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IL-6 is such a fascinating cytokine.
Here it is modulating different dendritic cell subsets
@JExpMed
#immunology #DC #cytokine #science
https://rupress.org/jem/article/220/10/e20221757/214227/IL-6-selectively-suppresses-cDC1-specification-via?guestAccessKey=48cccc06-d788-423c-889f-51498d95a918&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2ph4e3-co3ru7-cwe4ixj2
@gpollara @JExpMed Intriguing. In an earlier postdoc position I had a look at #DendriticCells, and especially the #cDC1 were abundant, but seemed to be just sitting in the inflammatory environment, doing little. One of the very abundant cytokines: #IL6
We also looked at the effect of that and other #cytokines, but mostly on #Tcells, among others due to the low abundance of cDC1 in HC blood to be able to do many in vitro experiments.
@tinyspheresof @JExpMed v cool - and what did you find re IL-6? It's so abundant and yet difficult to know what exactly it does!
The work on the DC - quite descriptive - is published. Find it here: https://mastodon.social/@tinyspheresof/109681388538649498
The T cell work has not been published. I think I have a mostly complete manuscript that I could put on bioRXv. I'll discuss it with my former PI.
The short version: #IL6 and #TNF were very abundant, and were in the way of Treg-Teff interaction, #Teff not reacting to #Treg suppression anymore. Possibly partly explaining why drugs against these work in #arthritis.