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#bacteriophage

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PLOS Biology<p>A precursor procapsid is initially formed during <a href="https://fediscience.org/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> assembly, but how? The <a href="https://fediscience.org/tags/cryoEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cryoEM</span></a> structure of the scaffolding protein complex &amp; portal within <a href="https://fediscience.org/tags/phage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>phage</span></a> P22 procapsid reveals how this complex orchestrates the initiation of procapsid assembly <span class="h-card" translate="no"><a href="https://fediscience.org/@PLOSBiology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>PLOSBiology</span></a></span> <a href="https://plos.io/44B71iE" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/44B71iE</span><span class="invisible"></span></a></p>
Preston Maness ☭<p><span class="h-card" translate="no"><a href="https://mas.to/@farbel" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>farbel</span></a></span> <span class="h-card" translate="no"><a href="https://syzito.xyz/@Black_Flag" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>Black_Flag</span></a></span> A medical example: Phage therapy, pioneered in the USSR.</p><p><a href="https://en.wikipedia.org/wiki/Phage_therapy" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">en.wikipedia.org/wiki/Phage_th</span><span class="invisible">erapy</span></a></p><p><a href="https://tenforward.social/tags/socialism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>socialism</span></a> <a href="https://tenforward.social/tags/communism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>communism</span></a> <a href="https://tenforward.social/tags/marxism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>marxism</span></a> <a href="https://tenforward.social/tags/capitalism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>capitalism</span></a> <a href="https://tenforward.social/tags/PhageTherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhageTherapy</span></a> <a href="https://tenforward.social/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a></p>
Frank Aylward<p>We have a new preprint describing a method for <a href="https://genomic.social/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> phylogenetics and comparative genomics. </p><p>Maybe useful for those interested in all the amazing <a href="https://genomic.social/tags/phages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>phages</span></a> out there and their bizarre mosaic genomes </p><p>Towards a unifying phylogenomic framework for tailed phages</p><p><a href="https://www.biorxiv.org/content/10.1101/2024.10.21.619452v1.abstract" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.10.21.619452v1.abstract</span></a></p><p><a href="https://genomic.social/tags/viruses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>viruses</span></a> <a href="https://genomic.social/tags/microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiology</span></a></p>
tomsharp<p>1915,1917: Frederick Twort &amp; Félix d’Herelle discovered bacteriophages, virus that prey on bacteria. <a href="https://mastodon.sdf.org/tags/Poetry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Poetry</span></a> <a href="https://mastodon.sdf.org/tags/Science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Science</span></a> <a href="https://mastodon.sdf.org/tags/History" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>History</span></a> <a href="https://mastodon.sdf.org/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Virology</span></a> <a href="https://mastodon.sdf.org/tags/Bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bacteriophage</span></a> <a href="https://mastodon.sdf.org/tags/Twort" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Twort</span></a> <a href="https://mastodon.sdf.org/tags/d" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>d</span></a>’Herelle (<a href="https://sharpgiving.com/thebookofscience/items/p1915b.html" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">sharpgiving.com/thebookofscien</span><span class="invisible">ce/items/p1915b.html</span></a>)</p>
Maurice Lanselle<p>Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [4 / 4]</p><p>. .. Once they have the right phage or series of phages, and FDA approval is obtained, the phage is used and can be delivered through inhalation, injection, or ingestion.</p><p><a href="https://oc.todon.fr/tags/Yale" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Yale</span></a> <a href="https://oc.todon.fr/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://oc.todon.fr/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> </p><p>Article also discusses</p><p>Reducing the spread of AMR in the hospital</p><p>Pathogens in the pipes</p><p> “Care Signature pathways,” to guide clinical decision making, including decision involving antibiotics.</p>
Maurice Lanselle<p>Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [3 / 4]</p><p>They categorize and store these phages to create a “phage library” of potential candidates for phage therapy. To treat patient infections, a bacterial sample is obtained from patients and tested by the phage library to identify which phages are best suited to kill the bacteria in question. </p><p><a href="https://oc.todon.fr/tags/Yale" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Yale</span></a><br><a href="https://oc.todon.fr/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a><br><a href="https://oc.todon.fr/tags/medecine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medecine</span></a><br><a href="https://oc.todon.fr/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a></p>
