Nick Mark, MD @nick

Giuseppe Michieli<a href="https://mstdn.science/tags/Lineage" class="mention hashtag" rel="nofollow noopener" target="_blank">#Lineage</a>-specific <a href="https://mstdn.science/tags/pathogenicity" class="mention hashtag" rel="nofollow noopener" target="_blank">#pathogenicity</a>, immune <a href="https://mstdn.science/tags/evasion" class="mention hashtag" rel="nofollow noopener" target="_blank">#evasion</a>, and virological <a href="https://mstdn.science/tags/features" class="mention hashtag" rel="nofollow noopener" target="_blank">#features</a> of <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> / <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> and <a href="https://mstdn.science/tags/EG51" class="mention hashtag" rel="nofollow noopener" target="_blank">#EG51</a> / HK.3Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…<a href="https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/" rel="nofollow noopener" translate="no" target="_blank">https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/</a>

Giuseppe MichieliStructural basis for <a href="https://mstdn.science/tags/receptor" class="mention hashtag" rel="nofollow noopener" target="_blank">#receptor</a>-binding domain mobility of the <a href="https://mstdn.science/tags/spike" class="mention hashtag" rel="nofollow noopener" target="_blank">#spike</a> in <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> and <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a>Source: Nature Communications, AbstractSince 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD in the down-conformation to…<a href="https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/" rel="nofollow noopener" translate="no" target="_blank">https://etidioh.wordpress.com/2024/10/07/structural-basis-for-receptor-binding-domain-mobility-of-the-spike-in-sars-cov-2-ba286-and-jn1/</a>

Giuseppe MichieliImmune <a href="https://mstdn.science/tags/escape" class="mention hashtag" rel="nofollow noopener" target="_blank">#escape</a> and attenuated <a href="https://mstdn.science/tags/severity" class="mention hashtag" rel="nofollow noopener" target="_blank">#severity</a> associated with the <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> / <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://mstdn.science/tags/lineage" class="mention hashtag" rel="nofollow noopener" target="_blank">#lineage</a>Source: Nature Communications, AbstractThe SARS-CoV-2 BA.2.86 lineage, and its sublineage JN.1 in particular, achieved widespread transmission in the US during winter 2023–24. However, this surge in infections was not accompanied by COVID-19 hospitalizations and mortality commensurate with prior waves. To understand shifts in COVID-19 epidemiology associated with JN.1…<a href="https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/" rel="nofollow noopener" translate="no" target="_blank">https://etidioh.wordpress.com/2024/10/03/immune-escape-and-attenuated-severity-associated-with-the-sars-cov-2-ba286-jn1-lineage/</a>

Giuseppe MichieliStructural <a href="https://mstdn.science/tags/basis" class="mention hashtag" rel="nofollow noopener" target="_blank">#basis</a> for the <a href="https://mstdn.science/tags/evolution" class="mention hashtag" rel="nofollow noopener" target="_blank">#evolution</a> and <a href="https://mstdn.science/tags/antibody" class="mention hashtag" rel="nofollow noopener" target="_blank">#antibody</a> <a href="https://mstdn.science/tags/evasion" class="mention hashtag" rel="nofollow noopener" target="_blank">#evasion</a> of <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> and <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://mstdn.science/tags/subvariants" class="mention hashtag" rel="nofollow noopener" target="_blank">#subvariants</a> <a href="https://www.nature.com/articles/s41467-024-51973-8" rel="nofollow noopener" translate="no" target="_blank">https://www.nature.com/articles/s41467-024-51973-8</a> Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

J.H.Noyes<a href="https://www.prevention.com/health/health-conditions/a61423582/covid-summer-wave-2024/" rel="nofollow noopener" translate="no" target="_blank">https://www.prevention.com/health/health-conditions/a61423582/covid-summer-wave-2024/</a>A 'double-humped' summer season. That must be a polite way of saying 'double-fucked' as the United States is taking Covid at both ends.<a href="https://mastodon.online/tags/Covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid</a> <a href="https://mastodon.online/tags/SpitroastSummer" class="mention hashtag" rel="nofollow noopener" target="_blank">#SpitroastSummer</a> <a href="https://mastodon.online/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://mastodon.online/tags/Fauxmicron" class="mention hashtag" rel="nofollow noopener" target="_blank">#Fauxmicron</a>

Giuseppe MichieliRelative <a href="https://mstdn.science/tags/vaccine" class="mention hashtag" rel="nofollow noopener" target="_blank">#vaccine</a> <a href="https://mstdn.science/tags/protection" class="mention hashtag" rel="nofollow noopener" target="_blank">#protection</a>, <a href="https://mstdn.science/tags/disease" class="mention hashtag" rel="nofollow noopener" target="_blank">#disease</a> <a href="https://mstdn.science/tags/severity" class="mention hashtag" rel="nofollow noopener" target="_blank">#severity</a>, and <a href="https://mstdn.science/tags/symptoms" class="mention hashtag" rel="nofollow noopener" target="_blank">#symptoms</a> associated with the <a href="https://mstdn.science/tags/SarsCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#SarsCoV2</a> <a href="https://mstdn.science/tags/omicron" class="mention hashtag" rel="nofollow noopener" target="_blank">#omicron</a> <a href="https://mstdn.science/tags/subvariant" class="mention hashtag" rel="nofollow noopener" target="_blank">#subvariant</a> <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> and descendant <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> in <a href="https://mstdn.science/tags/Denmark" class="mention hashtag" rel="nofollow noopener" target="_blank">#Denmark</a>: a nationwide observational study <a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes" rel="nofollow noopener" translate="no" target="_blank">https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00220-2/fulltext?rss=yes</a> Although less effective against the new variants, XBB.1.5 vaccination remains protective and reduces the risk of infection and COVID-19 disease.

