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Now that we understand how PEEP effects the lungs, we also need to consider how PEEP effects the heart.

We've already talked about how larger volumes can increase PVR. This increases RV afterload & right sided pressures.

For the 25% of the population with a PFO, this rise in right sided pressures may cause R-->L shunt, causing hypoxemia due to an intra-cardiac shunt.
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