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Giuseppe MichieliA <a href="https://mstdn.science/tags/vaccine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vaccine</a> <a href="https://mstdn.science/tags/platform" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#platform</a> targeting <a href="https://mstdn.science/tags/lung" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lung</a>-resident memory <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a>+ T-cells provides <a href="https://mstdn.science/tags/protection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#protection</a> against heterosubtypic <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> infections in mice and <a href="https://mstdn.science/tags/ferrets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ferrets</a>Source: Nature Communications, AbstractLung tissue-resident memory T (TRM) cells induced by influenza vaccination are crucial for heterosubtypic immunity upon re-exposure to the influenza virus, enabling rapid and robust responses upon reactivation. To enhance the efficacy of influenza vaccines, we induce the…<a href="https://etidioh.wordpress.com/2024/11/29/a-vaccine-platform-targeting-lung-resident-memory-cd4-t-cells-provides-protection-against-heterosubtypic-influenza-infections-in-mice-and-ferrets/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://etidioh.wordpress.com/2024/11/29/a-vaccine-platform-targeting-lung-resident-memory-cd4-t-cells-provides-protection-against-heterosubtypic-influenza-infections-in-mice-and-ferrets/</a>

Sue CohenTo all <a href="https://mstdn.social/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> Voters Do follow @trisha4CO <a href="https://x.com/trisha4colorado/status/1831090832637854132" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://x.com/trisha4colorado/status/1831090832637854132</a> <a href="https://mstdn.social/tags/VoteBlue2024" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VoteBlue2024</a> <a href="https://mstdn.social/tags/VoteOutAllGOP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VoteOutAllGOP</a> <a href="https://mstdn.social/tags/FlipTheHouseBlue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#FlipTheHouseBlue</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nasal</a> <a href="https://mstdn.science/tags/tissue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tissue</a>-resident <a href="https://mstdn.science/tags/memory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#memory</a> <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a>+ T cells persist after <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> A virus <a href="https://mstdn.science/tags/infection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#infection</a> and provide heterosubtypic <a href="https://mstdn.science/tags/protection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#protection</a>, BioRxIV, <a href="https://www.biorxiv.org/content/10.1101/2024.07.06.602325v1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2024.07.06.602325v1</a> Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the nasal tissue (NT) compartment and play a prime role in local viral clearance.

Paul Sochacki, MS<a href="https://mastodon.social/@MaiKueper" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@MaiKueper</a> lymphocyte subset panel will give some idea of what's going on with T-cells and <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> vs <a href="https://mstdn.science/tags/CD8" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD8</a> ratios. I'm not entirely sure the indications (Hx of post-Covid frequent illness? opportunistic infections?) or whether it matters for anything beyond insurance/billing purposes. In most cases you'd still need a clinician to order the lab. Historically this is a flow cytometry test, not every facility has the equipment to run it, and it's frequently referred out.

Jason ON<a href="https://mstdn.social/@knittingknots2" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@knittingknots2</a>I spend a lot of time in <a href="https://masto.ai/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a>. The Dems have an uphill battle, but yeah, this was a poor decision by Boebert won't help Republicans.However, one of the Dem challengers isn't any better than Boebert:<a href="https://coloradonewsline.com/2024/01/08/family-conflict-colorado-ike-mccorkle/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://coloradonewsline.com/2024/01/08/family-conflict-colorado-ike-mccorkle/</a>

Ron BeavisName the type of leukocyte most likely to be CD4+ and at least 5 other types of leukocyte that may also be CD4+.<a href="https://mastodon.social/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> (cluster of differentiation 4): Human Protein Atlas mRNA cell type distributions & GPMDB protein tissue tabbulations. <a href="https://mastodon.social/tags/proteomics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#proteomics</a>

Zoomers of the Sunshine CoastSARS-CoV-2 uses CD4 to infect T-helper lymphocytesMany people with Long Covid are experiencing lymphocytopenia years after acute infection. SARS-CoV-2 infection of T-helper cells is implicated and found to be mediated by CD4. It identifies the interaction between spike RBD domain and N Terminal domain of CD4 molecule as the specific viral attachment strategy.<a href="https://twitter.com/amymitchellart/status/1688713862831329280?s=20" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://twitter.com/amymitchellart/status/1688713862831329280?s=20</a><a href="https://mstdn.ca/tags/TCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TCells</a> <a href="https://mstdn.ca/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> <a href="https://mstdn.ca/tags/CD8" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD8</a> <a href="https://mstdn.ca/tags/Viruses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Viruses</a> <a href="https://mstdn.ca/tags/NTermialDomain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NTermialDomain</a> <a href="https://mstdn.ca/tags/infection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#infection</a> <a href="https://mstdn.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> <a href="https://mstdn.ca/tags/longCOVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#longCOVID</a> <a href="https://mstdn.ca/tags/AIDS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AIDS</a> <a href="https://elifesciences.org/articles/84790" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://elifesciences.org/articles/84790</a>