Giuseppe MichieliVirological characteristics of the <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://mstdn.science/tags/variant" class="mention hashtag" rel="nofollow noopener" target="_blank">#variant</a>, Cell: <a href="https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes" rel="nofollow noopener" translate="no" target="_blank">https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes</a>• BA.2.86 is more transmissible than the currently predominant <a href="https://mstdn.science/tags/EG51" class="mention hashtag" rel="nofollow noopener" target="_blank">#EG51</a> • The sensitivity of BA.2.86 to <a href="https://mstdn.science/tags/antiviral" class="mention hashtag" rel="nofollow noopener" target="_blank">#antiviral</a> <a href="https://mstdn.science/tags/drugs" class="mention hashtag" rel="nofollow noopener" target="_blank">#drugs</a> is comparable to that of EG.5.1 • The <a href="https://mstdn.science/tags/replication" class="mention hashtag" rel="nofollow noopener" target="_blank">#replication</a> efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1 • In hamsters, BA.2.86 is less <a href="https://mstdn.science/tags/pathogenic" class="mention hashtag" rel="nofollow noopener" target="_blank">#pathogenic</a> than EG.5.1 and the parental BA.2

Giuseppe Michieli<a href="https://mstdn.science/tags/Memory" class="mention hashtag" rel="nofollow noopener" target="_blank">#Memory</a> T <a href="https://mstdn.science/tags/cells" class="mention hashtag" rel="nofollow noopener" target="_blank">#cells</a> effectively recognize the <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 hypermutated <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://mstdn.science/tags/variant" class="mention hashtag" rel="nofollow noopener" target="_blank">#variant</a>, Cell: <a href="https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes" rel="nofollow noopener" translate="no" target="_blank">https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00505-X?rss=yes</a>• SARS-CoV-2 spike-specific T cells are profiled in healthy individuals and CLL patients • T cell cross-recognition of mutated BA.2.86 spike epitopes is largely preserved • BA.2.86-reactive T cells display features of high functional capacity

Giuseppe MichieliPostpandemic <a href="https://mstdn.science/tags/memory" class="mention hashtag" rel="nofollow noopener" target="_blank">#memory</a> T <a href="https://mstdn.science/tags/cell" class="mention hashtag" rel="nofollow noopener" target="_blank">#cell</a> response to <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 is durable, broadly targeted, & cross-reactive to hypermutated <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://mstdn.science/tags/variant" class="mention hashtag" rel="nofollow noopener" target="_blank">#variant</a>, Cell: <a href="https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes" rel="nofollow noopener" translate="no" target="_blank">https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00498-5?rss=yes</a>-- Spike-specific T cell memory responses are maintained into post-pandemic period • T cell cross-recognition is preserved against highly mutated variants such as BA.2.86 • Even prior to Omicron infection, reactivity to Omicron sub-lineages is conserved • Robust nucleocapsid- and membrane-specific T cells enlarge total T cell response

