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#Bcells

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Public
Arjan Boltjes

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

insight.jci.org/articles/view/

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

insight.jci.org JCI Insight - Selective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE
#scRNAseq#TCR#carTcells
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Lorraine

The great thing about high profile moron “experts” making blithe uninformed comments such as “Covid doesn’t really damage the immune system” is it angers people who ACTUALLY know & they come at them with #CovidPapers #Jha

This will be my continuing🧵on anything related to the destruction of #tcells #bcells #ImmuneDysregulation in an attempt to be organized if only for myself🖤

Published January 14, 2022
bmcmedicine.biomedcentral.com/

In truth just skimmed but my grasp on this in January 2024 is something that would have been impossible for me to understand in 2022 while experiencing my #sarscov2 2nd infection b/c my level of biology was zero & my lack of understanding led me to believe #hybridImmunity would give me 2 years at least. Mind you I never took my mask off except w/my MIL🦃🎄2021

Philip Dettmer “immune” book along w/the incredibly intelligent🧠🧠🧠here🐘&🐦have been invaluable in at least allowing me to read & generally follow along

Basically this study tells me, stay down for 6 months minimum

BioMed CentralLong-term perturbation of the peripheral immune system months after SARS-CoV-2 infection - BMC MedicineBackground Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID-19) pandemic. It is increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms for many months after infection, a condition referred to as “long COVID”, post-acute sequelae of COVID-19 (PASC), post-acute COVID-19 syndrome, or post COVID-19 condition. However, despite the plethora of research on COVID-19, relatively little is known about the molecular underpinnings of these long-term effects. Methods We have undertaken an integrated analysis of immune responses in blood at a transcriptional, cellular, and serological level at 12, 16, and 24 weeks post-infection (wpi) in 69 patients recovering from mild, moderate, severe, or critical COVID-19 in comparison to healthy uninfected controls. Twenty-one of these patients were referred to a long COVID clinic and > 50% reported ongoing symptoms more than 6 months post-infection. Results Anti-Spike and anti-RBD IgG responses were largely stable up to 24 wpi and correlated with disease severity. Deep immunophenotyping revealed significant differences in multiple innate (NK cells, LD neutrophils, CXCR3+ monocytes) and adaptive immune populations (T helper, T follicular helper, and regulatory T cells) in convalescent individuals compared to healthy controls, which were most strongly evident at 12 and 16 wpi. RNA sequencing revealed significant perturbations to gene expression in COVID-19 convalescents until at least 6 months post-infection. We also uncovered significant differences in the transcriptome at 24 wpi of convalescents who were referred to a long COVID clinic compared to those who were not. Conclusions Variation in the rate of recovery from infection at a cellular and transcriptional level may explain the persistence of symptoms associated with long COVID in some individuals.
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Public
Lorraine

@EeyoreTheCat @BlackAzizAnansi
HA!
HAAAAAAAAAAAAA!

This 2024 variant is equally as bad as 2022 & 2020 I can confidently report from the trenches☹️

Just b/c people have a broken #immuneSystem #ImmuneDysregulation #tCells #bCells from #constantCovid & aren’t displaying reactive symptoms indicative of a healthy immune system, the non-response “just a cold” isn’t the flex they think it is

science.org/doi/10.1126/sciadv

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Lorraine

@thepoliticalcat
#eatOutToHelpOut
Psychopaths are in power
The way I personally differentiate between garden variety sociopaths & psychopaths is the willingness to kill w/disregard

They fear what happened to the economy in 2020-2021 will happen again

Short term gains is all anyone cares about

Psychopaths are really insecure yet they possess an amount of #hubris that’s other worldly & believe they are special & will somehow be unscathed. I was “blessed”(🙄) w/an insane family to observe, not formally educated in it

This article is obvi meant to placate fears of getting repeatedly sick & preys on people’s ignorance of immune system

I fell for vague articles like this early on talking abstractedly about #Bcells #Tcells etc

