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#bonemarrow

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Public
Regenerative Medicine

Is Muscular Dystrophy no longer incurable?

VIDEO LINK: youtu.be/wBau1quf-50

✨ New Cellular Therapy is giving new life to children aged 3-5 years!

✅ Relief in Duchenne Muscular Dystrophy
✅ Improvement in Hip Muscle weakness
✅ Breakthrough with Bone Marrow Cellular Transplant

🎯 Treatment now available in India, under the expert care of Dr. B. S. Rajput!

📍 Delhi / Mumbai
📞 +91-9820850187 | +91-9820800187
🌐 drrajputorthocentre.com

youtu.be- YouTubeEnjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
#CellularTherapy#DrBSRajput#BoneMarrow
Public
Ron Piggott

New #Video "2025-01-31 - An Update On My Health And Health Care Treatment" This is a long overdue update on my health, health care treatment and the next step. I've been slow to post content during the past few weeks because of the physical pain I am experiencing and the need for rest. Thank you for having patience with me. youtu.be/lBTvIL4O8TU?si=48db_M #artificialhip #setback #bonemarrow

YouTube2025-01-31 - An Update On My Health And Health Care TreatmentBy Ron Piggott
Public
Victoria Stuart 🇨🇦 🏳️‍⚧️

Bone marrow donor/transplant story
Pilot raced thru airport to surprise old friend: woman who saved his life
cnn.com/2024/12/21/travel/unit
news.ycombinator.com/item?id=4

* United Airlines Capt. w. acute myeloid leukemia
* rare, fast-growing blood/bone marrow cancer
* orig. f. abnormal blood stem cells
* donor had opted into bone marrow registry
* donors/patients matched based on human leukocyte antigens
* simple donation process: donate blood

CNN · A pilot raced through the airport to surprise an old friend: the woman who saved his lifeBy Dalia Faheid
#BoneMarrow#OrganDonor#cancer
Public
Arjan Boltjes

"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"

link.springer.com/article/10.1

Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.

SpringerLinkSingle-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma - Frontiers of MedicineNeuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes. However, the molecular mechanisms triggering NB metastasis remain largely uncharacterized. In this study, we generated a transcriptomic atlas of 15 447 NB cells from eight NB samples, including paired samples of primary tumors and bone marrow metastases. We used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common ‘starter’ subpopulation that initiates tumor development and metastasis. The ‘starter’ population exhibited high expression levels of multiple cell cycle-related genes, indicating the important role of cell cycle upregulation in NB tumor progression. In addition, our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition (p-EMT) along the metastatic route from the primary site to the bone marrow. Our study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.
#scRNAseq#tumour#Neuroblastoma
Public
Lukas VFN 🇪🇺

This is seriously cool! With all the fake tech hype all around, let's not forget there is real amazing progress happening.

#FDA Approves First #CRISPR Gene Editing Treatment for #SickleCellDisease

scientificamerican.com/article

"physicians remove a person’s own bone marrow #StemCells, edit them, destroy the untreated #BoneMarrow and then reinfuse the edited cells... Cas9 deactivates BCL11A in stem cells and they begin producing the fetal #hemoglobin and creating #RedBloodCells with a normal shape"

Electron microscopy picture of a misshapen red blood cell
Public
Giuseppe Michieli

#Depletion of #BoneMarrow Hematopoietic Cells in #Ebola Virus-Infected Rhesus #Macaques: A Possible Cause of #Hematologic Abnormalities in Ebola Virus Disease ajp.amjpathol.org/article/S000

The American Journal of PathologyDepletion of Bone Marrow Hematopoietic Cells in Ebola Virus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebola Virus DiseaseThe pathophysiology of long-recognized hematological abnormalities in Ebola virus disease (EVD) is unknown. From limited human sampling (of peripheral blood), it has been postulated that emergency hematopoiesis plays a role in severe EVD, but the systematic characterization of the bone marrow (BM) has not occurred in human disease or in nonhuman primate models. In a lethal rhesus macaque (RhM) model of EVD, sternal BMs from eighteen RhMs were characterized after intramuscular exposure to Ebola virus (EBOV) Kikwit as compared to uninfected controls (n=3).
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