SARS2PAGood Morning SARS2PAians!I hope you're enjoying the milder weather and staying safe. :canparrot: __________ VOCsNationally, nothing really new. JN.1 everywhere, all over the place. Still over 80% of randomly tested sampling.: <a href="https://ibb.co/r6wyHdy" rel="nofollow noopener" target="_blank">https://ibb.co/r6wyHdy</a>In PA, Same thing, reflecting national levels.: <a href="https://ibb.co/b78MGWY" rel="nofollow noopener" target="_blank">https://ibb.co/b78MGWY</a>There is nothing so far on the mutation horizon that can compete with JN.1. As always there are a few concerning mutations out there, but sample numbers are low and variant hunters have not sent out any immediate warning signals.__________ WastewaterNationally, SARS2 matierial found in wastewater starting to take an unpleasant upturn again. 😓: <a href="https://ibb.co/PQkNZs6" rel="nofollow noopener" target="_blank">https://ibb.co/PQkNZs6</a>Regionally, the decline in levels has evened out again across all non-Eastern regions, and levels are rising in our area.: <a href="https://ibb.co/XWGNB1r" rel="nofollow noopener" target="_blank">https://ibb.co/XWGNB1r</a>In PA,levels rising slightly in Bucks and ChesterCo areas but heeeeeey Lackawanna, please stay safe and use some form of source control! Levels are waaaay up over there.: <a href="https://ibb.co/8XLYRgb" rel="nofollow noopener" target="_blank">https://ibb.co/8XLYRgb</a>The PA Wastewater dashboard has levels staying level for now except in the West Chester area.: <a href="https://ibb.co/C0BX4tY" rel="nofollow noopener" target="_blank">https://ibb.co/C0BX4tY</a>__________ CDCThe New Admits map is looking pretty good, except in the center fo the State and again in SchuylkillCo and the rest of the old coal region west of there, where level increases are substantial. Seems like this rather isolated area still has cases filtering through the health system.: <a href="https://ibb.co/vDM2rRL" rel="nofollow noopener" target="_blank">https://ibb.co/vDM2rRL</a>Lancaster Co also showing significant increases.The Inpatient Bed map also looking better, with some elevated counties up by Potter Co there, also somewhat in Berks. Nothing substantial which is.....OK.: <a href="https://ibb.co/12hc0HV" rel="nofollow noopener" target="_blank">https://ibb.co/12hc0HV</a>ICU bed use increased substantially in the center of the State (along I-80-ish) in CentreCo and counties west oif there, with smaller increses east of there too.: <a href="https://ibb.co/DMskC0W" rel="nofollow noopener" target="_blank">https://ibb.co/DMskC0W</a>Berks showing isngificant increases in ICU use. Berks/Lancaster seem to be having a tough time this winter. Please be safe there, get your most current COVID vaccinations and use source control! Don't become a statistic!Overall, the northern half of the US, including PA, is doing fairly well in controlling ILIs (influenza-like infections).: <a href="https://ibb.co/RvkZ8Hw" rel="nofollow noopener" target="_blank">https://ibb.co/RvkZ8Hw</a>Keep practing SOME form of source control (wearing a quality respirator, staying home when sick, do NOT send sick kids to school, avoiding large crowds, aware of social contacts, run those air purifiers, wash hands often to control non-SARS stuff like flu/norovirus etc.) and if we all do SOMETHING then we can keep this controlled for the arrival of Spring! 💐<a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/Covid19" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid19</a> <a href="https://zeroes.ca/tags/SARS2PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2PA</a> <a href="https://zeroes.ca/tags/CDC" class="mention hashtag" rel="nofollow noopener" target="_blank">#CDC</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/Pennsylvania" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pennsylvania</a> <a href="https://zeroes.ca/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a> <a href="https://zeroes.ca/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://zeroes.ca/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/CleanTheAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanTheAir</a> <a href="https://zeroes.ca/tags/VaccinesSaveLives" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccinesSaveLives</a> <a href="https://zeroes.ca/tags/Flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#Flu</a> <a href="https://zeroes.ca/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#Influenza</a> <a href="https://zeroes.ca/tags/RSV" class="mention hashtag" rel="nofollow noopener" target="_blank">#RSV</a> <a href="https://zeroes.ca/tags/Wastewater" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wastewater</a>

SARS2PAUpdate for 2/02/2024!Good Morning SARS2PAians!I hope you're staying dry with all this winter rain! (Sorry I haven't mirrored on Fedi for a while, i had major important stuff going on.)There's no new CDC stuff today, but also not much new info to write about in total, JN.1.11 doesn't seem to be taking off right now, and numbers are still doing very well in spite of colder weather (when air cleaning and freshening is a bit more difficult).THIS IS GOOD! I don't want to have any more news here ever! 🎊__________ VOCsNationally, nothing different yet. JN.1 and JN.1.4 still at the top. JN.1.11 still way down at 0.13% and though it's in 5 states and a few more sequences have been found, it hasn't risen above 1% yet.: <a href="https://ibb.co/wgZHftH" rel="nofollow noopener" target="_blank">https://ibb.co/wgZHftH</a>__________ WastewaterNationally, the decline is starting to level off a bit. Hopefully it continues down after more data is collected.: <a href="https://ibb.co/MkcDDX5" rel="nofollow noopener" target="_blank">https://ibb.co/MkcDDX5</a>Regionally, the West is ticking a bit upwards while everyone else is levelling off.: <a href="https://ibb.co/kXdhcTJ" rel="nofollow noopener" target="_blank">https://ibb.co/kXdhcTJ</a>In PA, the 5 stations reporting to Biobot are still doing fabulously. Luzerne and Lackawanna still quite above the national average though.: <a href="https://ibb.co/M1KzWJy" rel="nofollow noopener" target="_blank">https://ibb.co/M1KzWJy</a>According to PA's own wastewater monitoring site numbers are holding steady through the state except thre's an uptick in Franklin Co and over by Pottstown.: <a href="https://ibb.co/n3hfVrY" rel="nofollow noopener" target="_blank">https://ibb.co/n3hfVrY</a>FranklinCo: <a href="https://ibb.co/VCb9Z9N" rel="nofollow noopener" target="_blank">https://ibb.co/VCb9Z9N</a>Pottstown: <a href="https://ibb.co/0Jg6Gy8" rel="nofollow noopener" target="_blank">https://ibb.co/0Jg6Gy8</a>Please use caution to keep these numbers from going back up and causing life, learning, and financial loss.I just want to shoutout Erie Co since I lost track of there, Erie doesn't report to Biobot but it IS on the PA Wastewater dashboard.It's not only that Erie's numbers are low, it's that (except for a post-holiday small rise) the absolute baseline there is going down!! Look at that. : <a href="https://ibb.co/RyVt4bn" rel="nofollow noopener" target="_blank">https://ibb.co/RyVt4bn</a>That's amazing. Every county, State, and territories' chart should look like this. :canparrot: :canparrot: Thank you Erie! :canparrot: :canparrot: Another short update is a good update. Please keep using caution especially with at-risk people and in large public gatherings. Wear a quality respirator in places where there is tightly enclosed space with little ventilation (elevators, restrooms, large public closets, etc.)Keep that air fresh and clean and we'll be fantastic by Spring! ❄️❄️🌷<a href="https://zeroes.ca/tags/JN1Eleven" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1Eleven</a><a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/Covid19" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid19</a> <a href="https://zeroes.ca/tags/SARS2PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2PA</a> <a href="https://zeroes.ca/tags/CDC" class="mention hashtag" rel="nofollow noopener" target="_blank">#CDC</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/Pennsylvania" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pennsylvania</a> <a href="https://zeroes.ca/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a> <a href="https://zeroes.ca/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://zeroes.ca/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://zeroes.ca/tags/HV1" class="mention hashtag" rel="nofollow noopener" target="_blank">#HV1</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/CleanTheAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanTheAir</a> <a href="https://zeroes.ca/tags/VaccinesSaveLives" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccinesSaveLives</a> <a href="https://zeroes.ca/tags/Flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#Flu</a> <a href="https://zeroes.ca/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#Influenza</a> <a href="https://zeroes.ca/tags/RSV" class="mention hashtag" rel="nofollow noopener" target="_blank">#RSV</a> <a href="https://zeroes.ca/tags/Wastewater" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wastewater</a>

