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#Bardoxolone

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Swapnil Hiremath :renal: MD<p>Not sure what happens to <a href="https://med-mastodon.com/tags/Bardoxolone" class="mention hashtag" rel="tag">#<span>Bardoxolone</span></a> in <a href="https://med-mastodon.com/tags/Alport" class="mention hashtag" rel="tag">#<span>Alport</span></a> <br /><a href="https://med-mastodon.com/tags/NephJC" class="mention hashtag" rel="tag">#<span>NephJC</span></a> summary: <a href="http://www.nephjc.com/news/bardoxolone" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">http://www.</span><span class="">nephjc.com/news/bardoxolone</span><span class="invisible"></span></a></p><p>FDA rejection <a href="https://www.hcplive.com/view/fda-rejects-bardoxolone-methyl-chronic-kidney-disease" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">hcplive.com/view/fda-rejects-b</span><span class="invisible">ardoxolone-methyl-chronic-kidney-disease</span></a></p><p>6/6</p>
Swapnil Hiremath :renal: MD<p>A downstream effect is that this has lead to a premature halting of the FALCON trial of <a href="https://med-mastodon.com/tags/Bardoxolone" class="mention hashtag" rel="tag">#<span>Bardoxolone</span></a> in <a href="https://med-mastodon.com/tags/ADPKD" class="mention hashtag" rel="tag">#<span>ADPKD</span></a> N = 809 <a href="https://clinicaltrials.gov/ct2/show/NCT03918447" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">clinicaltrials.gov/ct2/show/NC</span><span class="invisible">T03918447</span></a> </p><p>via this <a href="https://pkdcure.org/why-did-the-falcon-clinical-trial-end/" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">pkdcure.org/why-did-the-falcon</span><span class="invisible">-clinical-trial-end/</span></a></p><p>I guess the molecule is mostly dead? </p><p>5/</p>
Swapnil Hiremath :renal: MD<p>Things getting weird with <a href="https://med-mastodon.com/tags/Bardoxolone" class="mention hashtag" rel="tag">#<span>Bardoxolone</span></a> (who would have thunk!)</p><p>Remember bard is the nrf-2 activator and has been reported to *increase* GFR. This molecule bombed with the Ph 3 BEACON trial where it caused *more* HF and MACE <a href="https://www.nejm.org/doi/full/10.1056/nejmoa1306033" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://www.</span><span class="ellipsis">nejm.org/doi/full/10.1056/nejm</span><span class="invisible">oa1306033</span></a><br />1/</p>
Swapnil Hiremath :renal: MD<p>Does <a href="https://med-mastodon.com/tags/Bardoxolone" class="mention hashtag" rel="tag">#<span>Bardoxolone</span></a> do anything in <a href="https://med-mastodon.com/tags/Alport" class="mention hashtag" rel="tag">#<span>Alport</span></a> beyond make the <a href="https://med-mastodon.com/tags/GFR" class="mention hashtag" rel="tag">#<span>GFR</span></a> number go up? </p><p>Read as Jamie Willows and <span class="h-card" translate="no"><a href="https://med-mastodon.com/@Priti899" class="u-url mention">@<span>Priti899</span></a></span> eviscerate the <a href="https://med-mastodon.com/tags/CARDINAL" class="mention hashtag" rel="tag">#<span>CARDINAL</span></a> trial for <a href="https://med-mastodon.com/tags/nephJC" class="mention hashtag" rel="tag">#<span>nephJC</span></a> </p><p><a href="http://www.nephjc.com/news/bardoxolone" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">http://www.</span><span class="">nephjc.com/news/bardoxolone</span><span class="invisible"></span></a></p><p>Discussion this week</p>
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