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@Kaminskimed@med-mastodon.comRT @harshameghadri@twitter.com
A bit late share but a really cool work by @BREATH_Hannover@twitter.com @jonas_schupp@twitter.com @KaminskiMed@twitter.com and co-authors looking at Src inhibitors on reversing gene expression signatures in IPF using CLUE/L1000.
https://www.nature.com/articles/s41467-022-33193-0
#IPF #Bioinformatics #SingleCell
Do give it a read :)
NatureAirway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis - Nature CommunicationsThe functional role of airway basal cells has not been comprehensively studied in idiopathic pulmonary fibrosis (IPF). Here, the authors show that airway basal cells of IPF patients display a distinct phenotype, are profibrotic if transplanted to mice and that fibrosis can be ameliorated by Src iinhibitors.