SARS2PAUpdate for 1/22/2024!Good Morning SARS2PAians!Warmer temperatures are ahead, finally, after this bitter cold spell.❄️❄️❄️__________ VOCsThere's not much new info out there and of course JN.1 and its child JN.1.4 still dominate the variant leaderboard, so this update will be brief as I have family stuff to do this morning anyway.It's all going to be about closely watching JN.1.11 (JN-one-eleven).It's now in 5 states as now it's been found in Washington State, and is spreading blazingly fast in India.JN.1.11 is now accounting for 0.13% of all random sequencing in the US, up from 0.8%. (Yes, it matters to watch it at those low numbers. Low numbers become top leaderboard numbers eventually!).: <a href="https://ibb.co/q92Mccf" rel="nofollow noopener" target="_blank">https://ibb.co/q92Mccf</a>__________ CDCThe new hospital admits map looks very much improved since last time. Still some increased activity in Philly, Pike Co, and Lawrence Co. Significant increases in Tioga.: <a href="https://ibb.co/n6YqkGj" rel="nofollow noopener" target="_blank">https://ibb.co/n6YqkGj</a>The Northeast US still struggles with lots of occupied inpatient beds. Lots of increases here as COVID filters through the medical system. Increases from Wayne Co down southwest through Huntingdon Co, over to Jefferson Co and up to Potter and McKean.: <a href="https://ibb.co/cyzjP7j" rel="nofollow noopener" target="_blank">https://ibb.co/cyzjP7j</a>ICU Beds now rising through the State too, especially in Berks, Lancaster, Franklin Co up through to Centre, and the northwest corner of the State excluding Crawford Co.: <a href="https://ibb.co/wNWptSH" rel="nofollow noopener" target="_blank">https://ibb.co/wNWptSH</a>The 3-month death metric unfortunately remains high in most states including PA, and if you compare to last week, this number is increasing steadily in a lot of States.: <a href="https://ibb.co/9TNjnkW" rel="nofollow noopener" target="_blank">https://ibb.co/9TNjnkW</a>We are sadly experiencing over 300 deaths a month from COVID, 1004 deaths in the past 3 months alone.❄️❄️❄️Don't become a statistic! Please keep wearing those quality respirators, keep the air clean, be aware of social contacts, and get those vaccinations! 😷❄️❄️❄️<a href="https://zeroes.ca/tags/JN1Eleven" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1Eleven</a><a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/Covid19" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid19</a> <a href="https://zeroes.ca/tags/SARS2PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2PA</a> <a href="https://zeroes.ca/tags/CDC" class="mention hashtag" rel="nofollow noopener" target="_blank">#CDC</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/Pennsylvania" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pennsylvania</a> <a href="https://zeroes.ca/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a> <a href="https://zeroes.ca/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://zeroes.ca/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://zeroes.ca/tags/HV1" class="mention hashtag" rel="nofollow noopener" target="_blank">#HV1</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/CleanTheAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanTheAir</a> <a href="https://zeroes.ca/tags/VaccinesSaveLives" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccinesSaveLives</a> <a href="https://zeroes.ca/tags/Flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#Flu</a> <a href="https://zeroes.ca/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#Influenza</a> <a href="https://zeroes.ca/tags/RSV" class="mention hashtag" rel="nofollow noopener" target="_blank">#RSV</a> <a href="https://zeroes.ca/tags/Wastewater" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wastewater</a>