Giuseppe MichieliStrong <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> T-Cell Responses to Ancestral and <a href="https://mstdn.science/tags/Variant" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Variant</a> Spike Proteins Are Established by NVX-CoV2373 SARS-CoV-2 Primary Vaccination <a href="https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad163/7175115?rss=1" rel="nofollow noopener noreferrer" target="_blank">https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad163/7175115?rss=1</a>

GailWaldby@bsky.socialPhone bank for @JennMcClellanVA at Center for Common Ground’s events, “National Guided Phone Bank: Virginia CD4 Special Election” – sign up now! <a href="https://mastodon.social/tags/cfcg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cfcg</a> <a href="https://mastodon.social/tags/DemCastVA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DemCastVA</a> <a href="https://mastodon.social/tags/Virginia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Virginia</a> <a href="https://mastodon.social/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> <a href="https://www.mobilize.us/cfcg-rov/event/546686/?rname=Gail&share_context=event_details&share_medium=twitter" rel="nofollow noopener noreferrer" target="_blank">https://www.mobilize.us/cfcg-rov/event/546686/?rname=Gail&share_context=event_details&share_medium=twitter</a>

Carolyn KingRT Paul Ogongo Our latest work show <a href="https://mstdn.science/tags/IL17" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IL17</a> <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> <a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a> are preserved in HIV-ART. We identify two subsets of <a href="https://mstdn.science/tags/Th17" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Th17</a> cells; 1 specifically enriched for IL17 production to <a href="https://mstdn.science/tags/Mtb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mtb</a> but not CMV or SEB; and link between IDO-1 activity and circulating Th17 cells.@AnthonyVanTran @UCSF_EXPM @UCSF_GIVI_CFARM. tuberculosis antigen-responsive IL17+ CD4 T cells are disproportionately spared in ART-suppressed HIV biorxiv.org/cgi/content/sh… <a href="https://mstdn.science/tags/biorxiv_immuno" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biorxiv_immuno</a>

GailWaldby@bsky.socialPhone bank for Jennifer McClellan in the Primary for Special Election for Virginia CD4 US House Seat, “Team McClellan Get Out the Vote! Virtual Phone Bank” – sign up now! <a href="https://mastodon.social/tags/DemCastVA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DemCastVA</a> @JennMcClellanVA <a href="https://mastodon.social/tags/USHouse" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#USHouse</a> Virginia <a href="https://mastodon.social/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> <a href="https://mastodon.social/tags/VirginiaDemocrats" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VirginiaDemocrats</a> <a href="https://mastodon.social/tags/VirginiaDems" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VirginiaDems</a> <a href="https://mastodon.social/tags/SpecialElection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SpecialElection</a> <a href="https://www.mobilize.us/mobilize/event/545937/" rel="nofollow noopener noreferrer" target="_blank">https://www.mobilize.us/mobilize/event/545937/</a>

Carolyn Kingtho always weird to give a seminar to myself, it's done! have a listen here if you like: <a href="https://youtu.be/i0GAhB3a2F8" rel="nofollow noopener noreferrer" target="_blank">https://youtu.be/i0GAhB3a2F8</a> the 2nd half is *unpublished* data on <a href="https://mstdn.science/tags/tissue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tissue</a> <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD4</a> <a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a> during <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> and how they fit into a network of <a href="https://mstdn.science/tags/CD8" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CD8</a> <a href="https://mstdn.science/tags/Bcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bcells</a>, <a href="https://mstdn.science/tags/IgA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IgA</a> & <a href="https://mstdn.science/tags/NKcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NKcells</a>. I've received feedback from someone working on tumors that some of it brings new perspective on his data. In return I learned some new stuff about bladder cancer. This open exchange of ideas is why I'm a scientist.

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