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@rchusid@med-mastodon.comPrior Covid infection reduces immune response to vaccine.
#COVID #vaccines https://www.cell.com/immunity/fulltext/S1074-7613(23)00125-5
ImmunitySpheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infectionOur understanding of T cell responses in COVID-19 and vaccination is incomplete. Gao
et al. examine SARS-CoV-2-specific T cell responses to infection and vaccination,
revealing disparate kinetics between CD4+ and CD8+ T cells. Furthermore, compared
with vaccination alone, circulating CD8+ T cells are attenuated during infection and
in subsequent vaccination.
NIH summary on study re prior Covid infection reducing immune response to vaccine:
National Institutes of Health (NIH) · SARS-CoV-2 infection weakens immune-cell response to vaccinationNIH-funded study suggests need to boost CD8+ T cell response after infection.
@rchusid I need a “dummies” version of this. The more I read, the less I understood.
@rchusid Much better! I can edubabble all day long, but I don’t science much.
@rchusid Not great news, however "[i]mportantly, people who recover from SARS-CoV-2 infection and then get vaccinated are more protected than people who are unvaccinated."