SARS2PAUpdate for 1/19/2024!Good Morning SARS2PAians!So. How 'bout that snow? ❄️❄️❄️Please be cautious and don't travel today if you don't have to! (And don't travel even if you do have to, if you can help it!)There's no new CDC map stuff today.__________ VOCsNationally, JN.1 at the top of the leaderboard at over 32% of sequencing.: <a href="https://ibb.co/vsK3j09" rel="nofollow noopener" target="_blank">https://ibb.co/vsK3j09</a>Please remember ALL sequencing is very slow so these numbers are delayed by weeks. Its child JN.1.4 in second place at over 16%.In PA, JN.1 and its child mutation JN.1.4 at the top of the chart, reflecting naitonal levels.: <a href="https://ibb.co/Bcp6Skk" rel="nofollow noopener" target="_blank">https://ibb.co/Bcp6Skk</a>In NY/NJ, numbers also reflect national levels, ans the first few successful lineages are JN.1, JN.1.4, and HV.1.: <a href="https://ibb.co/WBk99sG" rel="nofollow noopener" target="_blank">https://ibb.co/WBk99sG</a>XDD is a recombinant that has potential to keep up with and even surpass JN.1.__________ Lineage NewsI want to bring your attention to two potentially problematic new mutations: Previously mentioned XDD (a recombo of EG.5.1.1 and JN.1,) and also especially JN.1.11.Note: That is J-N-ONE-ELEVEN, and I'll hashtag it here on the Fediverse as <a href="https://zeroes.ca/tags/JN1Eleven" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1Eleven</a> so it won't get confused with other names like JN.1.1.1 or JN.11.1. Understanding the correct lineage name is vital in tracking!JN.1.11 has a bonkers high estimated fitness (ability to reproduce, infect, take over the lineage leaderboard etc.) based on genomic info alone.: <a href="https://ibb.co/J28MbXh" rel="nofollow noopener" target="_blank">https://ibb.co/J28MbXh</a>It was only sequenced this month and is already in 5 countries: India, USA, Singapore, Israel, and the UK.It's already in at least 4 US States: TX, CO, MD and NC.: <a href="https://ibb.co/vDhvmX2" rel="nofollow noopener" target="_blank">https://ibb.co/vDhvmX2</a>Reminder that the JN.x.y series also as a whole has a bonkers high estimated fitness and binding ability based on genomics alone that you can see here on the ACE2/Immune Escape estimation graph.: <a href="https://ibb.co/cJ7dLRT" rel="nofollow noopener" target="_blank">https://ibb.co/cJ7dLRT</a>Numbers in wastewater are starting to go down from the original JN.1, but the trouble with this JN.1 clan is it mutates quickly AND all of it is fast. It has the potential to raise the absolute baseline high and keep it there so it never goes down IF we all do not practice some form of source control.Schools as they open will contribute to rising cases and increased absences all over the place, for kids AND for adults. The way to combat this is source control.__________ WastewaterNationally, SARS2 in wastewater starting to decline.: <a href="https://ibb.co/ftKcw5N" rel="nofollow noopener" target="_blank">https://ibb.co/ftKcw5N</a>Regionally, the Northeast on a sharp downturn and the rest of the regions holding steady or ever so slightly declining.: <a href="https://ibb.co/KbjPYLR" rel="nofollow noopener" target="_blank">https://ibb.co/KbjPYLR</a>Please don't get comfy with this until we know how schoolkids are going to fare.In PA, the 5/11 Biobot up-to-date sheds are showing a promising downturn, ChesterCo and BucksCo down to meeting the national average level again.: <a href="https://ibb.co/0MTv8cm" rel="nofollow noopener" target="_blank">https://ibb.co/0MTv8cm</a>MontCo is back to smashing it going BELOW national levels!According to the PA DOH wastewater site (thank you so much to a supercool Fediverse reader that pointed this site out for me!!...thank you lemon❤️️) sheds in CentreCo, near Philly and in MonroeCo are experiencing increases in tested SARS2 material.: <a href="https://ibb.co/BgDtfH0" rel="nofollow noopener" target="_blank">https://ibb.co/BgDtfH0</a>On WastewaterSCAN, levels are still HIGH nationally for SARS2, RSV, and Norovirus (which is the "24hr stomach thing" from tainted surfaces/food). Make sure your utensils and eating places are cleaning things properly...this stuff's just gross 🤢: <a href="https://ibb.co/LSnpD2j" rel="nofollow noopener" target="_blank">https://ibb.co/LSnpD2j</a>We are not out of the woods yet with this illness season. PLEASE practice some source control as this blazing fast JN.x.y clan takes over and can push numbers way up if we get hit with multiple very fit variants at once. NOWCASTThe latest NOWCAST from CDC is out. JN.1 estimated at 85% of cases this week! 👀🚀👀🚀👀🚀: <a href="https://ibb.co/LS53WZH" rel="nofollow noopener" target="_blank">https://ibb.co/LS53WZH</a>Lots of junk out there and JN.x.y is some seriously fast business. Please :canparrot: doooooooooo the source control :canparrot: and we can prevent life, learning, and financial loss and have an easy transition into spring! 😷😷😷(And be careful out there today too ❄️❄️❄️)<a href="https://zeroes.ca/tags/JN1Eleven" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1Eleven</a><a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/Covid19" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid19</a> <a href="https://zeroes.ca/tags/SARS2PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2PA</a> <a href="https://zeroes.ca/tags/CDC" class="mention hashtag" rel="nofollow noopener" target="_blank">#CDC</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/Pennsylvania" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pennsylvania</a> <a href="https://zeroes.ca/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a> <a href="https://zeroes.ca/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://zeroes.ca/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://zeroes.ca/tags/HV1" class="mention hashtag" rel="nofollow noopener" target="_blank">#HV1</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/CleanTheAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanTheAir</a> <a href="https://zeroes.ca/tags/VaccinesSaveLives" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccinesSaveLives</a> <a href="https://zeroes.ca/tags/Flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#Flu</a> <a href="https://zeroes.ca/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#Influenza</a> <a href="https://zeroes.ca/tags/RSV" class="mention hashtag" rel="nofollow noopener" target="_blank">#RSV</a> <a href="https://zeroes.ca/tags/Wastewater" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wastewater</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Macau" class="mention hashtag" rel="nofollow noopener" target="_blank">#Macau</a>, Serviços de Saúde apelam aos residentes para prestarem maior <a href="https://mstdn.science/tags/aten%C3%A7%C3%A3o" class="mention hashtag" rel="nofollow noopener" target="_blank">#atenção</a> à <a href="https://mstdn.science/tags/preven%C3%A7%C3%A3o" class="mention hashtag" rel="nofollow noopener" target="_blank">#prevenção</a> do vírus <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#influenza</a> e da <a href="https://mstdn.science/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#COVID19</a> devido ao crescimento dos casos em Macau <a href="https://www.gcs.gov.mo/detail/pt/N24ALK8Q5a" rel="nofollow noopener" translate="no" target="_blank">https://www.gcs.gov.mo/detail/pt/N24ALK8Q5a</a> <a href="https://mstdn.science/tags/EG5" class="mention hashtag" rel="nofollow noopener" target="_blank">#EG5</a> <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a>

