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https://www.bbc.com/news/articles/c1wwdd6v2wjo “The group of researchers at the Francis Crick Institute and University College London performed a deep genetic analysis to try to unpick the cause of the #IBD.
They discovered a section of genetic code – or #DNA – that turns out to be the #macrophage’s “master regulator” of #inflammation.
It sits right at “the top of the pyramid” says Dr James Lee, from the Francis Crick Institute. (1/2)
www.bbc.comMajor cause of inflammatory bowel disease foundScientists have found a weak spot in our DNA that is present in 95% of people with the disease.
The gene controls the suite of inflammatory chemicals the macrophages release, and some people are born with a version that make their body prone to responding excessively.” (2/2)
NatureA disease-associated gene desert directs macrophage inflammation through ETS2 - NatureETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.