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Rio Sugimura

RT @Lo_Zanzi@twitter.com

! Tissues with lot of apoptotic cells (BM, spleen, …) are hypoxic. ⁦@ThePerryLab@twitter.com⁩ shows ⁦@Cell_Metabolism@twitter.com⁩ that prolonged hypoxia makes macrophages more efferocytic via the potentiation of the Pentose Phosphate Pathway cell.com/cell-metabolism/fullt

🐦🔗: twitter.com/Lo_Zanzi/status/16

Cell MetabolismMetabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environmentsTissues pose distinct challenges that macrophages must overcome, including limited nutrient availability (glucose, oxygen), to perform essential functions such as apoptotic cell clearance (efferocytosis). Here, Wang et al. find that macrophages undergo novel metabolic adaptations to prolonged physiological hypoxia that directly support rapid, efficient efferocytosis.
Dec 30, 2022, 01:49 AM·Quiet public·Mastodon Twitter Crossposter
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