SARS2PAGood Morning SARS2PAians!I hope you have a restful and powerful holiday today! ✊Thre's not much new info out today. No Tableau stuff, no wastewater.__________ CDCCDC has released new per-county information, though.The new hospital admits map has improved quite a bit for now, the post-holiday pre-school timeslot. Cases are still substantially increasing in the counties along south of I-80, and north up to Potter and McKean Cos.: <a href="https://ibb.co/zSCd72n" rel="nofollow noopener" target="_blank">https://ibb.co/zSCd72n</a>Also in Crawford, Franklin and Fulton Cos.The map showing inpatient beds has gotten only slightly better, still a LOT of counties showing substantial and high increases.: <a href="https://ibb.co/ZxS1yYN" rel="nofollow noopener" target="_blank">https://ibb.co/ZxS1yYN</a>A direct result of waning immunity considering most people not getting current vaccines...XBB or even their bivalents from last year.Substantial increases east of Potter Co, east of Luzerne Co, in Berks, and east of Juniata.ICU bed occupation near the Philly area and surrounding counties has considerably lessened since last update where this area in particular was experiencing high levels.: <a href="https://ibb.co/n8vsDst" rel="nofollow noopener" target="_blank">https://ibb.co/n8vsDst</a>Now everywhere else but Philly and surrounding counties are showing substantial and high levels. Again, those counties are the same already mentioned...East of Juniata, east of Luzerne, Berks, and along the western half of the NY border counties. Also in Mercer Co.C19 Emergency Dept visits are nationwide on the low side except here in the Northeast.: <a href="https://ibb.co/mbdkxDq" rel="nofollow noopener" target="_blank">https://ibb.co/mbdkxDq</a>Unfortunately, as of Jan.11th, there have been 1,026 deaths from Covid-19 in PA in the past 3 months. (PLEASE NOTE this number keeps rising monthy.): <a href="https://ibb.co/xmjvw2d" rel="nofollow noopener" target="_blank">https://ibb.co/xmjvw2d</a>PA, and in fact the majority of states, are in the highest CDC percentage category of states with COVID deaths in a 3 month roling period.__________ JN.1 NewsAlong with 11 NYC public hospitals, mask mandates have returned to NYC EMS for their fire/ambulance emergency services.: <a href="https://www.msn.com/en-us/health/other/mask-mandate-returns-for-fdny-fire-ambulance-personnel-amid-rise-in-covid-other-viruses/ar-AA1mVNAu" rel="nofollow noopener" target="_blank">https://www.msn.com/en-us/health/other/mask-mandate-returns-for-fdny-fire-ambulance-personnel-amid-rise-in-covid-other-viruses/ar-AA1mVNAu</a>China is issuing stern warnings about JN.1, but I want to draw attention to the last paragraph of this article in particular: <a href="https://news.cgtn.com/news/2024-01-14/China-warns-on-possible-rebound-of-COVID-19-JN-1-subvariant-1qmE7pROeGY/p.html" rel="nofollow noopener" target="_blank">https://news.cgtn.com/news/2024-01-14/China-warns-on-possible-rebound-of-COVID-19-JN-1-subvariant-1qmE7pROeGY/p.html</a> ""High-risk groups like pregnant women, children and the elderly should prioritize annual influenza vaccination and maintain healthy habits," Wang advised. He further stressed the importance of understanding that contracting one type of respiratory illness does not guarantee immunity against others in the short term."Please, folks, keep up with all available respiratory vaccinations, not just COVID.Encourage children to mask up with quality respirators when they go back to school. If we are cautious until the Spring it's going to save us going through some things in the long run!! 😷😷😷:canparrot: <a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/Covid19" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid19</a> <a href="https://zeroes.ca/tags/SARS2PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2PA</a> <a href="https://zeroes.ca/tags/CDC" class="mention hashtag" rel="nofollow noopener" target="_blank">#CDC</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/Pennsylvania" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pennsylvania</a> <a href="https://zeroes.ca/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a> <a href="https://zeroes.ca/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://zeroes.ca/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://zeroes.ca/tags/HV1" class="mention hashtag" rel="nofollow noopener" target="_blank">#HV1</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/CleanTheAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanTheAir</a> <a href="https://zeroes.ca/tags/VaccinesSaveLives" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccinesSaveLives</a> <a href="https://zeroes.ca/tags/Flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#Flu</a> <a href="https://zeroes.ca/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#Influenza</a> <a href="https://zeroes.ca/tags/RSV" class="mention hashtag" rel="nofollow noopener" target="_blank">#RSV</a> <a href="https://zeroes.ca/tags/Wastewater" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wastewater</a>