These charlatans are #gaslighting people to their deaths. The🚑🚒🚨🚨🚨#nyc have been constant again & expect it will maintain this level until spring

Public
Benjamin Carr, Ph.D. 👨🏻‍💻🧬

A blood test for long #Covid is possible, new research suggests
The research is among the first to prove that "#LongCovid is, in fact, a biological illness," said David Putrino, principal investigator of the new study and a professor at the Icahn School of Medicine at Mount Sinai in New York. The activity of #immune system cells called #Tcells and #Bcells — which help fight off #germs — was "irregular" in long Covid patients, Putrino said.
nbcnews.com/health/health-news

Public
Phys.org

Referenced link: medicalxpress.com/news/2023-06
Discuss on discu.eu/q/https://medicalxpre

Originally posted by Phys.org / @physorg_com: nitter.platypush.tech/medical_

RT by @physorg_com: Macrophages that rapidly digest dying #Bcells may point to future autoimmune disorder treatments @JExpMed rupress.org/jem/article/220/4/ medicalxpress.com/news/2023-06

medicalxpress.comMacrophages that rapidly digest dying B cells may point to future autoimmune disorder treatmentsParents tell their children to eat all the food on their plate, down to the last crumb. Certain cells within our lymph nodes, like obedient children, diligently follow this instruction. Although these cells—a subtype of macrophages, or "big eaters"—were first described in 1884 by German biologist Walther Flemming, their origin and mode of operation had until now remained a mystery.
Public
Monika Wolkers

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

biorxiv.org/content/10.1101/20

bioRxivCD5L is a canonical component of circulatory IgMImmunoglobulin M (IgM) is an evolutionary conserved key component of humoral immunity, and the first antibody isotype to emerge during an immune response. IgM is a large (1 MDa), multimeric protein, for which both hexameric and pentameric structures have been described, the latter additionally containing a joining (J) chain. Using a combination of single-particle mass spectrometry and mass photometry, proteomics and immunochemical assays, we here demonstrate that circulatory (serum) IgM exclusively exists as a complex of J-chain-containing pentamers covalently bound to the small CD5 antigen-like (CD5L, 36 kDa) protein. In sharp contrast, secretory IgM in saliva and milk is principally devoid of CD5L. Unlike IgM itself, CD5L is not produced by B cells, implying that it associates with IgM in the extracellular space. We demonstrate that CD5L integration has functional implications, i.e., it diminishes IgM binding to two of its receptors, the FcαμR and the polymeric Immunoglobulin receptor (pIgR). On the other hand, binding to FcμR as well as complement activation via C1q seem unaffected by CD5L integration. Taken together, we redefine the composition of circulatory IgM as a J-chain containing pentamer, always in complex with CD5L. ### Competing Interest Statement The authors have declared no competing interest.
#immunology#Bcells#textbook
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Chuck Darwin

A particular focus is #lymphoid tissues that produce, store and carry #Tcells that fight infection, and #antibody-making #Bcells.

The coronavirus may also be hiding out in long-lived #nerve cells and #heart muscle, where it may drive chest #pain, brain fog, #fatigue and other long-Covid symptoms, said Diane Griffin, a virologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore who has studied the body’s response to viral infections for more than 50 years.

“We have pretty good information from acute #RNA #virus infections that RNA does persist and that it does have consequences,” said Griffin, who is vice president of the US National Academy of Sciences. “Basically, it’s hard to get rid of viruses.”

Proving that persistent viral #infection causes long Covid will be difficult, Griffin said. Viruses in stealth mode suppress replication to avoid harming their host cells.

Despite extensive distribution of coronavirus RNA throughout patients’ bodies, Chertow’s team saw little evidence of inflammation or that the immune system had tried to destroy infected cells outside the respiratory tract.

(4/n)

bloomberg.com/news/features/20

Bloomberg · Hidden Viruses In Your Body Could Answer Why Long Covid LingersBy Jason Gale
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