Maurice Lanselle<p>Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [3 / 4]</p><p>They categorize and store these phages to create a “phage library” of potential candidates for phage therapy. To treat patient infections, a bacterial sample is obtained from patients and tested by the phage library to identify which phages are best suited to kill the bacteria in question. </p><p><a href="https://oc.todon.fr/tags/Yale" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Yale</span></a> <a href="https://oc.todon.fr/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://oc.todon.fr/tags/medecine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medecine</span></a> <a href="https://oc.todon.fr/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a></p>
Maurice Lanselle<p>Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More [2 / 4]</p><p>This was made possible through the Food and Drug Administration’s (FDA) expanded access pathway, which allows for the use of experimental treatments in life-threatening conditions when no other comparable treatments exist</p><p>Through a process called “phage hunting,” the research team looks for clinically relevant phages both locally and around the world.</p><p><a href="https://oc.todon.fr/tags/medecine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medecine</span></a> <a href="https://oc.todon.fr/tags/Yale" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Yale</span></a> <a href="https://oc.todon.fr/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://oc.todon.fr/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a></p>
Maurice Lanselle<p>Antibiotic Resistance: Fighting a Global Threat With ‘Phage-hunting’ and More<br>October 31, 2024 by Eva Cornman</p><p><a href="https://medicine.yale.edu/news-article/antibiotic-resistance-fighting-a-global-threat-with-phage-hunting-and-more/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">medicine.yale.edu/news-article</span><span class="invisible">/antibiotic-resistance-fighting-a-global-threat-with-phage-hunting-and-more/</span></a></p><p>Led by Paul E. Turner, PhD, Rachel Carson Professor of Ecology and Evolutionary Biology, the Center for Phage Biology and Therapy at Yale has been using bacteriophages (phages for short) to treat infections caused by multidrug-resistant bacteria since 2013. </p><p><a href="https://oc.todon.fr/tags/Yale" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Yale</span></a> <a href="https://oc.todon.fr/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://oc.todon.fr/tags/medecin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medecin</span></a> <a href="https://oc.todon.fr/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> </p><p>[1 / 4]</p>
Peter Riley<p>'dangerous <a href="https://mastodon.social/tags/Merri" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Merri</span></a> lurker' (Merri-merri-uth nyilam marra-natj in <a href="https://mastodon.social/tags/woiwurrung" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>woiwurrung</span></a> might be useful in treating bacterial infections.</p><p><a href="https://mastodon.social/tags/Bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bacteriophage</span></a> <br><a href="https://www.friendsofmerricreek.org.au/bacteriophage" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">friendsofmerricreek.org.au/bac</span><span class="invisible">teriophage</span></a> </p><p><a href="https://mastodon.social/tags/AntiMicrobialResistance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AntiMicrobialResistance</span></a> <br><a href="https://www.monash.edu/impact-amr" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">monash.edu/impact-amr</span><span class="invisible"></span></a></p><p>Bacteriophage Virions <br><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8269216/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pmc.ncbi.nlm.nih.gov/articles/</span><span class="invisible">PMC8269216/</span></a></p><p><a href="https://mastodon.social/tags/firstnations" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>firstnations</span></a> <a href="https://mastodon.social/tags/Wurundjeri" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Wurundjeri</span></a> <br><a href="https://www.wurundjeri.com.au/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">wurundjeri.com.au/</span><span class="invisible"></span></a></p>
Prof Paula Salgado<p>21y after collecting data during my PhD, we got to publish the structure of RNA-dependent RNA polymerase from <a href="https://mastodon.social/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> phi8!<br>Unsolvable in 2003 but <a href="https://mastodon.social/tags/AlphaFold2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AlphaFold2</span></a> model worked!</p><p><a href="https://www.nature.com/articles/s41598-024-75213-7" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41598-024</span><span class="invisible">-75213-7</span></a></p><p>Lesson learned: never discard data!</p><p>Great job Kamel El Omari getting it over the line!</p>
katch wreck<p>i did a Summer internship studying homing introns in college. big advance!</p><p>"This work demonstrates how a homing endonuclease can be deployed in interference competition among viruses and provide a relative fitness advantage. Given the ubiquity of homing endonucleases, this selective advantage likely has widespread evolutionary implications in diverse plasmid and viral competition as well as virus-host interactions."</p><p><a href="https://mastodon.social/tags/homing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>homing</span></a> <a href="https://mastodon.social/tags/endonuclease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>endonuclease</span></a> <a href="https://mastodon.social/tags/phage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>phage</span></a> <a href="https://mastodon.social/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> <a href="https://mastodon.social/tags/virus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>virus</span></a></p><p><a href="https://www.science.org/doi/10.1126/science.adl1356" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/scienc</span><span class="invisible">e.adl1356</span></a></p>