SARS2PAGood Day Fediverse, SARS2PAians!A bit late for me to mirror this on the Fediverse (sorry), but here's the 1/12/2024 update!There's no new CDC hospitalization data today.__________ VOCsNationally, JN.1 solidly in the lead with over 27% leaderboard share in random sequencing.: <a href="https://ibb.co/7QdWsxz" rel="nofollow noopener" target="_blank">https://ibb.co/7QdWsxz</a>In PA, HV.1 in the lead...but not by much, 16% vs. 17%. Weird.: <a href="https://ibb.co/rd18RCq" rel="nofollow noopener" target="_blank">https://ibb.co/rd18RCq</a>But, I would think that if JN.1 isn't blazing fast here like in other places, especially being close to densely infected metro areas like NY and Jersey, we're doing something right.We're wearing respirators, keeping close watch of social contacts, and keeping the air clean.Everyone can snd should practice SOME form of source control. IT WORKS! 😎IN NY/NJ, JN.1 at 37% of share.: <a href="https://ibb.co/tDsZqTS" rel="nofollow noopener" target="_blank">https://ibb.co/tDsZqTS</a>JN.1.4 is one of a few upcoming variants that have potential to compete with JN.1 but will most likely not actually take over. The JNs will probably just take over more and more of the share from everything else below it.There's nothing that can take over JN.1.Yet.___________ WastewaterNationally, SARS2 wastewater is starting to level off a bit.: <a href="https://ibb.co/nMgxSvz" rel="nofollow noopener" target="_blank">https://ibb.co/nMgxSvz</a>Don't get comfortable, the kids still have to go back to school.: <a href="https://ibb.co/FnFLrzc" rel="nofollow noopener" target="_blank">https://ibb.co/FnFLrzc</a>Regionally, the Northeast is still going slightly up but the growth is slowing. The rest of the regions are stable and not rising.: <a href="https://ibb.co/2YV5D0Z" rel="nofollow noopener" target="_blank">https://ibb.co/2YV5D0Z</a>In PA, 4/11 sheds reporting naything close to current, and those sheds are all going vertical. The small drop at the end is usually due to incomplete data and not an actual drop in material.: <a href="https://ibb.co/2YV5D0Z" rel="nofollow noopener" target="_blank">https://ibb.co/2YV5D0Z</a>If you look at the cumulative data through this whole thing, you can see easily that in BucksCo and in the other current data sheds (Lackawanna, Luzerne, MontCo) that this is the second highest rise in material throughout the pandemic.BucksCo: <a href="https://ibb.co/DCCGwrz" rel="nofollow noopener" target="_blank">https://ibb.co/DCCGwrz</a>Other sheds: <a href="https://ibb.co/brCcRQF" rel="nofollow noopener" target="_blank">https://ibb.co/brCcRQF</a>And the concentration is VERY HIGH at over (EDIT:) 2000m/L.This rise is NOT due to persistence in the gut and extreme shedding through GI issues, but rather due to actual reinfections.: <a href="https://ibb.co/5KK6LR9" rel="nofollow noopener" target="_blank">https://ibb.co/5KK6LR9</a>:ms_arrow_right: Maria Van Kekhove, a director at the WHO, tweeted: "What is driving circulation is an evolving virus (now JN.1 represents >50% of sequences shared for global analysis) that is reinfecting people in all countries, limited or no public health and social measures used to limit exposure, and many other factors"__________ CDCThe most current At-A-Glance graphic still has the country trending the wrong way.: <a href="https://ibb.co/RbGdvDv" rel="nofollow noopener" target="_blank">https://ibb.co/RbGdvDv</a>Most states are in HIGH, VERY HIGH or EXTREME levels of Influenza-Like Illnesses (ILI), a combo of a bunch of things like COVID, FluA, FLuB, parainfluenza, colds, etc.: <a href="https://ibb.co/L1n896y" rel="nofollow noopener" target="_blank">https://ibb.co/L1n896y</a>Please take caution now because this could make us all go through some things when these kids go back to school.Wear a respirator, have those kids wear them. :canparrot: Clean the air, use those CR boxes/HEPA filters! :canparrot:Keep track of social contacts :canparrot:Ventilate when possible/weather permits :canparrot:Keep unnecessary travel to a minimum :canparrot: (<---i love this parrot LOL)If we use caution now the back-to-school fallout won't disrupt the health care system, and we'll all be much happier! 😷😷😷<a href="https://zeroes.ca/tags/covid" class="mention hashtag" rel="nofollow noopener" target="_blank">#covid</a> <a href="https://zeroes.ca/tags/Covid19" class="mention hashtag" rel="nofollow noopener" target="_blank">#Covid19</a> <a href="https://zeroes.ca/tags/SARS2PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS2PA</a> <a href="https://zeroes.ca/tags/CDC" class="mention hashtag" rel="nofollow noopener" target="_blank">#CDC</a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#CovidIsNotOver</a> <a href="https://zeroes.ca/tags/Pennsylvania" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pennsylvania</a> <a href="https://zeroes.ca/tags/PA" class="mention hashtag" rel="nofollow noopener" target="_blank">#PA</a> <a href="https://zeroes.ca/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://zeroes.ca/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> <a href="https://zeroes.ca/tags/HV1" class="mention hashtag" rel="nofollow noopener" target="_blank">#HV1</a> <a href="https://zeroes.ca/tags/WearAMask" class="mention hashtag" rel="nofollow noopener" target="_blank">#WearAMask</a> <a href="https://zeroes.ca/tags/CleanTheAir" class="mention hashtag" rel="nofollow noopener" target="_blank">#CleanTheAir</a> <a href="https://zeroes.ca/tags/VaccinesSaveLives" class="mention hashtag" rel="nofollow noopener" target="_blank">#VaccinesSaveLives</a> <a href="https://zeroes.ca/tags/Flu" class="mention hashtag" rel="nofollow noopener" target="_blank">#Flu</a> <a href="https://zeroes.ca/tags/Influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#Influenza</a> <a href="https://zeroes.ca/tags/RSV" class="mention hashtag" rel="nofollow noopener" target="_blank">#RSV</a> <a href="https://zeroes.ca/tags/Wastewater" class="mention hashtag" rel="nofollow noopener" target="_blank">#Wastewater</a>

