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New study results incoming!
Our new study discusses the importance of high-sensitivity cardiac troponin T (hs-cTnT) as a marker of myocardial injury in the diagnosis of cardiac disease. Currently recommended reference values are based on healthy populations, but there is evidence of differences in hs-cTnT levels according to age, sex, and race, especially in hospitalized patients without diagnosed cardiac disease.
More about this under the comments or here: https://doi.org/10.1515/cclm-2023-0040
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The study included two independent cohorts: a population-based cohort of 9 882 healthy subjects from the LIFE-Adult study in Leipzig, and a hospital-based cohort of 43 328 patients from Leipzig University Hospital. In both cohorts, subjects with suspected or diagnosed cardiac disease were excluded.
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Key findings:
- age and sex had a significant effect on the 99th percentile of serum hs-cTnT concentration in both cohorts
- hospitalization is associated with higher hs-cTnT levels in in most age groups than in individuals in the general population, even in patients without diagnosed or suspected heart disease
- age- and sex-specific hs-cTnT reference values may be beneficial for hospitalized patients
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