Big news in ADPKD research!
Total kidney volume evolution over 2y
Pooled analysis of 820 patients planned!
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Just heard that the Cilia2024 conference is almost fully booked! 
Hurry and grab the last on-site spots for the world's biggest cilia meeting in beautiful Dublin!
Last-minute industry sponsors are welcome!
Online participation in this hybrid meeting is, of course, not limited.
Webpage: https://cilia2024.ie/
#Cilia2024 #Ciliopathies #RareDisease #ADPKD #PCD #BBS #NPHP #Centrosome #Centriole #CellBiology #DevelopmentalBiology #Nephrology #Neurology #EMBO @cilia @cellbiology
Herzlichen Dank an Roman Stilling & Johannes Beckers für die Einladung zum Podcast "Fabeln, Fell und Fakten" und zum intensiven Austausch über Nierenforschung, Krankheitsmodelle und Nachhaltigkeit im Forschungslabor - losgetreten durch die Tagung des 3R-Kompetenznetzwerk NRW.
Hier geht es zur Podcast-Folge: https://www.tierversuche-verstehen.de/3f-podcast/
#Nachhaltigkeit #3RNRW #Niere #Nephrologie #Forschung #Zilien #Organoide #3R #ADPKD @cilia @UniKoeln
@NeuRoman_cer
There are less than nine months remaining until Cilia2024, happening from September 10th to 13th in Dublin! 
Remember to mark your calendars! What an amazing lineup of programs and speakers!
For more information, visit http://cilia2024.ie/
Registration opens in February.
@cilia @cellbiology @cellbio
#CellBiology #DevelopmentalBiology #DevBio #Nephrology #Ciliopathies #cilia #Science #Conference #RareDiseases #Kidney #Biology #Flagella #PCD #ADPKD #BBS #NPHP #CKD #PKD
We are looking for a PhD candidate!
Topic:
Primary Cilia and Renal Ciliopathies as part of our work within #Theracil
Please apply via 
to me (you will find the address on our webpage) or via DM.
#Ciliopathies #Cilia #CysticKidneyDisease #NPHP #ADPKD #Nephrolab
@UniKoeln @CECAD
@cilia
www.kidneyresearchcenter.orgNephrolab
Very happy to be back home in #AotearoaNZ for the #ANZSN meeting. Learning about drug screening using kidney organoids for #ADPKD research from university of #auckland Dr Veronika Sander
Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion. https://doi.org/10.1186/s10020-023-00664-z #PolycysticKidneyDisease #Pkd #Adpkd #DrugRepurposing #SignatureReversion
Continued thread
A downstream effect is that this has lead to a premature halting of the FALCON trial of #Bardoxolone in #ADPKD N = 809 https://clinicaltrials.gov/ct2/show/NCT03918447
via this https://pkdcure.org/why-did-the-falcon-clinical-trial-end/
I guess the molecule is mostly dead?
5/
clinicaltrials.govA Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON - Full Text View - ClinicalTrials.govA Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON - Full Text View.
Just found this on the bird net
Delighted to distribute the announcement of the 6th European Cilia conference CILIA2024
I can't wait to meet everyone and present our work in Dublin!
To those not familiar with cilia and flagella: these are the greatest organelles of all
#Cilia2024 #Cilia2022 #RareDisease #ADPKD #BBS
#DevBiol #CellBiology #Science
@cilia
Morgen Vormittag
9:15 - 12:45 Uhr
Nephrologie Aktuell 2023
an der Uniklinik Köln
(oder online).
Anmeldung online:
https://events.teams.microsoft.com/event/491199e7-c4b8-47d9-99f2-44204dab5324@026d9967-161f-492f-8131-a0f456c4c2c8
Anmeldung on-site:
nephrologie@uk-koeln.de
If #nephmadness has reinvigorated your interest in learning about kidney disease then check out this #tweetorial - emerging therapies for #ADPKD 
---
RT @ckd_ce
1) Welcome to our new #accredited #tweetorial on Current and Emerging #Therapies in Management of #ADPKD. I am Fouad Chebib, MD, FASN (@fouadchebib), Consultant & Assistant Professor of Medicine, Nephrology & Hypertension @MayoClinicNeph, Jacksonville, FL 
.
