Effect of wild-type #vaccine doses on #BA5 hybrid #immunity, disease #severity, and #XBB #reinfection risk

Source: Journal of Virology, ABSTRACTVaccination against the wild-type (WT) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus did not produce detectable levels of neutralizing antibodies (NAbs) against the BA.5 strain before it emerged. However, coronavirus disease-2019 (COVID-19) severity varied highly between unvaccinated, partially vaccinated,…

https://etidioh.wordpress.com/2024/11/05/effect-of-wild-type-vaccine-doses-on-ba5-hybrid-immunity-disease-severity-and-xbb-reinfection-risk/

(Mirroring old account)

Here's an alteration I made of a FANTASTIC flowchart by "Your Local Epidemiologist" on Substack:

https://yourlocalepidemiologist.substack.com/p/state-of-affairs-oct-12

I amended it with TRG's COVID clan nicknames and added an arm (or whatever it's called) for BA.5.

Impaired neutralizing #antibody #efficacy of #tixagevimab-cilgavimab 150+150 mg as pre-exposure #prophylaxis against #Omicron #BA5. A real-world experience in booster vaccinated immunocompromised patients, J Clin Virol.: https://doi.org/10.1016/j.jcv.2023.105584 #reseach #science #medicine #mAbs #betacoronavirus #sarbecovirus #covid19

“There was a small but significant increase in peak neutralizing antibody responses against #Omicron #BA5 and #XBB15 following the first #bivalent #booster, but no significant increase in peak titers following the second bivalent booster. Omicron-specific #neutralizing titers remained low after both doses of the BA.5 bivalent booster.” https://mstdn.social/@erictopol/110894423101207690

[Articles] Relative #effectiveness of monovalent and bivalent #mRNA #boosters in preventing severe #COVID19 due to #omicron #BA5 infection up to 4 months post-administration in people aged 60 years or older in #Italy: a retrospective matched cohort study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00374-2/fulltext?rss=yes #epidemiology #health #policy #vaccine #vaccination #elderly #medicine #research

Associations of #COVID19 #symptoms with #omicron subvariants #BA2 and #BA5, host status, and #clinical outcomes in #Japan: a registry-based observational study - Lancet ID.: https://doi.org/10.1016/S1473-3099(23)00271-2 #epidemic #pandemic #epidemiology

#mRNA #vaccines and hybrid #immunity use different B cell #germlines against #Omicron #BA4 and #BA5 https://www.nature.com/articles/s41467-023-37422-y

[Articles] Protective #immunity of #SARS-CoV-2 #infection and #vaccines against medically attended symptomatic #omicron #BA4, #BA5, and #XBB #reinfections in #Singapore: a national cohort study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00060-9/fulltext?rss=yes

[Comment] Real-world #effectiveness of #nirmatrelvir–ritonavir against #BA4 and #BA5 #omicron #SARS-CoV-2 #variants https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00056-7/fulltext?rss=yes

[Articles] Real-world use of #nirmatrelvir–ritonavir in #outpatients with #COVID19 during the era of #omicron #variants including #BA4 and #BA5 in #Colorado, #USA: a retrospective cohort study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00011-7/fulltext?rss=yes

Comparative #Effectiveness of #COVID19 #Vaccines in Preventing #Infections and Disease #Progression from #SARS-CoV-2 #Omicron #BA5 and #BA2, #Portugal https://wwwnc.cdc.gov/eid/article/29/3/22-1367_article

#Seroprevalence of Specific #SARS-CoV-2 #Antibodies during #Omicron #BA5 Wave, #Portugal, April–June 2022 https://wwwnc.cdc.gov/eid/article/29/3/22-1546_article

#SARS-CoV-2 #Incubation Period during the #Omicron #BA5–Dominant Period in #Japan https://wwwnc.cdc.gov/eid/article/29/3/22-1360_article

Link-Gelles R, Ciesla AA, Roper LE, et al. Early #Estimates of Bivalent #mRNA #Booster Dose Vaccine #Effectiveness in Preventing Symptomatic #SARS-CoV-2 #Infection Attributable to #Omicron #BA5– and #XBB/XBB.1.5–Related Sublineages Among Immunocompetent Adults — Increasing Community Access to Testing Program, #USA, Dec 22–Jan 23. MMWR Morb Mortal Wkly Rep. ePub: 25 January 2023. DOI: http://dx.doi.org/10.15585/mmwr.mm7205e1.

#Epidemiology of #SARS-CoV-2 #Omicron #BA5 Infections, #Macau, June–July 2022 https://wwwnc.cdc.gov/eid/article/29/2/22-1243_article

#Japan, eight #covid19 wave: ''　　According to the information released by the #Tokyo Metropolitan Welfare and #Health Bureau, starting from the 7th wave of the epidemic, the #omicron variant #BA5 is mainly prevalent in Japan, but it has been gradually replaced by the new mutant strains #BF7 and #BQ11 , #XBB15 replaced, their immune escape ability is stronger, and their transmission ability becomes stronger.'' SINA: https://k.sina.com.cn/article_5044281310_12ca99fde01901xx6l.html?from=news&subch=onews

#Immunogenicity of #BA5 #Bivalent mRNA #Vaccine #Boosters, NEJM: https://www.nejm.org/doi/full/10.1056/NEJMc2213948?query=TOC&cid=NEJM%20eToc,%20January%2012,%202023%20DM1879651_NEJM_Non_Subscriber&bid=1355075840