Giuseppe Michieli-- <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a>’s <a href="https://mstdn.science/tags/spike" class="mention hashtag" rel="nofollow noopener" target="_blank">#spike</a> protein has just 1 more <a href="https://mstdn.science/tags/mutation" class="mention hashtag" rel="nofollow noopener" target="_blank">#mutation</a> than <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a>’s spike. That mutation, called <a href="https://mstdn.science/tags/L455S" class="mention hashtag" rel="nofollow noopener" target="_blank">#L455S</a>, enhances the virus’ ability to bind to the angiotensin-converting enzyme 2 (<a href="https://mstdn.science/tags/ACE2" class="mention hashtag" rel="nofollow noopener" target="_blank">#ACE2</a>) <a href="https://mstdn.science/tags/receptor" class="mention hashtag" rel="nofollow noopener" target="_blank">#receptor</a>, SARS-CoV-2’s doorway into cells, Nicole Doria-Rose, PhD, chief of the Humoral Immunology Core at the NIAIDs’ Vaccine Research Center, noted in an interview with JAMA.

Dr Emma Hodcroft :verified:📢<a href="http://CoVariants.org" rel="nofollow noopener" translate="no" target="_blank">http://CoVariants.org</a> Update📢23G (XBB.1.5.70) 23H (HK.3) & 23I (BA.2.86) are now available on CoVariants! They are visible as part of Per Country & Per Variant plots, on the shared mutation page, & on their individual pages<a href="https://mstdn.science/tags/23G" class="mention hashtag" rel="nofollow noopener" target="_blank">#23G</a> <a href="https://mstdn.science/tags/23H" class="mention hashtag" rel="nofollow noopener" target="_blank">#23H</a> <a href="https://mstdn.science/tags/23I" class="mention hashtag" rel="nofollow noopener" target="_blank">#23I</a> <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> <a href="https://mstdn.science/tags/HK3" class="mention hashtag" rel="nofollow noopener" target="_blank">#HK3</a>1/8

Giuseppe MichieliHumoral immune <a href="https://mstdn.science/tags/escape" class="mention hashtag" rel="nofollow noopener" target="_blank">#escape</a> by current <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/variants" class="mention hashtag" rel="nofollow noopener" target="_blank">#variants</a> <a href="https://mstdn.science/tags/BA286" class="mention hashtag" rel="nofollow noopener" target="_blank">#BA286</a> and <a href="https://mstdn.science/tags/JN1" class="mention hashtag" rel="nofollow noopener" target="_blank">#JN1</a> December 2023 <a href="https://pubmed.ncbi.nlm.nih.gov/38214083/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1tcbYKHhYJMVv9EYVIXTv68QlnI8VGVDqIu1-nD9hvHuYbKgNG&fc=None&ff=20240112095729&v=2.18.0" rel="nofollow noopener" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/38214083/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1tcbYKHhYJMVv9EYVIXTv68QlnI8VGVDqIu1-nD9hvHuYbKgNG&fc=None&ff=20240112095729&v=2.18.0</a>-- We tested live virus neutralisation of sera taken in Sept 23 from vaccinated and exposed healthy persons (n = 39). We found clear neutralisation escape against recent variants but no specific pronounced escape for BA.2.86 or JN.1. Neutralisation escape corresponds to recent variant predominance but may not be causative of the recent upsurge in JN.1 incidence.

Continued thread

**Giuseppe Michieli** @GMIK69@mstdn.science · Jan 9, 2024

Jan 9, 2024

Giuseppe Michieli @GMIK69@mstdn.science

-- These observations suggest that a single dose of #XBB15 monovalent #vaccine potentially induces antiviral humoral #immunity against XBB subvariants as well as #BA286 without previous infection.

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