Bruce Hamilton<p>For <a href="https://mastodon.social/tags/ThrowbackThursday" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ThrowbackThursday</span></a> , here is the first complete genome sequence: 5375 bp of Phi-X174. Fred Sanger, et al., 1977.</p><p><a href="https://www.nature.com/articles/265687a0" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">nature.com/articles/265687a0</span><span class="invisible"></span></a></p><p><a href="https://mastodon.social/tags/genomics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>genomics</span></a> <a href="https://mastodon.social/tags/genetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>genetics</span></a> <a href="https://mastodon.social/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a></p>
GrrlScientist ⧖ Ⓥ :verified:<p>Personalized Phage Therapy Heals Cat With Deadly Bacterial Infection, via Hebrew University, published by <a href="https://mstdn.science/tags/Veterinary" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Veterinary</span></a>🩺 Quarterly</p><p>by <span class="h-card" translate="no"><a href="https://mstdn.science/@GrrlScientist" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>GrrlScientist</span></a></span></p><p><a href="https://mstdn.science/tags/Medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Medicine</span></a>⚕️ <a href="https://mstdn.science/tags/PhageTherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhageTherapy</span></a> <a href="https://mstdn.science/tags/Microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Microbiology</span></a>🔬 <a href="https://mstdn.science/tags/MDRO" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MDRO</span></a> <a href="https://mstdn.science/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteria</span></a>🧫 <a href="https://mstdn.science/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a>🦠 <a href="https://mstdn.science/tags/cats" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cats</span></a>🐈‍⬛ <a href="https://mstdn.science/tags/pets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pets</span></a>🐾 <a href="https://mstdn.science/tags/SciComm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SciComm</span></a>🧪 <a href="https://www.forbes.com/sites/grrlscientist/2024/05/30/personalized-phage-therapy-heals-cat-with-deadly-bacterial-infection/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">forbes.com/sites/grrlscientist</span><span class="invisible">/2024/05/30/personalized-phage-therapy-heals-cat-with-deadly-bacterial-infection/</span></a></p>
GrrlScientist ⧖ Ⓥ 🇺🇦<p>Personalized Phage Therapy Heals Cat With Deadly Bacterial Infection, via Hebrew University, published by <a href="https://mastodon.social/tags/Veterinary" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Veterinary</span></a>🩺 Quarterly</p><p>by <span class="h-card" translate="no"><a href="https://mastodon.social/@grrlscientist" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>grrlscientist</span></a></span></p><p><a href="https://mastodon.social/tags/Medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Medicine</span></a>⚕️ <a href="https://mastodon.social/tags/PhageTherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PhageTherapy</span></a> <a href="https://mastodon.social/tags/Microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Microbiology</span></a>🔬 <a href="https://mastodon.social/tags/MDRO" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MDRO</span></a> <a href="https://mastodon.social/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteria</span></a>🧫 <a href="https://mastodon.social/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a>🦠 <a href="https://mastodon.social/tags/cats" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cats</span></a>🐈‍⬛ <a href="https://mastodon.social/tags/pets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pets</span></a>🐾 <a href="https://mastodon.social/tags/SciComm" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SciComm</span></a>🧪 <a href="https://www.forbes.com/sites/grrlscientist/2024/05/30/personalized-phage-therapy-heals-cat-with-deadly-bacterial-infection/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">forbes.com/sites/grrlscientist</span><span class="invisible">/2024/05/30/personalized-phage-therapy-heals-cat-with-deadly-bacterial-infection/</span></a></p>
CellBioNews<p>'Zombie cells' in the sea: <a href="https://scientificnetwork.de/tags/Viruses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Viruses</span></a> keep the most common <a href="https://scientificnetwork.de/tags/marine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>marine</span></a> <a href="https://scientificnetwork.de/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteria</span></a> in check.</p><p><a href="https://scientificnetwork.de/tags/SAR11" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SAR11</span></a> <a href="https://scientificnetwork.de/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> <a href="https://scientificnetwork.de/tags/pelagiphage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pelagiphage</span></a></p><p><a href="https://phys.org/news/2024-05-zombie-cells-sea-viruses-common.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">phys.org/news/2024-05-zombie-c</span><span class="invisible">ells-sea-viruses-common.html</span></a></p>
