p><a href="https://med-mastodon.com/tags/cureIPF" class="mention hashtag" rel="tag">#<span>cureIPF</span></a></p>
KaminskiMed :verified:<p>8/n last - Study funding was by @boehringerus@twitter.com <a href="https://med-mastodon.com/tags/DiscoveryAward" class="mention hashtag" rel="tag">#<span>DiscoveryAward</span></a> to @Farida_Ahangari@twitter.com &amp; by @nih_nhlbi@twitter.com to me &amp; others, also supported by institutional cores, colleagues, patient advocates, sample &amp; tissue donors <br />Thank you all!!!<br /><a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>7/n So grateful to the team, led by Dr. Ahangari, <a href="https://med-mastodon.com/tags/KaminskiLab" class="mention hashtag" rel="tag">#<span>KaminskiLab</span></a> members, so many selfless collaborators including Drs Fernández-Hernando, Price, Dela Cruz, Prasse, Ivan Rosas, &amp; Bahal (<a href="https://bahal.lab.uconn.edu/" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="">bahal.lab.uconn.edu/</span><span class="invisible"></span></a> that designed PNA-33) <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>6/n Pharmacologic inhibition of miR-33 using PNA-33 in precision-cut lung slices obtained from bleomycin-injured mice or humans with IPF, also indicated antifibrotic effects, including reversal of profibrotic macrophage signature <br /><a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>5/n Impressively, loss of Mir-33 in myeloid cells, has an effect on alveolar type II cells, their mitochondrial homeostasis improved and apoptosis ⬇️<br /><a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>4/n Loss of miR-33 in macrophages improves mitochondrial homeostasis (function and structure) at baseline and after bleomycin injury, ⬆️ autophagy and mitophagy <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>3/n Knocking down miR-33 genetically in myeloid cells, or pharmacologically using a Peptide Nucleic Acid inhibitor designed by Dr. Bahal (PNA-33) protects mice against bleomycin-induced Pulmonary Fibrosis<br /><a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>2/n We first show that miR-33 is increased in BAL and lung cells obtained from IPF patients and that miR-33 target genes are decreased in IPF <br /><a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/miR33PFPaper" class="mention hashtag" rel="tag">#<span>miR33PFPaper</span></a><br /><a href="https://insight.jci.org/articles/view/158100" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">insight.jci.org/articles/view/</span><span class="invisible">158100</span></a></p>
KaminskiMed :verified:<p>Intriguing! Connections between air pollution, and DNA methylation in IPF. Kudos Drs Dr. Goobie, Zhang &amp; team<br /><a href="https://med-mastodon.com/tags/CleanAir" class="mention hashtag" rel="tag">#<span>CleanAir</span></a> <br /><a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <br /><a href="https://www.sciencedirect.com/science/article/abs/pii/S0269749122021571" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">sciencedirect.com/science/arti</span><span class="invisible">cle/abs/pii/S0269749122021571</span></a></p>
KaminskiMed :verified:<p>Really cool for last day of 2022 - decellularized ECM composition of specific anatomical lung regions in non-disease, COPD, and IPF human lungs. Kudos Drs Hoffman, Weiss &amp; team <br /><a href="https://med-mastodon.com/tags/CureCOPD" class="mention hashtag" rel="tag">#<span>CureCOPD</span></a> <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/ECMRules" class="mention hashtag" rel="tag">#<span>ECMRules</span></a> <a href="https://www.sciencedirect.com/science/article/abs/pii/S0142961222006007" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">sciencedirect.com/science/arti</span><span class="invisible">cle/abs/pii/S0142961222006007</span></a></p>
Will Oldham<p>Working on a talk and thought I&#39;d try to visualize the global burden of <a href="https://med-mastodon.com/tags/pulmonaryfibrosis" class="mention hashtag" rel="tag">#<span>pulmonaryfibrosis</span></a>. The closest data set I found was for interstitial lung disease and sarcoidosis. Interesting variability in disease burden around the globe. More work to be done to <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a>. </p><p>This was my first <a href="https://med-mastodon.com/tags/rspatial" class="mention hashtag" rel="tag">#<span>rspatial</span></a> effort in <a href="https://med-mastodon.com/tags/rstats" class="mention hashtag" rel="tag">#<span>rstats</span></a> and it was a strong reminder early R days of just typing in every R command I found on Google until I got what I wanted. Definitely more to learn here!</p>
KaminskiMed :verified:<p>The tip of the iceberg? A case series suggesting oropharyngeal swallowing physiology may be abnormal in some Idiopathic Pulmonary Fibrosis patients. <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/Aspiration" class="mention hashtag" rel="tag">#<span>Aspiration</span></a> <br /><a href="https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-02232-3" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">bmcpulmmed.biomedcentral.com/a</span><span class="invisible">rticles/10.1186/s12890-022-02232-3</span></a></p>
KaminskiMed :verified:<p><span class="h-card" translate="no"><a href="https://med-mastodon.com/@Roberttighe" class="u-url mention">@<span>Roberttighe</span></a></span> hashtags more important on this clanky echo chamber than on <a href="https://med-mastodon.com/tags/MedTwitter" class="mention hashtag" rel="tag">#<span>MedTwitter</span></a> , make sure to follow <a href="https://med-mastodon.com/tags/CurePF" class="mention hashtag" rel="tag">#<span>CurePF</span></a> or <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> <a href="https://med-mastodon.com/tags/PCCMEats" class="mention hashtag" rel="tag">#<span>PCCMEats</span></a> <a href="https://med-mastodon.com/tags/CleanAir" class="mention hashtag" rel="tag">#<span>CleanAir</span></a> maybe introduce others</p>
KaminskiMed :verified:<p><a href="https://med-mastodon.com/tags/AcademicBliss" class="mention hashtag" rel="tag">#<span>AcademicBliss</span></a> is when the bright undergrad from your lab many years ago is now a CEO and scientific founder of a funded company. And what an exciting company! So proud of Dr. Hanadie <a href="https://med-mastodon.com/tags/TheBest" class="mention hashtag" rel="tag">#<span>TheBest</span></a> Yousef!! and now time to rejoin (or maybe lead) the <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a> team<br /><a href="https://juvenatherapeutics.com" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="">juvenatherapeutics.com</span><span class="invisible"></span></a></p>
KaminskiMed :verified:<p>you wondered why I sat in my hotel room l wearing a tie at 9AM - it was to participate in the 2nd European Pulmonary Fibrosis Patient Summit (<a href="https://med-mastodon.com/tags/PFPatientSummit" class="mention hashtag" rel="tag">#<span>PFPatientSummit</span></a>), give the closing keynote about <a href="https://med-mastodon.com/tags/CureIPF" class="mention hashtag" rel="tag">#<span>CureIPF</span></a>!<br />Nothing more humbling and inspiring than giving a talk to patients, family members, advocates. </p><p>And to Early Career - note my Hotel Room two monitor setup - part of the <a href="https://med-mastodon.com/tags/AcademicNomad" class="mention hashtag" rel="tag">#<span>AcademicNomad</span></a> tool box</p>
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