Such a neat story about bacterial virulence factor (EsxM) contributing to bone dissemination of TB disease through actions on macrophage motility. @cellpress
Unlikely to be the whole story, and it's taking a leap from zebrafish model to extrapolate human TB disease phenotype, but v plausible that bacterial manipulation of host immunobiology can alter natural history of #TB disease. #immunology #macrophages #granuloma #bone
https://www.cell.com/cell/fulltext/S0092-8674(22)01361-7?dgcid=raven_jbs_etoc_email