AskPippa🇨🇦<p>My new story for the Medical Post/Canadian Healthcare Network.<br><a href="https://c.im/tags/Doctors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Doctors</span></a> and <a href="https://c.im/tags/pharmacists" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pharmacists</span></a> in Canada can log on for free. Here are a few paragraphs.</p><p>Could a century old treatment be an answer to antibiotic resistance? <br>In a first in Canada, a patient with an <a href="https://c.im/tags/antibiotic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>antibiotic</span></a> resistant artificial joint infection has received treatment with phage therapy and is showing promising early responses.</p><p>“This is cutting edge stuff, and a potentially new technology,” said Dr. Marisa Azad, the infectious diseases physician who treated the patient. She is also an assistant professor of medicine at the University of Ottawa. </p><p>The patient presented with severe periprosthetic joint infection (PJI) in the summer of 2023. She had already undergone multiple surgeries and had experienced several relapses and infections with the same persistent bacteria.</p><p>“She’d been on multiple very prolonged courses of antibiotics and had a severe drug allergy to two major drug classes of antibiotics. I was extremely limited in what I could use to treat her,” Dr. Azad told the Medical Post in an interview.</p><p>That’s when the idea arose of trying an experimental treatment course with phage therapy. The team got approval for doing the experimental treatment from Health Canada, and worked with Winnipeg-based Cytophage, which supplied the phages.</p><p>“We developed a protocol and gave her therapy over two weeks while she was admitted to hospital. She’s completed her therapy. Now we’re monitoring her closely and giving her adjunctive antibiotics,” she said.</p><p>The idea didn’t come out of the blue. In the medical literature, a study from just last year in Clinical <a href="https://c.im/tags/Infectious" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Infectious</span></a> Diseases provided a review of 33 previously published cases of patients with end-stage, refractory bone and joint infections (BJI) who underwent treatment with phage therapy. The authors found that from those case reports, “29 (87%) achieved microbiological or clinical success, two (5.9%) relapsed with the same organisms, and two (5.9%) with a different organism” with no serious adverse events.</p><p>The conclusions of that paper stated there were “important advantages, disadvantages, and barriers to the implementation of phage therapy for BJIs.” Yet, at the same time, the authors added they, “believe that if phage therapy were to be used earlier in the clinical course, fewer cumulative antibiotics may be needed in an individual treatment course.”</p><p>The word phage is short for <a href="https://c.im/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a>, a word coined in 1917—literally meaning bacteria-eater. They are viruses whose lifecycle depends on certain types of bacteria. </p><p>“They latch on to specific types of bacteria and inject their genetic material into the bacterial cell." Dr. Azad explained. "They take over the bacterial cells’ machinery to produce more little viruses inside and explode or burst open the bacteria,” releasing viral particles that can go and infect other cells of the same type of bacteria.</p><p>Intriguingly, each <a href="https://c.im/tags/phage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>phage</span></a> targets a specific type of <a href="https://c.im/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteria</span></a>... <br>The story of phages started over 100 years ago. They were independently discovered, first in 1915 by a British pathologist, Frederick Twort, and then again in 1917 by French-Canadian microbiologist Felix d’Herelle. And...</p><p><a href="https://c.im/tags/MedMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MedMastodon</span></a> <a href="https://c.im/tags/IDmastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>IDmastodon</span></a> <a href="https://c.im/tags/microbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiology</span></a> <span class="h-card" translate="no"><a href="https://a.gup.pe/u/medmastodon" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>medmastodon</span></a></span> <br><a href="https://www.canadianhealthcarenetwork.ca/could-century-old-treatment-be-answer-antibiotic-resistance" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">canadianhealthcarenetwork.ca/c</span><span class="invisible">ould-century-old-treatment-be-answer-antibiotic-resistance</span></a></p>
b-rain<p><a href="https://troet.cafe/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> <a href="https://troet.cafe/tags/meme" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>meme</span></a> <a href="https://troet.cafe/tags/humor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>humor</span></a></p>
CellBioNews<p>Study suggests <a href="https://scientificnetwork.de/tags/host_response" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>host_response</span></a> needs to be studied along with other <a href="https://scientificnetwork.de/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a> research.</p><p><a href="https://phys.org/news/2024-04-host-response-bacteriophage.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">phys.org/news/2024-04-host-res</span><span class="invisible">ponse-bacteriophage.html</span></a></p>
CellBioNews<p>Researchers reveal dual-function mechanism of <a href="https://scientificnetwork.de/tags/bacteriophage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteriophage</span></a>-derived <a href="https://scientificnetwork.de/tags/protein" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>protein</span></a> <a href="https://scientificnetwork.de/tags/AcrIIA15" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AcrIIA15</span></a>.</p><p><a href="https://scientificnetwork.de/tags/CRISPR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CRISPR</span></a> </p><p><a href="https://phys.org/news/2024-03-reveal-dual-function-mechanism-bacteriophage.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">phys.org/news/2024-03-reveal-d</span><span class="invisible">ual-function-mechanism-bacteriophage.html</span></a></p>