https://twitter.com/ckd_ce/status/1638496179540434948
Happy #WorldKidneyDay, everyone! The kidneys are amazing & childhood is a unique opportunity for preventative healthcare - if you'd like to learn more about the non-clinical management of #ADPKD in childhood, then check out this #tweetorial
@KidneyHealth
---
RT @ckd_ce
1a) Welcome to a new #accredited #tweetorial on Nonclinical Considerations in Management of #ADPKD in Childhood! Our expert author is Cathy Quinlan MD @KidneyCathy, acade…
https://twitter.com/ckd_ce/status/1633783565941895169
TwitterTweet / Twitter
ADPKD is generally viewed as an adult disease but it can impact children too. Read this tweetorial to find out more
---
RT @ckd_ce
1) Welcome to a new #accredited #tweetorial on #childhood #ADPKD. This program is part of our ongoing series of education on ADPKD. 
Prior programs still available for credit at https://ckd-ce.com/category/adpkd/. Follow this 
for
0.75hr CE/#CME!
https://twitter.com/ckd_ce/status/1630528016697761793
ckd-ce.comadpkd | CKD CE
Great catching up with the awesome Osama Amro and talking all things #ADPKD #polycystickidneydisease
@TuftsMCKidney@twitter.com
Excited to lead the @ucsdnephrology@twitter.com #ADPKD Center of Excellence. Thanks @PKDFoundation@twitter.com for this designation and the @UCSDHealth@twitter.com team for making this possible. Look forward to providing high level, comprehensive, multi-disciplinary care. @PKDFSanDiego@twitter.com
https://today.ucsd.edu/story/uc-san-diego-health-named-center-of-excellence-for-polycystic-kidney-disease
today.ucsd.eduUC San Diego Health Named Center of Excellence for Polycystic Kidney DiseaseUC San Diego Health has been named a Center of Excellence for polycystic kidney disease (PKD) by the PKD Foundation – the leading advocacy group dedicated to finding treatments and a cure for PKD. UC San Diego Health is one of just 28 institutions nationwide to receive this designation.
Continued thread
Welcome to the German PKD group, PKD e.V. !!!
Great to see you on Mastodon! 
It is our big concern that with Twitter an important connection between patients and scientists could break away ... Wonderful meeting you here! 
Herzlich Willkommen,. PKD e.V. ! Toll, dass Sie jetzt auch auf Mastodon sind!
Es ist unsere große Sorge, dass mit Twitter ein wichtiger Link zwischen Patient:innen und Wissenschaftler:innen wegbrechen könnte und die Alternative nur langsam in Gang kommt. Daher ist es super, dass PKD e.V. hier an Bord ist!
A short-term KDIs potently induce ketogenesis and are feasible for ADPKD patients in daily life. While Tota Liver Volume quickly changed upon the onset of ketogenesis, changes in Tota Kidney Volume may require longer-term interventions.
#ADPKD #endPKD
https://academic.oup.com/HTTPHandlers/Sigma/LoginHandler.ashx?error=login_required&state=0512fa51-bc1c-41d9-aded-b223903a32d6redirecturl%3Dhttpszazjzjacademiczwoupzwcomzjndtzjadvancezyarticlezyabstractzjdoizj10zw1093zjndtzjgfac311zj6845752
A short-term #KetogenicDiet potently induce ketogenesis in people with #ADPKD- #TLV quickly changes upon the onset of ketogeneses but no reduction in #TKV
https://academic.oup.com/ndt/advance-article-abstract/doi/10.1093/ndt/gfac311/6845752
OUP AcademicRESET-PKD: A pilot trial on short-term ketogenic interventions in autosomal dominant polycystic kidney diseaseAbstractBackground. Ketogenic dietary interventions (KDI) have been shown to be effective in animal models of polycystic kidney disease, but data from clinical
Kidney epithelial #Tubuloid
CD24+ epithelial progenitor-derived
4-phase protocol, Matrigel +Wnt3a/RSPO1, grow > 6 mo
CRISPR modeling #ADPKD, Cyst size responsive to #Tolvaptan
Super-impressive single-cell or single-nuclei RNAseq analyses to dissect the spatiotemporal molecular/cellular dynamics of this cool renal tubuloid, laying a critical foundation to enhance its clinical utilities
Wonderful #Lumenogenesis of CD24+ epithelial progenitor-derived nephrospheres, day 7 in Matrigel
Dr. Rafael Kramann lab @NatureGenet 2022 @jackxuyx @KuppeChristoph @rkramann
https://www.nature.com/articles/s41588-022-01202-z
GIF