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#CCR23

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Todd Fraser :verified:<p>Missed the results of the PATCH trial at <a href="https://med-mastodon.com/tags/CCR23" class="mention hashtag" rel="tag">#<span>CCR23</span></a>?</p><p>Get a free in-depth review here : </p><p><a href="https://osler.app.link/LXHMn1xahCb" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="">osler.app.link/LXHMn1xahCb</span><span class="invisible"></span></a></p><p><a href="https://med-mastodon.com/tags/trauma" class="mention hashtag" rel="tag">#<span>trauma</span></a> <a href="https://med-mastodon.com/tags/FOAMed" class="mention hashtag" rel="tag">#<span>FOAMed</span></a> <a href="https://med-mastodon.com/tags/FOAMcc" class="mention hashtag" rel="tag">#<span>FOAMcc</span></a> <a href="https://med-mastodon.com/tags/medtwitter" class="mention hashtag" rel="tag">#<span>medtwitter</span></a> <a href="https://med-mastodon.com/tags/emergencymedicine" class="mention hashtag" rel="tag">#<span>emergencymedicine</span></a> <a href="https://med-mastodon.com/tags/emergencyphysician" class="mention hashtag" rel="tag">#<span>emergencyphysician</span></a> <a href="https://med-mastodon.com/tags/ER" class="mention hashtag" rel="tag">#<span>ER</span></a> <a href="https://med-mastodon.com/tags/FOAMems" class="mention hashtag" rel="tag">#<span>FOAMems</span></a> <a href="https://med-mastodon.com/tags/FOAMresus" class="mention hashtag" rel="tag">#<span>FOAMresus</span></a> <a href="https://med-mastodon.com/tags/medmastodon" class="mention hashtag" rel="tag">#<span>medmastodon</span></a></p>
Todd Fraser :verified:<p>Great new podcast just released on Osler</p><p>Glenn Eastwood : the TAME trial</p><p><a href="https://osler.app.link/afiJhNlOuBb" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="">osler.app.link/afiJhNlOuBb</span><span class="invisible"></span></a></p><p><a href="https://med-mastodon.com/tags/medtwitter" class="mention hashtag" rel="tag">#<span>medtwitter</span></a> <a href="https://med-mastodon.com/tags/FOAMed" class="mention hashtag" rel="tag">#<span>FOAMed</span></a> <a href="https://med-mastodon.com/tags/FOAMcc" class="mention hashtag" rel="tag">#<span>FOAMcc</span></a> <a href="https://med-mastodon.com/tags/FOAMems" class="mention hashtag" rel="tag">#<span>FOAMems</span></a> <a href="https://med-mastodon.com/tags/FOAMresus" class="mention hashtag" rel="tag">#<span>FOAMresus</span></a> <a href="https://med-mastodon.com/tags/ICU" class="mention hashtag" rel="tag">#<span>ICU</span></a> <a href="https://med-mastodon.com/tags/intensivecare" class="mention hashtag" rel="tag">#<span>intensivecare</span></a> <a href="https://med-mastodon.com/tags/intensivist" class="mention hashtag" rel="tag">#<span>intensivist</span></a> <a href="https://med-mastodon.com/tags/emergencymedicine" class="mention hashtag" rel="tag">#<span>emergencymedicine</span></a> <a href="https://med-mastodon.com/tags/resuscitation" class="mention hashtag" rel="tag">#<span>resuscitation</span></a> <a href="https://med-mastodon.com/tags/OOHCA" class="mention hashtag" rel="tag">#<span>OOHCA</span></a> <a href="https://med-mastodon.com/tags/cardiacarrest" class="mention hashtag" rel="tag">#<span>cardiacarrest</span></a> <a href="https://med-mastodon.com/tags/CCR23" class="mention hashtag" rel="tag">#<span>CCR23</span></a> <a href="https://med-mastodon.com/tags/medmastodon" class="mention hashtag" rel="tag">#<span>medmastodon</span></a></p>
Kenneth Baillie<p><a href="https://critcare.social/tags/Ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Ccr23</span></a> <a href="https://critcare.social/tags/Device" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Device</span></a> trial presented just now. Stopped early for emphatic efficacy on primary endpoint: videolaryngoscopy halved the rate of failed intubation at first attempt compared with direct laryngoscopy. </p><p>Interestingly, although underpowered to detect a difference due to lower event rates, there was no difference in complications</p>
Kenneth Baillie<p>The discussion panel at <a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a> raised the criticism that there were two primary endpoints but no correction for multiple comparisons. I had the chance to discuss this with David Harrison and he explained that there was one clinical primary endpoint, but there is an additional cost effectiveness endpoint that requires 12-month follow up data, so they can’t report yet</p>
Kenneth Baillie<p>OXY-PICU trial randomised critically ill children to restrictive vs liberal SpO2 target (88-92 vs &gt;94). Marginally significant result showing better composite outcome (days alive w/out organ support) with *restrictive* oxygen target. </p><p><a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a></p>
Mathieu Desgroseilliers<p>A great discussions happening here on the Patch trial</p><p><a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a></p><p><a href="https://critcare.social/@kennethbaillie/110542174304354696" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">critcare.social/@kennethbailli</span><span class="invisible">e/110542174304354696</span></a></p>
Kenneth Baillie<p>Next trip revealed at <a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a>. Fascinating result from PATCH trial of tranexamic acid in prehospital trauma patients at high risk of coagulopathy. Mortality reduced, but perfectly balanced by an increase in severe disability. Which group would you rather be in?</p><p><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2215457?query=featured_home" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/NEJM</span><span class="invisible">oa2215457?query=featured_home</span></a></p>
Kenneth Baillie<p><a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a> I’ve followed <a href="https://critcare.social/tags/ukreboatrial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ukreboatrial</span></a> with a little bit of awe since I first heard about it many years ago. There’s something heroic about the effort to do a trial in the context of major haemorrhage. Across the whole UK, clinicians allocated patients at random to receive an intervention to stop bleeding. The entire specialty agreed to apply the scientific method to find the truth.</p>
Kenneth Baillie<p>First result at <a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a> - as convincing a result as could be expected from such a small number of patients (but a huge trial in terms of complexity and ambition): REBOA probably increases mortality, particularly from haemorrhage, particularly early. Jan Jansen presenting - congratulations to him on an important contribution to the evidence</p>
Segun Olusanya<p><a href="https://critcare.social/tags/ccr23" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ccr23</span></a> is on today </p><p>And it’s being live streamed for FREE. Excellent <a href="https://critcare.social/tags/foamed" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>foamed</span></a> <a href="https://critcare.social/tags/foamcc" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>foamcc</span></a></p><p><a href="https://criticalcarereviews.com/" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">criticalcarereviews.com/</span><span class="invisible"></span></a></p><p>Who’s watching? <span class="h-card"><a href="https://critcare.social/@kennethbaillie" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>kennethbaillie</span></a></span></p>