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#antibody

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Cancer #immunotherapy (immuno-oncotherapy) is the stimulation of the #immuneSystem to treat cancer, improving the immune system's natural ability to fight the disease. It is an application of the #fundamentalResearch of #cancerImmunology (immuno-#oncology) and a growing subspecialty of oncology. Cancer immunotherapy exploits the fact that #cancerCells often have #tumorAntigens, molecules on their surface that can bind to #antibody #proteins or #TcellReceptors.

Structural basis of broad #protection against #influenza virus by a #human #antibody targeting the #neuraminidase active site via a recurring motif in CDR H3

Source: BioRxIV, AbstractInfluenza viruses evolve rapidly, driving seasonal epidemics and posing global pandemic threats. While neuraminidase (NA) has emerged as a vaccine target, shared molecular features of NA antibody responses are still not well understood. Here, we describe cryo-electron microscopy structures…

etidioh.wordpress.com/2024/12/

ETIDIoH · Structural basis of broad #protection against #influenza virus by a #human #antibody targeting the #neuraminidase active site via a recurring motif in CDR H3
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Protective threshold of a potent neutralizing #Zika virus monoclonal #antibody in rhesus #macaques

Source: Journal of Virology, ABSTRACTZika virus (ZIKV) is a mosquito-borne flavivirus that caused a global pandemic in 2016–2017 with continued ongoing transmission at low levels in several countries. In the absence of an approved ZIKV vaccine, neutralizing monoclonal antibodies (mAbs) provide an option for the prevention and treatment of ZIKV infection. Previous studies…

etidioh.wordpress.com/2024/11/

ETIDIoH · Protective threshold of a potent neutralizing #Zika virus monoclonal #antibody in rhesus #macaques
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