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#brainstimulation

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I was a bit dubious about this study in the Guardian theguardian.com/science/articl, and now it's led me down a rabbit hole finding loads of papers that misused G*power and are consequently badly underpowered .
And the original 'brain stimulation eases hearbreak" paper is looking v problematic.
pubpeer.com/publications/97F44
#statistics #brainstimulation #PubPeer

The Guardian · Electrical brain stimulation can ease heartbreak, study findsBy Caroline Davies

New preprint! We observed a nonlinear relationship between pupil dilation and the intensity of transcutaneous auricular #vagus nerve stimulation (#taVNS) in adult humans. We discuss the potential role of stimulation parameterization in using #pupillometry as biomarker of taVNS’s neuromodulatory effects.

#tVNS #neuromodulation #brainstimulation #gamms

biorxiv.org/content/10.1101/20

bioRxiv · 300 Hz transcutaneous auricular vagus nerve stimulation (taVNS) impacts pupil size nonlinearly as a function of intensityTranscutaneous auricular vagus nerve stimulation (taVNS) is a neuromodulatory technique that may have numerous potential health and human performance benefits. However, optimal stimulation parameters for maximizing taVNS efficacy are unknown. Progress is impeded by disagreement on the identification of a biomarker that reliably indexes activation of neuromodulatory systems targeted by taVNS, including the locus coeruleus-norepinephrine (LC-NE) system. Pupil size varies with LC-NE activity and is one potential taVNS biomarker that has shown inconsistent sensitivity to taVNS in prior studies. The present study examined the relationship between pupil size and taVNS using stimulation parameters that have shown promising behavioral effects in prior studies but have received comparatively little attention. Participants received 30-second trains of 50 μs taVNS pulses delivered below perceptual threshold at 300 Hz to the left external acoustic meatus (EAM) while pupil size was recorded during a pupillary light reflex task. Analysis of pupil size using generalized additive mixed modelling (GAMM) revealed a nonlinear relationship between taVNS intensity and pupil diameter. Active taVNS increased pupil size during stimulation for participants who received taVNS between 2 and approximately 4.8 mA, but not for participants who received higher intensity taVNS (up to 8.1 mA). In addition, taVNS effects persisted in subsequent blocks, mitigating decreases in pupil size over the course of the task. These findings suggest 300 Hz taVNS activates the LC-NE system when applied to the EAM, but its effects may be counteracted at higher intensities. ### Competing Interest Statement The authors have declared no competing interest.

Advances in neurosurgical treatments like focused ultrasound and deep brain stimulation are moving the field towards more personalized care for Parkinson's disease. To learn more, tune in to my conversation with Dr. Doris Wang in this new podcast episode in partnership with The Michael J. Fox Foundation for Parkinson's Research!

michaeljfox.org/podcast/episod

Acacia Clinics is recruiting research participants with anxiety who can come to their site in Sunnyvale, CA.

Acacia is renowned for their works in noninvasive brain stimulation for mental health.

This study is designed to study whether low-intensity ultrasound can temporarily alter self-reported anxiety and brain activity related to emotional processing.
acaciaclinics.com/tus-anxiety-

Acacia ClinicsJoin a Research Study on Anxiety Relief using Transcranial Focused Ultrasound — Acacia ClinicsAnxiety is the most common mental illness in the world, affecting an estimated 40 million people in the United States each year. This study is designed to study whether low-intensity ultrasound can temporarily alter self-reported anxiety and brain activity related to emotional processing.

Hi everyone! I'm very happy to post our new paper we just got published in the Journal of Physiology:

"Scale-invariant Changes in Corticospinal Excitability Reflect Multiplexed Oscillations in the Motor Output"

(Open access here: tinyurl.com/yka2w7hb )

Authors are @marco_emanuele , me, Giacomo Koch, Luciano Fadiga and Alice Tomassini

It took quite some time and effort to get it nice and polished, and now I'm so proud of it!
Marco and Alice did an amazing job!

#Neuroscience #BrainStimulation #sensorimotor #neurophysiology
@IIT_UniFe

19th Annual Mood Disorders Education Day
Saturday, October 14, 2023
9:00 AM – 1:00 PM (PT)
Translating Emerging Treatments for Mood Disorders Into Practice

Please join the Stanford University Mood Disorders Center for exciting presentations on , , , and personalized treatment of mood disorders. Pre-registration is free, but is required to attend the event. Space is limited, so register early!

New paper out in Science Translational Medicine by MRRI Director Dr. Dylan Edwards and colleagues from Burke Neurological Institute and Weill Cornell Medicine. Learn more about how HF-rTMS can lead to axon sprouting and regeneration after spinal cord injury in mice:

mrri.org/new-studies-advance-t